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MZB1-Driven Endoplasmic reticulum stress model as a predictor of breast cancer progression and survival.
Functional & integrative genomics
Aug 29, 2025
Endoplasmic reticulum (ER) stress and its associated unfolded protein response (UPR) have been demonstrated to play a crucial role in cancer's progression, but their prognostic significance in breast cancer (BC) remains unclear. In this study, a reli...
Deep learning in chromatin organization: from super-resolution microscopy to clinical applications.
Cellular and molecular life sciences : CMLS
Aug 29, 2025
The 3D organization of the genome plays a critical role in regulating gene expression, maintaining cellular identity, and mediating responses to environmental cues. Advances in super-resolution microscopy and genomic technologies have enabled unprece...
Thrifty wide-context models of B cell receptor somatic hypermutation.
eLife
Aug 29, 2025
Somatic hypermutation (SHM) is the diversity-generating process in antibody affinity maturation. Probabilistic models of SHM are needed for analyzing rare mutations, understanding the selective forces guiding affinity maturation, and understanding th...
Identifying key brain pathology in bipolar and unipolar depression using a region-specific brain aging trajectories approach: Insights from the Taiwan Aging and Mental Illness Cohort.
Psychological medicine
Aug 29, 2025
BACKGROUND: Identifying key areas of brain dysfunction in mental illness is critical for developing precision diagnosis and treatment. This study aimed to develop region-specific brain aging trajectory prediction models using multimodal magnetic reso...
A cross-sectional and bioinformatics-based analysis: perirenal fat thickness as a superior predictor of kidney stone disease.
Lipids in health and disease
Aug 29, 2025
BACKGROUND: Kidney stone disease (KSD) is a growing global health concern, with obesity (OB) as a major risk factor linked to metabolic dysfunction and chronic inflammation. Although the common method for evaluating OB is body mass index (BMI), it is...
Prediction-powered inference for clinical trials: application to linear covariate adjustment.
BMC medical research methodology
Aug 29, 2025
Prediction-powered inference (PPI) (Angelopoulos et al., Science 382(6671):669-674, 2023) and its subsequent development called PPI++ (Angelopoulos et al., 2023) provide a novel approach to standard statistical estimation, leveraging machine learning...
Review of GPU-based Monte Carlo simulation platforms for transmission and emission tomography in medicine.
Physics in medicine and biology
Aug 29, 2025
. Monte Carlo (MC) simulation remains the gold standard for modeling complex physical interactions in transmission and emission tomography, with graphic processing unit (GPU) parallel computing offering unmatched computational performance and enablin...
Recent progress and perspective of magnetic miniature soft robot with multimodal locomotion.
Bioinspiration & biomimetics
Aug 29, 2025
Multimodal miniature soft robots, with their higher movement flexibility and environmental adaptability, represent a crucial direction for the future development of soft robots. Magnetic-driven robots, owing to their advantages such as excellent remo...
SamRobNODDI:-space sampling-augmented continuous representation learning for robust and generalized NODDI.
Physics in medicine and biology
Aug 29, 2025
. Neurite orientation dispersion and density imaging (NODDI) microstructure estimation from diffusion magnetic resonance imaging (dMRI) is of great significance for the discovery and treatment of various neurological diseases. Current deep learning-b...
Ocotillo optimization-driven deep learning for bone marrow cytology classification.
PloS one
Aug 29, 2025
Manual diagnosis of hematological cancers like leukemia through bone marrow smear analysis is labor-intensive, prone to errors, and highly dependent on expert knowledge. To overcome these limitations, this study introduces a comprehensive deep learni...
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