YTHDC2, a unique YTH-domain-containing protein that recognizes N6-methyladenosine (mA) on RNA, plays critical roles in diverse pathological processes and represents a promising therapeutic target. Despite its potential, no potent small-molecule inhib...
BACKGROUND: Accurate classification and grading of lymphoma subtypes are essential for treatment planning. Traditional diagnostic methods face challenges of subjectivity and inefficiency, highlighting the need for automated solutions based on deep le...
BACKGROUND: In 2019, global sleep surveys reported that 80% of adults want to improve their sleep quality, and in 2021, 45% were reported to be dissatisfied with their sleep. In 2025, among American adults, 37% reported sleep dissatisfaction and 38% ...
BACKGROUND: Undiagnosed cognitive impairment poses a global challenge, prompting recent interest in ultra-brief screening questionnaires (comprising <2 to 3 items) to efficiently identify individuals needing further evaluation. However, evidence on u...
BACKGROUND: Artificial intelligence (AI) literacy is increasingly essential for medical students. However, without systematic characterization of the relevant components, designing targeted medical education interventions may be challenging.
The development of neoantigen-based cancer vaccines has emerged as a groundbreaking approach in the field of personalized oncology. Neoantigens, originating from tumor-specific somatic mutations, possess considerable immunogenic potential and are abs...
BACKGROUND: Keratoconus (KCN) is a progressive degenerative corneal disorder characterized by corneal thinning and cone-shaped protrusion, leading to significant visual impairment if not detected early. Accurate staging of KCN using corneal topograph...
BACKGROUND: Artificial intelligence (AI), particularly large language models (LLMs) such as ChatGPT (OpenAI), is rapidly influencing medical education. Its effectiveness for students with varying levels of prior knowledge remains underexplored.
Influenza viruses exhibit high mutation rates and extensive genetic diversity, which hinder effective vaccine development and facilitate immune evasion (Taubenberger and Morens, 2006; Barr et al., 2010). These mutations arise from the error-prone vir...
BACKGROUND: Despite the predictive impact of circulating tumor DNA (ctDNA) minimal residual disease (MRD), accurate prediction of failure risk after curative-intent treatments for early-stage or localized non-small cell lung cancer (NSCLC) patients t...
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