AIMC Topic: Humans

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Biomimetic magnetobacterial microrobots for active pneumonia therapy.

Nature communications
Immense progress in synthetic micro-/nanorobots with diverse functionalities has been made for biomedical applications during the last decade. However, there is still a huge gap for miniature robots to realize efficient therapy from in vitro to in vi...

Harnessing artificial intelligence to identify Bufalin as a molecular glue degrader of estrogen receptor alpha.

Nature communications
Target identification in natural products plays a critical role in the development of innovative drugs. Bufalin, a compound derived from traditional medicines, has shown promising anti-cancer activity; however, its precise molecular mechanism of acti...

Human iPSC-derived spinal neural progenitors enhance sensorimotor recovery in spinal cord-injured NOD-SCID mice via differentiation and microenvironment regulation.

Cell death & disease
Spinal cord injury (SCI) remains a significant clinical challenge and poses a dramatic threat to the life quality of patients due to limited neural regeneration and detrimental post-injury alternations in tissue microenvironment. We developed a thera...

Decoding target discriminability and time pressure using eye and head movement features in a foraging search task.

Cognitive research: principles and implications
In military operations, rapid and accurate decision-making is crucial, especially in visually complex and high-pressure environments. This study investigates how eye and head movement metrics can infer changes in search behavior during a naturalistic...

Constructing a predictive model for acute mastitis in lactating women based on machine learning.

Scientific reports
Acute lactational mastitis is a frequently occurring complication for lactating women, exerting a certain degree of influence on their physical condition, breastfeeding, mental health, and daily life. The etiology of this disease is complex, and the ...

Machine learning-optimized dual-band wearable antenna for real-time remote patient monitoring in biomedical IoT systems.

Scientific reports
This work presents a machine learning (ML)-optimized dual-band wearable antenna designed specifically for biomedical applications in healthcare monitoring. Fabricated on a Rogers substrate of 40 × 41 mm, the antenna operates at 2.4 GHz and 5.8 GHz wi...

Machine learning enhanced expert system for detecting heart failure decompensation using patient reported vitals and electronic health records.

Scientific reports
Heart failure (HF) is a condition with periods of stability interrupted by periods of worsening symptoms, known as decompensation episodes. Digital interventions are promising tools to alleviate burdens on HF management through automated alerts at th...

Altered brain structure age gap estimation in major depressive disorder patients with and without anhedonia: a machine learning-based study.

Translational psychiatry
Previous studies have found that major depressive disorder (MDD) may accelerate overall structural brain aging. Nevertheless, it still remains unknown whether anhedonia, a critical negative prognostic indicator in MDD, further leads to advanced brain...

Machine-learning approach to atrial fibrillation prediction among individuals without prior cardiovascular diseases.

Open heart
BACKGROUND: There is a lack of atrial fibrillation (AF) prediction models tailored for individuals without prior cardiovascular diseases (CVDs) to facilitate early intervention. This study aimed to develop and validate an AF prediction model using ma...

Development and validation of a predictive model for new HIV infection screening among persons 15 years and above in primary healthcare settings in Kenya: a study protocol.

BMJ health & care informatics
INTRODUCTION: This study seeks to determine incidence, comorbidities and drivers for new HIV infections to develop, test and validate a risk prediction model for screening for new cases of HIV.