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Network-Based Disease Module Discovery by a Novel Seed Connector Algorithm with Pathobiological Implications.

Journal of molecular biology
Understanding the genetic basis of complex diseases is challenging. Prior work shows that disease-related proteins do not typically function in isolation. Rather, they often interact with each other to form a network module that underlies dysfunction...

Analysis of hepatitis B virus infection in blood sera using Raman spectroscopy and machine learning.

Photodiagnosis and photodynamic therapy
This study presents the analysis of hepatitis B virus (HBV) infection in human blood serum using Raman spectroscopy combined with pattern recognition technique. In total, 119 confirmed samples of HBV infected sera, collected from Pakistan Atomic Ener...

High-Grade Serous Ovarian Cancer: Use of Machine Learning to Predict Abdominopelvic Recurrence on CT on the Basis of Serial Cancer Antigen 125 Levels.

Journal of the American College of Radiology : JACR
PURPOSE: The aim of this study was to use machine learning to predict abdominal recurrence on CT on the basis of serial cancer antigen 125 (CA125) levels in patients with advanced high-grade serous ovarian cancer on surveillance.

Fully automatic and robust segmentation of the clinical target volume for radiotherapy of breast cancer using big data and deep learning.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
PURPOSE: To train and evaluate a very deep dilated residual network (DD-ResNet) for fast and consistent auto-segmentation of the clinical target volume (CTV) for breast cancer (BC) radiotherapy with big data.

Factors associated with dementia in elderly.

Ciencia & saude coletiva
We analyzed the factors associated with dementia in the elderly attended at a memory outpatient clinic of the University of Southern Santa Catarina (UNISUL). This is a cross-sectional study with data analysis of medical records from January 2013 to A...

Classifying medical relations in clinical text via convolutional neural networks.

Artificial intelligence in medicine
Deep learning research on relation classification has achieved solid performance in the general domain. This study proposes a convolutional neural network (CNN) architecture with a multi-pooling operation for medical relation classification on clinic...

Optimal two-stage dynamic treatment regimes from a classification perspective with censored survival data.

Biometrics
Clinicians often make multiple treatment decisions at key points over the course of a patient's disease. A dynamic treatment regime is a sequence of decision rules, each mapping a patient's observed history to the set of available, feasible treatment...
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Phrase mining of textual data to analyze extracellular matrix protein patterns across cardiovascular disease.

American journal of physiology. Heart and circulatory physiology
Extracellular matrix (ECM) proteins have been shown to play important roles regulating multiple biological processes in an array of organ systems, including the cardiovascular system. Using a novel bioinformatics text-mining tool, we studied six cate...
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Mapping Cellular Polarity Networks Using Mass Spectrometry-based Strategies.

Journal of molecular biology
Cell polarity is a vital biological process involved in the building, maintenance and normal functioning of tissues in invertebrates and vertebrates. Unsurprisingly, molecular defects affecting polarity organization and functions have a strong impact...