Humans
Showing 70101 to 70110 of 95995 articles
Genomic risk prediction of aromatase inhibitor-related arthralgia in patients with breast cancer using a novel machine-learning algorithm.
Cancer medicine
Nov 23, 2017
Many breast cancer (BC) patients treated with aromatase inhibitors (AIs) develop aromatase inhibitor-related arthralgia (AIA). Candidate gene studies to identify AIA risk are limited in scope. We evaluated the potential of a novel analytic algorithm ...
The Wisdom of Networks: A General Adaptation and Learning Mechanism of Complex Systems: The Network Core Triggers Fast Responses to Known Stimuli; Innovations Require the Slow Network Periphery and Are Encoded by Core-Remodeling.
BioEssays : news and reviews in molecular, cellular and developmental biology
Nov 23, 2017
I hypothesize that re-occurring prior experience of complex systems mobilizes a fast response, whose attractor is encoded by their strongly connected network core. In contrast, responses to novel stimuli are often slow and require the weakly connecte...
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Deep Convolutional Neural Network-Based Early Automated Detection of Diabetic Retinopathy Using Fundus Image.
Molecules (Basel, Switzerland)
Nov 23, 2017
The automatic detection of diabetic retinopathy is of vital importance, as it is the main cause of irreversible vision loss in the working-age population in the developed world. The early detection of diabetic retinopathy occurrence can be very helpf...
Meta-Path Methods for Prioritizing Candidate Disease miRNAs.
IEEE/ACM transactions on computational biology and bioinformatics
Nov 22, 2017
MicroRNAs (miRNAs) play critical roles in regulating gene expression at post-transcriptional levels. Numerous experimental studies indicate that alterations and dysregulations in miRNAs are associated with important complex diseases, especially cance...
Cross Euclidean-to-Riemannian Metric Learning with Application to Face Recognition from Video.
IEEE transactions on pattern analysis and machine intelligence
Nov 22, 2017
Riemannian manifolds have been widely employed for video representations in visual classification tasks including video-based face recognition. The success mainly derives from learning a discriminant Riemannian metric which encodes the non-linear geo...
Deep Learning in Microscopy Image Analysis: A Survey.
IEEE transactions on neural networks and learning systems
Nov 22, 2017
Computerized microscopy image analysis plays an important role in computer aided diagnosis and prognosis. Machine learning techniques have powered many aspects of medical investigation and clinical practice. Recently, deep learning is emerging as a l...
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Selective cytotoxic and genotoxic activities of 5-(2-bromo-5-methoxybenzylidene)-thiazolidine-2,4-dione against NCI-H292 human lung carcinoma cells.
Pharmacological reports : PR
Nov 22, 2017
BACKGROUND: Thiazolidine-2,4-dione ring system is used as a pharmacophore to build various heterocyclic compounds aimed to interact with biological targets. In the present study, benzylidene-2,4-thiazolidinedione derivatives (compounds 2-5) were synt...
Looking for Alzheimer's Disease morphometric signatures using machine learning techniques.
Journal of neuroscience methods
Nov 22, 2017
BACKGROUND: We present our results in the International challenge for automated prediction of MCI from MRI data. We evaluate the performance of MRI-based neuromorphometrics features (nMF) in the classification of Healthy Controls (HC), Mild Cognitive...
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Bladder contractility index in posterior urethral valve: A new marker for early prediction of progression to renal failure.
Journal of pediatric urology
Nov 22, 2017
INTRODUCTION: Posterior urethral valve (PUV) is the most common cause of pediatric end stage renal disease (ESRD), imposing a major health burden on medical community caregivers and adversely affecting the quality of life of patients. Chronic kidney ...
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Risk Assessment
Disease Progression
Cohort Studies
Time Factors
Child, Preschool
Child
ROC Curve
India
Biomarkers
Retrospective Studies
Female
Male
Humans
Urinary Bladder Neck Obstruction
Databases, Factual
Proportional Hazards Models
Urodynamics
Muscle Contraction
Renal Insufficiency, Chronic
Vesico-Ureteral Reflux
Urethral Stricture
Follow-Up Studies
Urinary Bladder
Predictive Value of Tests
Kidney Failure, Chronic
Integrating DNA structure switch with branched hairpins for the detection of uracil-DNA glycosylase activity and inhibitor screening.
Talanta
Nov 22, 2017
The detection of uracil-DNA glycosylase (UDG) activity is pivotal for its biochemical studies and the development of drugs for UDG-related diseases. Here, we explored an integrated DNA structure switch for high sensitive detection of UDG activity. Th...
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