AIMC Topic: Lipopolysaccharides
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Automating the Illumina DNA library preparation kit for whole genome sequencing applications on the flowbot ONE liquid handler robot.
Scientific reports
Apr 8, 2024
Whole-genome sequencing (WGS) is currently making its transition from research tool into routine (clinical) diagnostic practice. The workflow for WGS includes the highly labor-intensive library preparations (LP), one of the most critical steps in the...
Machine learning and genetic algorithm-guided directed evolution for the development of antimicrobial peptides.
Journal of advanced research
Mar 1, 2024
INTRODUCTION: Antimicrobial peptides (AMPs) are valuable alternatives to traditional antibiotics, possess a variety of potent biological activities and exhibit immunomodulatory effects that alleviate difficult-to-treat infections. Clarifying the stru...
Pepsin Hydrolysate from Surimi Industry-Related Olive Flounder Head Byproducts Attenuates LPS-Induced Inflammation and Oxidative Stress in RAW 264.7 Macrophages and In Vivo Zebrafish Model.
Marine drugs
Dec 28, 2023
Fish head byproducts derived from surimi processing contribute about 15% of the total body weight, which are beneficial to health because they contain essential nutrients. In this study, olive flounder (OF) was the target species in order to maximize...
Anti-inflammatory and antioxidative actions of tacrolimus (FK506) on human microglial HMC3 cell line.
Scandinavian journal of immunology
Nov 13, 2023
Microglial cells are indispensable for the normal development and functioning of neurons in the central nervous system, where they play a crucial role in maintaining brain homeostasis by surveilling the microenvironment for signs of injury or stress ...
High-Content Image-Based Screening and Deep Learning for the Detection of Anti-Inflammatory Drug Leads.
Chembiochem : a European journal of chemical biology
Nov 7, 2023
We developed a high-content image-based screen that utilizes the pro-inflammatory stimulus lipopolysaccharide (LPS) and murine macrophages (RAW264.7) with the goal of enabling the identification of novel anti-inflammatory lead compounds. We screened ...
PINK1 dominated mitochondria associated genes signature predicts abdominal aortic aneurysm with metabolic syndrome.
Biochimica et biophysica acta. Molecular basis of disease
Oct 30, 2023
Abdominal aortic aneurysm (AAA) is typically asymptomatic but a devastating cardiovascular disorder, with overall mortality exceeding 80 % once it ruptures. Some patients with AAA may also have comorbid metabolic syndrome (MS), suggesting a potential...
E. globulus leaf EO exhibits anti-inflammatory effects by regulating GSDMD-mediated pyroptosis, thereby alleviating neurological impairment and neuroinflammation in experimental stroke mice.
Journal of ethnopharmacology
Oct 30, 2023
ETHNOPHARMACOLOGICAL RELEVANCE: Aromatic and medicinal plants continue to be a major component of alternative and traditional medicine in the developing countries. Eucalyptus globulus (Labill.) is being employed to cultivation and production in China...
Plant Leaves
Anti-Infective Agents
Tumor Necrosis Factor-alpha
Neuroinflammatory Diseases
Inflammation
NLR Family, Pyrin Domain-Containing 3 Protein
Stroke
Microglia
Pyroptosis
NF-kappa B
Rats, Sprague-Dawley
Interleukin-6
Animals
Infarction, Middle Cerebral Artery
Anti-Inflammatory Agents
Lipopolysaccharides
Mice
DNA-Binding Proteins
Rats
The water-soluble subfraction from Artemisia argyi alleviates LPS-induced inflammatory responses via multiple pathways and targets in vitro and in vivo.
Journal of ethnopharmacology
Oct 28, 2023
ETHNOPHARMACOLOGICAL RELEVANCE: As a traditional Chinese medicine, Artemisia argyi has been used medicinally and eaten for more than 2000 years in China. It is widely reported in treating inflammatory diseases such as eczema, dermatitis, arthritis, a...
Physicochemical Profiling of Macrophage Heterogeneity Using Deep Learning Integrated Nanosensor Cytometry.
ACS sensors
Apr 5, 2023
Label-free single-cell analytics have been developed for understanding the collective immune response mechanism of immune cells. However, it remains difficult to analyze the physicochemical properties of a single cell in high spatiotemporal resolutio...
Single Cell RNA-Seq and Machine Learning Reveal Novel Subpopulations in Low-Grade Inflammatory Monocytes With Unique Regulatory Circuits.
Frontiers in immunology
Feb 23, 2021
Subclinical doses of LPS (SD-LPS) are known to cause low-grade inflammatory activation of monocytes, which could lead to inflammatory diseases including atherosclerosis and metabolic syndrome. Sodium 4-phenylbutyrate is a potential therapeutic compou...
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