BACKGROUND: Combination immunotherapies, such as pembrolizumab plus lenvatinib (PL), are commonly used in treatment for unresectable hepatocellular carcinoma (uHCC). However, it remains challenging to predict which patients will benefit from this the...
Deep learning models are prone to failure when inferring upon out-of-distribution (OOD) data, i.e. data whose features fundamentally differ from those in the training set. Existing OOD measures often lack sensitivity to the subtle image variations en...
Hepatocellular carcinoma (HCC) is a biologically and clinically heterogeneous malignancy, whose initiation and progression are increasingly recognized to be driven by the aberrant regulation of programmed cell death (PCD) pathways. To elucidate this ...
OBJECTIVE: Microvascular invasion (MVI) is of great significance for the individualized treatment of hepatocellular carcinoma (HCC) and preoperative noninvasive prediction of MVI is still an urgent clinical problem. To explore the effects of differen...
BACKGROUND: Early diagnosis of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) is challenging. Models that combine novel biomarkers with clinical features may improve both early diagnosis and risk stratification, but f...
Colon cancer is one of the leading causes of cancer-related mortality, with liver metastasis commonly complicating its progression and significantly worsening patient prognosis. This study aims to explore the relationship between liver metastasis in ...
XGBoost, a gradient boosting algorithm, is widely recognized for its efficiency and robustness in multiclass classification tasks. Metabolomics serves as a powerful tool for biomarker discovery; however, metabolic biomarkers associated with the progr...
Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC), yet resistance limits its efficacy. The Hedgehog (HH) signaling pathway contributes to drug resistance by maintaining HCC stem cell characteristics, but its role at the ...
OBJECTIVE: Posthepatectomy recurrence of hepatocellular carcinoma (HCC) is a major cause of poor prognosis. Accurate prediction is essential for reducing the burden of advanced disease and improving outcomes.
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