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Liver Neoplasms

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Deep Learning-Based Auto-Segmentation for Liver Yttrium-90 Selective Internal Radiation Therapy.

Technology in cancer research & treatment
The aim was to evaluate a deep learning-based auto-segmentation method for liver delineation in Y-90 selective internal radiation therapy (SIRT). A deep learning (DL)-based liver segmentation model using the U-Net3D architecture was built. Auto-segme...

Untargeted Lipidomic Biomarkers for Liver Cancer Diagnosis: A Tree-Based Machine Learning Model Enhanced by Explainable Artificial Intelligence.

Medicina (Kaunas, Lithuania)
: Liver cancer ranks among the leading causes of cancer-related mortality, necessitating the development of novel diagnostic methods. Deregulated lipid metabolism, a hallmark of hepatocarcinogenesis, offers compelling prospects for biomarker identifi...

Gd-EOB-DTPA-enhanced MRI radiomics and deep learning models to predict microvascular invasion in hepatocellular carcinoma: a multicenter study.

BMC medical imaging
BACKGROUND: Microvascular invasion (MVI) is an important risk factor for early postoperative recurrence of hepatocellular carcinoma (HCC). Based on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance ...

Predicting hepatocellular carcinoma response to TACE: A machine learning study based on 2.5D CT imaging and deep features analysis.

European journal of radiology
OBJECTIVES: Prior to the commencement of treatment, it is essential to establish an objective method for accurately predicting the prognosis of patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE). In this st...

ResTransUNet: A hybrid CNN-transformer approach for liver and tumor segmentation in CT images.

Computers in biology and medicine
BACKGROUND AND OBJECTIVE: Accurate medical tumor segmentation is critical for early diagnosis and treatment planning, significantly improving patient outcomes. This study aims to enhance liver and tumor segmentation from CT and liver images by develo...

Identification of CACNB1 protein as an actionable therapeutic target for hepatocellular carcinoma via metabolic dysfunction analysis in liver diseases: An integrated bioinformatics and machine learning approach for precise therapy.

International journal of biological macromolecules
In addition to histological evaluation for nonalcoholic fatty liver disease (NAFLD), a comprehensive analysis of the metabolic landscape is urgently needed to categorize patients into distinct subgroups for precise treatment. In this study, a total o...

Deep learning-based reconstruction and superresolution for MR-guided thermal ablation of malignant liver lesions.

Cancer imaging : the official publication of the International Cancer Imaging Society
OBJECTIVE: This study evaluates the impact of deep learning-enhanced T1-weighted VIBE sequences (DL-VIBE) on image quality and procedural parameters during MR-guided thermoablation of liver malignancies, compared to standard VIBE (SD-VIBE).

Evaluating the dosimetric and positioning accuracy of a deep learning based synthetic-CT model for liver radiotherapy treatment planning.

Biomedical physics & engineering express
An MRI-only workflow requires synthetic computed tomography (sCT) images to enable dose calculation. This study evaluated the dosimetric and patient positioning accuracy of deep learning-generated sCT for liver radiotherapy.sCT images were generated ...

Integrating single-cell RNA sequencing, WGCNA, and machine learning to identify key biomarkers in hepatocellular carcinoma.

Scientific reports
The microarray and single-cell RNA-sequencing (scRNA-seq) datasets of hepatocellular carcinoma (HCC) were downloaded from the Gene Expression Omnibus (GEO) database. Differential expression analysis and weighted gene co-expression network analysis (W...

Deep Learning-Accelerated Non-Contrast Abbreviated Liver MRI for Detecting Malignant Focal Hepatic Lesions: Dual-Center Validation.

Korean journal of radiology
OBJECTIVE: To compare a deep learning (DL)-accelerated non-enhanced abbreviated MRI (AMRI) protocol with standard AMRI (AMRI) of the liver in terms of image quality and malignant focal lesion detection.