Journal of pharmacokinetics and pharmacodynamics
Jun 16, 2025
Quantitative Systems Pharmacology (QSP) has emerged as a cornerstone of modern drug development, providing a robust framework to integrate data from preclinical and clinical studies, enhance decision-making, and optimize therapeutic strategies. By mo...
BACKGROUND: In the context of escalating global mental health challenges, adolescent suicide has become a critical public health concern. In current clinical practices, considerable challenges are encountered in the early identification of suicide ri...
The revisit of the emergency department (ED) is a key indicator of emergency care quality. Various strategies have been proposed to reduce ED revisits, including the use of artificial intelligence (AI) models for prediction. However, AI model perform...
Split G-quadruplexes are considered excellent tools for biosensing and diagnostics, but splitting G-quadruplexes may often lead to a loss of function, limiting their effectiveness. This study aims to identify and classify functional split G-quadruple...
The Journal of clinical investigation
Jun 16, 2025
As antimicrobial resistance rises, new antibacterial candidates are urgently needed. Using sequence space information from over 14,743 functional antimicrobial peptides (AMPs), we improved the antimicrobial properties of citropin 1.1, an AMP with wea...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Jun 15, 2025
Tumor-associated macrophages (TAMs) are a vital immune component within the tumor microenvironment (TME) of lung adenocarcinoma (LUAD), exerting significant influence on tumor growth, metastasis, and drug resistance. N6-methyladenosine (m6A) modifica...
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Jun 15, 2025
To address the identification challenges caused by morphological similarities in Root and Rhizome Chinese Herbal (RRCH), this study developed a discrimination system integrating Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (AT...
Environmental pollution (Barking, Essex : 1987)
Jun 15, 2025
Microplastics (MPs) have emerged as a pervasive environmental pollutant due to their persistence and global distribution. However, MPs relationships with covariables remain largely unexplored. This study investigates factors influencing MPs occurrenc...
Clinica chimica acta; international journal of clinical chemistry
Jun 15, 2025
OBJECTIVES: The World Health Organization has identified Klebsiella pneumoniae (KP) and Pseudomonas aeruginosa (PA) as significant public health threats owing to high antibiotic resistance. Traditional antibiotic susceptibility testing (AST) methods,...
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