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The Clinical Prognostic Value of Lactylation-Regulated Proteins in Gastric Cancer.

Journal of proteome research
Gastric cancer (GC) is a leading cause of cancer-related mortality globally. Histone lactylation, an emerging post-translational modification, holds promise as a therapeutic target and prognostic biomarker, though its expression patterns and clinical...

Circulating long non-coding RNAs as predictors of type 2 diabetes mellitus development: results from the CORDIOPREV study.

Cardiovascular diabetology
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a growing global health challenge. Conventional diagnostic tools have limited sensitivity and specificity for early-stage disease. In this context, long non-coding RNAs (lncRNAs) have emerged as promisin...

Construction and validation of the prediction model for kinesiophobia in older adults with chronic low back pain.

BMC geriatrics
BACKGROUND: Low back pain imposes a substantial burden on global healthcare systems. Kinesiophobia is highly prevalent among older adults with chronic low back pain, severely hindering effective intervention and treatment. However, current assessment...

Precise diagnosis of small invasive pulmonary nodules driven by single-cell immune signatures in peripheral blood.

Nature communications
Early detection of lung cancer is crucial for improving patient outcomes. However, accurately diagnosing invasive pulmonary nodules and predicting tumor invasiveness remain major clinical challenges. Given the established role of immune dysfunction i...

COVID-19 severity analysis for clinical decision support based on machine learning approach.

Scientific reports
The COVID-19 pandemic has placed immense pressure on global healthcare systems, underscoring the urgent need for early and accurate prediction of disease severity to improve patient care and optimize resource allocation. Failure in ward allocation ca...

Exploring Perspectives of Health Care Professionals on AI in Palliative Care: Qualitative Interview Study.

JMIR human factors
BACKGROUND: The use of artificial intelligence (AI) methods in palliative care research is increasing. Most AI palliative care research involves the use of routinely collected data from electronic health records; however, there are few data on the vi...

Understanding Physician Attitudes Toward AI in Clinical Decision-Making: Cross-Sectional Study.

JMIR formative research
BACKGROUND: The Kingdom of Saudi Arabia (KSA) has made tremendous efforts to promote the adoption of advanced technologies such as artificial intelligence (AI). While the successful adoption of AI is dependent on physician perception, there is a scar...

Bridging the AI-Literacy Gap in Health Care: Qualitative Analysis of the Flanders Case Study.

Journal of medical Internet research
BACKGROUND: Building on the assertion that nearly every clinician will eventually use artificial intelligence (AI), this study provides a triangulated qualitative analysis of the requirements, challenges, and prospects for integrating AI into routine...

Automatic detection of urinary stones from non-contrast enhanced computed tomography images.

Urolithiasis
Urinary stones, one of the most common emergency conditions, traverse the ureter, urine flow is obstructed, resulting in hydronephrosis and severe pain. However, vessel wall calcifications or phleboliths are frequently observed in abdominal and pelvi...

Machine learning model of clinical laboratory data for 30-day mortality of patients with hodgkin's lymphoma in ICU: a retrospective study based on MIMIC-IV database.

Clinical and experimental medicine
Prognostic stratification of Hodgkin lymphoma (HL) patients in ICU remains challenging, with conventional scoring systems often overlooking pathophysiological biomarkers. This retrospective cohort study analyzed 1,908 HL patients from the MIMIC-IV da...