AIMC Topic: MAP Kinase Signaling System

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A Novel Morphological Marker for the Analysis of Molecular Activities at the Single-cell Level.

Cell structure and function Jun 29, 2018
For more than a century, hematoxylin and eosin (H&E) staining has been the de facto standard for histological studies. Consequently, the legacy of histological knowledge is largely based on H&E staining. Due to the recent advent of multi-photon excit...
Machine Learning Animals Single-Cell Analysis Imaging, Three-Dimensional Madin Darby Canine Kidney Cells Fluorescence Resonance Energy Transfer MAP Kinase Signaling System Mice, Transgenic Biosensing Techniques Mice, Inbred C57BL Microscopy, Fluorescence Dogs
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Leptin Stimulates Prolactin mRNA Expression in the Goldfish Pituitary through a Combination of the PI3K/Akt/mTOR, MKK/pMAPK and MEK/ERK Signalling Pathways.

International journal of molecular sciences Dec 20, 2017
Leptin actions at the pituitary level have been extensively investigated in mammalian species, but remain insufficiently characterized in lower vertebrates, especially in teleost fish. Prolactin (PRL) is a pituitary hormone of central importance to o...
Prolactin Fish Proteins Goldfish Pituitary Gland Cells, Cultured Receptors, Leptin Proto-Oncogene Proteins c-akt Animals TOR Serine-Threonine Kinases RNA, Messenger Leptin Phosphatidylinositol 3-Kinases MAP Kinase Signaling System
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Basic fibroblast growth factor is critical to reprogramming buffalo (Bubalus bubalis) primordial germ cells into embryonic germ stem cell-like cells.

Theriogenology Dec 29, 2016
Primordial germ cells (PGCs) are destined to form gametes in vivo, and they can be reprogrammed into pluripotent embryonic germ (EG) cells in vitro. Buffalo PGC have been reported to be reprogrammed into EG-like cells, but the identities of the major...
Embryonic Germ Cells Pluripotent Stem Cells Signal Transduction Buffaloes Animals Cellular Reprogramming MAP Kinase Signaling System Cell Differentiation Cell Culture Techniques Fibroblast Growth Factors Cell Lineage
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Neuroprotective effects of the Phellinus linteus ethyl acetate extract against H2O2-induced apoptotic cell death of SK-N-MC cells.

Nutrition research (New York, N.Y.) Nov 11, 2015
Numerous studies have suggested that neuronal cells are protected against oxidative stress-induced cell damage by antioxidants, such as polyphenolic compounds. Phellinus linteus (PL) has traditionally been used to treat various symptoms in East Asian...
Basidiomycota Fruiting Bodies, Fungal Gene Expression Regulation, Enzymologic Oxidoreductases Polysaccharides Neurons Solvents MAP Kinase Signaling System Ethnopharmacology Medicine, Korean Traditional Phellinus Antioxidants Plant Extracts Neuroprotective Agents Apoptosis Biological Products Polyphenols Nerve Tissue Proteins Acetates Brain Republic of Korea Cell Line, Tumor Oxidative Stress Humans
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aqueous extract attenuates isoproterenol-induced cardiac hypertrophy through the ERK signalling pathway.

Pharmaceutical biology Dec 1, 2020
CONTEXT: The pharmacological functions of Wall. ex Lindl. (Orchidaceae) in cardiac hypertrophy remains unclear.
Myoblasts Plant Extracts Cell Line Fibrosis Rats Myocardium Myocytes, Cardiac Dendrobium Female Signal Transduction Heart Isoproterenol Animals Rats, Sprague-Dawley Cardiomegaly MAP Kinase Signaling System Male
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Machine-Learning Prediction of Drug-Induced Cardiac Arrhythmia: Analysis of Gene Expression and Clustering.

Critical reviews in biomedical engineering Jan 1, 2018
A marked delay in the electrical repolarization of heart ventricles is characterized by prolongation of the Q-T wave (QT) interval on a surface electrocardiogram. Such a delay can lead to potentially life-threatening cardiac arrhythmia (torsades de p...
Machine Learning Female Reproducibility of Results Sensitivity and Specificity Humans Gene Expression Regulation Clinical Trials as Topic False Positive Reactions Torsades de Pointes Gene Expression Profiling Support Vector Machine Mice Cluster Analysis Rats Signal Processing, Computer-Assisted Electrocardiography Drug Evaluation, Preclinical Heart Animals Heart Ventricles Male Arrhythmias, Cardiac Drug Design MAP Kinase Signaling System
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[Interleukin?22 promotes proliferation of fibroblast?like synoviocytes from patients with rheumatoid arthritis by inducing STAT3 phosphorylation].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University Dec 20, 2017
OBJECTIVE: To clarify the mechanism by which interleukin?22 (IL?22) promotes the proliferation of fibroblast?like synoviocytes (FLS) from patients with rheumatoid arthritis (RA).
Arthritis, Rheumatoid Synoviocytes Humans Interleukins Cell Proliferation Tyrphostins Cells, Cultured Phosphorylation Interleukin-22 Synovial Membrane STAT3 Transcription Factor Fibroblasts MAP Kinase Signaling System
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[Sodium Ferulate Attenuates Oxidative Stressvia Suppressing NALP3 Inflammasome and ERK Signal Pathway].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Sep 1, 2016
OBJECTIVES: Study the gene and protein expression of NACHT-PYD-containing protein 3 (NALP3) inflammasome and extracellular regulated protein kinase (ERK), the intervention effects of sodium ferulate (SF) in human lung epithelial cells A549 under oxid...
Humans Hydrogen Peroxide Oxidative Stress Inflammasomes Flavonoids MAP Kinase Signaling System A549 Cells Coumaric Acids Interleukin-1beta NLR Family, Pyrin Domain-Containing 3 Protein
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