Phytomedicine : international journal of phytotherapy and phytopharmacology
Oct 24, 2025
BACKGROUND: As global health challenges continue to evolve, herbal medicines (HMs) have garnered significant scientific interest as a valuable resource for treating complex diseases. However, the chemical complexity of HMs presents considerable chall...
Environmental challenges such as drought, salinity, heavy metal contamination, and nutrient deficiencies threaten global agricultural productivity and food security. These stressors drastically reduce crop yields, necessitating innovative solutions. ...
Metabolomics : Official journal of the Metabolomic Society
Oct 18, 2025
INTRODUCTION: The identification of unknown metabolites remains a major challenge in untargeted metabolomics using liquid chromatography-mass spectrometry (LC-MS). This process typically depends on comparing mass spectral or chromatographic data to r...
This tutorial offers a step-by-step guide for analytical chemists to train machine learning models for MS-based metabolomics. It covers data preparation, feature engineering, model selection, evaluation, and interpretation, along with real-world exam...
Dual-omics, by integrating molecular information from two distinct dimensions, can offer more comprehensive perspective for complex disease. Herein, we developed an efficient functionalized mesoporous nanoparticle-coupled laser desorption/ionization ...
XGBoost, a gradient boosting algorithm, is widely recognized for its efficiency and robustness in multiclass classification tasks. Metabolomics serves as a powerful tool for biomarker discovery; however, metabolic biomarkers associated with the progr...
This study focused on the regional differentiation of metabolites of C. bursa-pastoris cultivated across Korea via UHPLC‒HRMS‒based untargeted metabolomics. Extensive screening was conducted on samples collected from five distinct sites in 20 cities,...
Signal transduction and targeted therapy
Oct 13, 2025
Nearly 30% of patients with schizophrenia respond inadequately to current antipsychotics, with unclear markers and mechanisms of antipsychotic efficacy. A total of 208 patients with schizophrenia treated for 6 weeks with oral paliperidone were analyz...
Aldehyde compounds are significantly associated with diabetes mellitus. The metabolic profile of aldehydes can enhance understanding of the mechanisms underlying development of diabetes. This study employed a pair of stable isotope labeling (SIL) rea...
Atherosclerotic plaques are complex and heterogeneous structures, originating as fatty streaks in the vasculature and formed by the accumulation of lipids and foam cells. Over time, these lesions progress as inflammation, smooth muscle cell prolifera...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.