AIMC Topic: Mice, Inbred BALB C

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HPLC-UV method for simultaneous determination of MK-1775 and AZD-7762 in both acetonitrile-aqueous solution and mouse plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Dec 30, 2016
A sensitive and precise method is described for the simultaneous determination of two small molecule kinase inhibitors: MK-1775 (MK) and AZD-7762 (AZD), in acetonitrile (ACN)-aqueous solution and in mouse plasma. A Nova-Pak C18 reversed phase column ...
Pyrimidines Pyrimidinones Linear Models Pyrazoles Thiophenes Urea Spectrophotometry, Ultraviolet Mice Mice, Inbred BALB C Limit of Detection Chromatography, High Pressure Liquid Solid Phase Extraction Female Reproducibility of Results Animals
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Tenascin-C Prevents Articular Cartilage Degeneration in Murine Osteoarthritis Models.

Cartilage Dec 4, 2016
Objective The objective of this study was to determine whether intra-articular injections of tenascin-C (TNC) could prevent cartilage damage in murine models of osteoarthritis (OA). Design Fluorescently labeled TNC was injected into knee joints and i...
Knee Joint Injections, Intra-Articular Osteoarthritis, Knee Collagen Type II Cartilage, Articular Cartilage Diseases Male Animals Tenascin Mice Synovial Membrane Disease Models, Animal Mice, Inbred BALB C
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Vocal Fold Augmentation with Beta Glucan Hydrogel Cross-Linked by γ Irradiation for Enhanced Duration of Effect: In Vivo Animal Study.

BioMed research international Dec 13, 2015
This study explored a novel strategy to restore the vocal gap by using cross-linked β-glucan hydrogel by γ-irradiation. An aqueous solution of 5 wt% β-glucan was prepared and cross-linked using (60)Co γ irradiation. Ten nude mice were injected with 0...
Gamma Rays Mice, Inbred BALB C Animals Vocal Cord Paralysis beta-Glucans Mice Vocal Cords Rabbits Mice, Nude Materials Testing Hydrogels
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The antiviral activity of arctigenin in traditional Chinese medicine on porcine circovirus type 2.

Research in veterinary science Oct 26, 2015
Arctigenin (ACT) is a phenylpropanoid dibenzylbutyrolactone lignan extracted from the traditional herb Arctium lappa L. (Compositae) with anti-viral and anti-inflammatory effects. Here, we investigated the antiviral activity of ACT found in tradition...
Swine Diseases Antiviral Agents Mice Medicine, Chinese Traditional Mice, Inbred BALB C Injections, Intraperitoneal Furans Random Allocation Lignans Arctium Female Animals Swine Circoviridae Infections Circovirus
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Automated measurement of mouse social behaviors using depth sensing, video tracking, and machine learning.

Proceedings of the National Academy of Sciences of the United States of America Sep 9, 2015
A lack of automated, quantitative, and accurate assessment of social behaviors in mammalian animal models has limited progress toward understanding mechanisms underlying social interactions and their disorders such as autism. Here we present a new in...
Models, Animal Behavior, Animal Social Behavior Mice, Inbred BALB C Mice, Inbred C57BL Video Recording Observer Variation Pattern Recognition, Automated Machine Learning Software Algorithms Computers Female Reproducibility of Results Animals Male Image Processing, Computer-Assisted Mice
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Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery.

PLoS neglected tropical diseases Jun 26, 2015
BACKGROUND: Chagas disease is a neglected tropical disease (NTD) caused by the eukaryotic parasite Trypanosoma cruzi. The current clinical and preclinical pipeline for T. cruzi is extremely sparse and lacks drug target diversity.
Bayes Theorem High-Throughput Screening Assays Trypanosoma cruzi Disease Models, Animal Chagas Disease Mice, Inbred BALB C Trypanocidal Agents Cell Line Metabolic Networks and Pathways Genome, Protozoan Humans Female Machine Learning Animals Drug Discovery Mice Computational Biology
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Deep learning for in vivo near-infrared imaging.

Proceedings of the National Academy of Sciences of the United States of America Jan 5, 2021
Detecting fluorescence in the second near-infrared window (NIR-II) up to ∼1,700 nm has emerged as a novel in vivo imaging modality with high spatial and temporal resolution through millimeter tissue depths. Imaging in the NIR-IIb window (1,500-1,700 ...
Spectroscopy, Near-Infrared Deep Learning Cell Line, Tumor Mice Lymph Nodes Humans Neural Networks, Computer Animals Indocyanine Green Neoplasms Molecular Imaging Signal-To-Noise Ratio Intravital Microscopy Mice, Nude Cetuximab Mice, Inbred BALB C Fluorescent Dyes Microscopy, Fluorescence Indoles
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Anti-inflammatory and antibacterial activities of P. petiolosa (Christ) Ching ethyl acetate extract against S. aureus in mice.

Pakistan journal of pharmaceutical sciences Sep 1, 2020
P. petiolosa as a typical Chinese herbal medicine has been generally utilized as Chinese native medicine formulation for treatment of chronic bronchitis, bronchial asthma and pneumoconiosis. The objective of this study was to evaluate the anti-inflam...
Anti-Inflammatory Agents Acetates Membrane Proteins Solvents Anti-Bacterial Agents Inflammation Mediators Bacterial Load Staphylococcus aureus Nitric Oxide Synthase Type II Tumor Necrosis Factor-alpha Heme Oxygenase-1 Disease Models, Animal Animals Pneumonia, Staphylococcal Mice, Inbred BALB C Lung Polypodiaceae Plant Leaves Plant Extracts
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Machine Learning Uncovers Food- and Excipient-Drug Interactions.

Cell reports Mar 17, 2020
Inactive ingredients and generally recognized as safe compounds are regarded by the US Food and Drug Administration (FDA) as benign for human consumption within specified dose ranges, but a growing body of research has revealed that many inactive ing...
Retinyl Esters Pharmaceutical Preparations ATP Binding Cassette Transporter, Subfamily B, Member 1 Drug Interactions Biological Assay United States Food and Drug Administration Food Animals Diterpenes Humans Swine Glucuronosyltransferase Machine Learning United States Abietanes Female Hep G2 Cells Excipients Mice, Inbred BALB C
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A Deep Learning Approach to Antibiotic Discovery.

Cell Feb 20, 2020
Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting molecules with antibacterial activity. We performed pr...
Machine Learning Anti-Bacterial Agents Mycobacterium tuberculosis Acinetobacter baumannii Databases, Chemical Clostridioides difficile Small Molecule Libraries Animals Drug Discovery Mice Mice, Inbred BALB C Mice, Inbred C57BL Cheminformatics Thiadiazoles
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