AIMC Topic: Mice
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Fast, accurate, and versatile data analysis platform for the quantification of molecular spatiotemporal signals.
Cell
Apr 8, 2025
Optical recording of intricate molecular dynamics is becoming an indispensable technique for biological studies, accelerated by the development of new or improved biosensors and microscopy technology. This creates major computational challenges to ex...
Safety assessment of the ethanolic extract of Siparuna guianensis: Cell viability, molecular risk predictions and toxicity risk for acute and sub-chronic oral ingestion.
Journal of ethnopharmacology
Apr 5, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: The species Siparuna guianensis Aublet (family Siparunaceae) is traditionally used by indigenous peoples and riverine communities in Central and South America to treat migraines, flu, respiratory diseases, fever, pain,...
Comparative analysis of functional network dynamics in high and low alcohol preference mice.
Experimental neurology
Apr 4, 2025
Individual variability preference is a typical characteristic of alcohol drinking behaviors, with a higher risk for the development of alcohol use disorders (AUDs) in high alcohol preference (HP) populations. Here, we created a map of alcohol-related...
A Novel Theranostic Strategy for Malignant Pulmonary Nodules by Targeted CECAM6 with Zr/I-Labeled Tinurilimab.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Apr 3, 2025
Lung adenocarcinoma (LUAD) constitutes a major cause of cancer-related fatalities worldwide. Early identification of malignant pulmonary nodules constitutes the most effective approach to reducing the mortality of LUAD. Despite the wide application o...
Root of Prunus persica (taoshugen) ameliorated renal fibrosis by inhibiting TGF-β signaling via upregulating Pmepa1 in mice with unilateral ureter obstruction.
Journal of ethnopharmacology
Apr 3, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: Various parts of Prunus persica (L.) Batsch (peach) exhibit medicinal properties and are utilized in traditional Chinese medicine (TCM) for therapeutic purposes. Notably, the root of P. persica, referred to as "taoshug...
Therapeutic potential of allosteric HECT E3 ligase inhibition.
Cell
Apr 2, 2025
Targeting ubiquitin E3 ligases is therapeutically attractive; however, the absence of an active-site pocket impedes computational approaches for identifying inhibitors. In a large, unbiased biochemical screen, we discover inhibitors that bind a crypt...
Shengxuebao Mixture improves carboplatin-induced anemia by inhibiting apoptosis and ferroptosis.
Journal of ethnopharmacology
Apr 2, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: Shengxuebao Mixture (SXB) is a traditional Chinese medicine which has been widely used on treating Chemotherapy-induced leukopenia and multiple anemia. It remains unclear whether SXB has a role in chemotherapeutic-indu...
4-Hydroxyboesenbergin B of Alpinia japonica protected gastrointestinal tract by inhibiting vancomycin-resistant enterococcus and balancing intestinal microbiota.
Journal of ethnopharmacology
Apr 1, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: Alpinia japonica, a traditional herb utilized in Miao medicine in southwestern China, has been employed to alleviate symptoms such as stomachache, diarrhea, and abdominal pain, some of these symptoms may be associated ...
Enhancing cell instance segmentation in scanning electron microscopy images via a deep contour closing operator.
Computers in biology and medicine
Apr 1, 2025
Accurately segmenting and individualizing cells in scanning electron microscopy (SEM) images is a highly promising technique for elucidating tissue architecture in oncology. While current artificial intelligence (AI)-based methods are effective, erro...
Interpreting regulatory mechanisms of Hippo signaling through a deep learning sequence model.
Cell genomics
Apr 1, 2025
Signaling pathway components are well studied, but how they mediate cell-type-specific transcription responses is an unresolved problem. Using the Hippo pathway in mouse trophoblast stem cells as a model, we show that the DNA binding of signaling eff...
Muscle Proteins
Hippo Signaling Pathway
YAP-Signaling Proteins
TEA Domain Transcription Factors
Phosphoproteins
Trophoblasts
Enhancer Elements, Genetic
Protein Binding
Mice
Signal Transduction
Transcription Factors
Animals
Protein Serine-Threonine Kinases
Deep Learning
Adaptor Proteins, Signal Transducing
DNA-Binding Proteins
Molecular Dynamics Simulation
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