AIMC Topic: Mice

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The interplay between homeostatic synaptic scaling and homeostatic structural plasticity maintains the robust firing rate of neural networks.

eLife Jul 4, 2025
Critical network states and neural plasticity enable adaptive behavior in dynamic environments, supporting efficient information processing and experience-dependent learning. Synaptic-weight-based Hebbian plasticity and homeostatic synaptic scaling a...
Female Animals Male Mice Homeostasis Nerve Net Entorhinal Cortex Receptors, AMPA Neuronal Plasticity Neurons Synapses Hippocampus
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Machine learning-based integration identifies plasma cells-related gene signature ST6GAL1 in idiopathic pulmonary fibrosis.

BMC pulmonary medicine Jul 2, 2025
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a rare, progressive, and fibrotic disease with poor prognosis that lacks treatment options. As a major component of the lung adaptive immune system, plasma cells play a crucial regulatory role during...
Humans Mice Idiopathic Pulmonary Fibrosis Plasma Cells Sialyltransferases Machine Learning Prognosis Female Aged Animals Male Gene Expression Profiling Transcriptome
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Ensemble methods and partially-supervised learning for accurate and robust automatic murine organ segmentation.

Scientific reports Jul 2, 2025
Delineation of multiple organs in murine µCT images is crucial for preclinical studies but requires manual volumetric segmentation, a tedious and time-consuming process prone to inter-observer variability. Automatic deep learning-based segmentation c...
Image Processing, Computer-Assisted Mice Supervised Machine Learning X-Ray Microtomography Reproducibility of Results Animals Deep Learning Imaging, Three-Dimensional
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Integrating machine learning and bioinformatics approaches to identify novel diagnostic gene biomarkers for diabetic mice.

Scientific reports Jul 2, 2025
Diabetes is a complex metabolic disorder, and its pathogenesis involves the interplay of genetic, environmental factors, and lifestyle choices. With the rising prevalence and increasing associated chronic complications, identifying and understanding ...
Machine Learning Biomarkers Animals Gene Expression Profiling Gene Ontology Databases, Genetic HMGB1 Protein Diabetes Mellitus, Experimental Protein Interaction Maps Sirtuin 1 Gene Regulatory Networks Mice Computational Biology
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Lactylation associated biomarkers and immune infiltration in aortic dissection.

Scientific reports Jul 1, 2025
Protein lactylation, a novel post-translational modification (PTM), has emerged as a critical factor in disease processes related to glycolysis and immune responses. However, its role in aortic dissection (AD) has yet to be thoroughly investigated. T...
Gene Regulatory Networks Animals Aortic Dissection Humans Mice Phosphoglycerate Kinase Male Machine Learning Computational Biology Gene Expression Profiling Biomarkers Protein Processing, Post-Translational Transcriptome
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Machine learning-assisted decoding of temporal transcriptional dynamics via fluorescent timer.

Nature communications Jul 1, 2025
Investigating the temporal dynamics of gene expression is crucial for understanding gene regulation across various biological processes. Using the Fluorescent Timer protein, the Timer-of-cell-kinetics-and-activity system enables analysis of transcrip...
CRISPR-Cas Systems Flow Cytometry Forkhead Transcription Factors T-Lymphocytes, Regulatory Genes, Reporter Animals Gene Expression Regulation Neural Networks, Computer Single-Cell Analysis Spleen Machine Learning Mice Transcription, Genetic Mice, Inbred C57BL Enhancer Elements, Genetic
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Analysis of 2-dimensional regional differences in the peripapillary scleral fibroblast cytoskeleton of normotensive and hypertensive mouse eyes.

Scientific reports Jul 1, 2025
These studies aimed to study the mechanisms of glaucomatous peripapillary scleral (PPS) remodeling by investigating IOP-induced changes in fibroblast actin-collagen alignment and nuclear morphology in mouse PPS. Cryosections from the optic nerve head...
Actins Cytoskeleton Ocular Hypertension Sclera Glaucoma Mice, Inbred C57BL Male Intraocular Pressure Fibroblasts Mice Animals Collagen Disease Models, Animal Optic Disk
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Deep learning-driven drug response prediction and mechanistic insights in cancer genomics.

Scientific reports Jul 1, 2025
In the field of cancer therapy, the diversity and heterogeneity of cancer genomes in clinical patients complicate and challenge the effective use of non-targeted drugs, as these drugs often fail to address specific genetic events. Recent advancements...
Protein Kinase Inhibitors Adenine Apoptosis Xenograft Model Antitumor Assays Humans Genomics Piperidines Animals Gene Expression Regulation, Neoplastic Antineoplastic Agents Drug Resistance, Neoplasm Neoplasms Cell Proliferation Deep Learning Cell Line, Tumor Mice
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Deep-learning-based automated prediction of mouse seminiferous tubule stage by using bright-field microscopy.

Scientific reports Jul 1, 2025
Infertility is a global issue, and approximately 50% of cases are due to male factors, with defective spermatogenesis being the main one. For studies of spermatogenesis, evaluating the seminiferous tubule stage is essential. However, current evaluati...
Microscopy Spermatogenesis Seminiferous Tubules Reproducibility of Results Animals Male Deep Learning Image Processing, Computer-Assisted Mice
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Spatial patterns of hepatocyte glucose flux revealed by stable isotope tracing and multi-scale microscopy.

Nature communications Jul 1, 2025
Metabolic homeostasis requires engagement of catabolic and anabolic pathways consuming nutrients that generate and consume energy and biomass. Our current understanding of cell homeostasis and metabolism, including how cells utilize nutrients, comes ...
Animals Male Mice Glucose Humans Carbon Isotopes Lipid Droplets Endoplasmic Reticulum Mitochondria Hepatocytes Microscopy Glycogen
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