Systemic drug administration often causes off-target effects, limiting the efficacy of advanced therapies. Targeted drug delivery approaches increase local drug concentrations at the diseased site while minimizing systemic drug exposure. We present a...
Interindividual variation in biological responses to physiological stimuli is a widely recognized phenomenon. However, effective computational tools for identifying the individual-specific mechanisms remain limited. We present the bioreaction-variati...
Cancer immunology, immunotherapy : CII
Nov 12, 2025
Matrix stiffness is a defining feature of pancreatic ductal adenocarcinoma (PDAC) and drives malignant progression through mechanisms that remain poorly understood. Using an ensemble machine learning approach, we integrated multiomics data from 886 p...
Journal of cancer research and clinical oncology
Nov 8, 2025
AIM: Vasculogenic mimicry (VM), a process in which cancer cells form endothelial cell-independent vascular networks, is a hallmark of tumor aggressiveness in lung adenocarcinoma (LUAD) and supports tumor growth and metastasis. This study aims to iden...
Lupus nephritis (LN), a severe renal complication of systemic lupus erythematosus (SLE), results from immune abnormalities. Qingre Kasen granules (QS), which have chicory as the main ingredient, play a significant role in treating various inflammator...
Despite the success of messenger RNA (mRNA) COVID-19 vaccines, extending this modality to more diseases necessitates substantial enhancements. We present GEMORNA, a generative RNA model that uses transformer architectures tailored for mRNA coding seq...
Cytotoxic T cells (CD8) play a pivotal role in immunosurveillance by identifying and eliminating tumor cells. However, the onset of CD8 T cell exhaustion, characterized by overexpression of immune checkpoint receptors, impairs their function, allowin...
Proceedings of the National Academy of Sciences of the United States of America
Nov 3, 2025
Self-assembling protein nanoparticles are being increasingly utilized in the design of next-generation vaccines due to their ability to induce antibody responses of superior magnitude, breadth, and durability. Computational protein design offers a ro...
(Z)-endoxifen (endoxifen) is the active metabolite of tamoxifen. Endoxifen is a potent antiestrogen that binds and blocks estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). Early-phase clinical trials have shown that endoxifen has promis...
Sleep-wake states bidirectionally interact with epilepsy and seizures, but the mechanisms are unknown. A barrier to comprehensive characterization and the study of mechanisms has been the difficulty of annotating large chronic recording datasets. To ...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.