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Decoding dynamic brain networks in Parkinson's disease with temporal attention.
Scientific reports
May 29, 2025
Detecting brief, clinically meaningful changes in brain activity is crucial for understanding neurological disorders. Conventional imaging analyses often overlook these subtle events due to computational demands. IMPACT (Integrative Multimodal Pipeli...
Menopausal hormone therapy and the female brain: Leveraging neuroimaging and prescription registry data from the UK Biobank cohort.
eLife
May 29, 2025
BACKGROUND: Menopausal hormone therapy (MHT) is generally thought to be neuroprotective, yet results have been inconsistent. Here, we present a comprehensive study of MHT use and brain characteristics in females from the UK Biobank.
Inflammatory biomarkers as predictors for unlocking antidepressant efficacy: Assessing predictive value and risk stratification in major depressive disorder in a prospective longitudinal study.
Journal of affective disorders
May 28, 2025
BACKGROUND: Major depressive disorder (MDD) is characterized by significant heterogeneity in treatment response, with inflammation hypothesized to play a role in its pathophysiology. Peripheral inflammatory biomarkers, such as the neutrophil-to-lymph...
Contrastive functional connectivity defines neurophysiology-informed symptom dimensions in major depression.
Cell reports. Medicine
May 28, 2025
Major depressive disorder (MDD) is highly heterogeneous, posing challenges for effective treatment due to complex interactions between clinical symptoms and neurobiological features. To address this, we apply contrastive principal-component analysis ...
An integrated analytical approach for biomarker discovery in esophageal cancer: Combining trace element and oxidative stress profiling with machine learning.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
May 28, 2025
BACKGROUND: Early detection of esophageal squamous cell carcinoma (ESCC) significantly improves survival rates, yet reliable biochemical biomarkers for early diagnosis remain limited. The aim of this study is to identify potential early diagnostic bi...
Deep learning for predicting invasive recurrence of ductal carcinoma in situ: leveraging histopathology images and clinical features.
EBioMedicine
May 28, 2025
BACKGROUND: Ductal Carcinoma In Situ (DCIS) can progress to ipsilateral invasive breast cancer (IBC) but over 75% of DCIS lesions do not progress if untreated. Currently, DCIS that might progress to IBC cannot reliably be identified. Therefore, most ...
Detecting Tardive Dyskinesia Using Video-Based Artificial Intelligence.
The Journal of clinical psychiatry
May 28, 2025
Tardive dyskinesia (TD) is a late-onset adverse effect of dopamine receptor-blocking medications, characterized by involuntary movements primarily affecting the mouth, though other body parts may be involved. Severity of TD varies from mild to debil...
Performance of a novel multimodal large language model in ınterpreting meibomian glands quantitatively and qualitatively.
International ophthalmology
May 28, 2025
PURPOSE: To evaluate the performance of a multimodal large language model (LLM), Claude 3.5 Sonnet, in interpreting meibography images for Meibomian gland dropout grading and morphological abnormality detection.
Improving ACS prediction in T2DM patients by addressing false records in electronic medical records using propensity score.
Scientific reports
May 28, 2025
Our study aims to improve the prediction performance of machine learning (ML) models by addressing false records (i.e., false positive, false negative, or missingness) in binary categorical variables in electronic medical records (EMRs) using propens...
MicroRNA signature predicts post operative atrial fibrillation after coronary artery bypass grafting.
Scientific reports
May 28, 2025
Early detection of atrial fibrillation (AFib) is crucial for altering its natural progression and complication profile. Traditional demographic and lifestyle factors often fail as predictors of AFib. This study investigated pre-operative, circulating...
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