AIMC Topic: NF-kappa B

Clear Filters Showing 1 to 10 of 40 articles

Preclinical evidence construction for epigallocatechin-3-gallate against non-alcoholic fatty liver disease: a meta-analysis and machine learning study.

Phytomedicine : international journal of phytotherapy and phytopharmacology Apr 10, 2025
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant health concern worldwide, exhibiting an increasing incidence that necessitates immediate intervention. Epigallocatechin-3-gallate (EGCG) has shown significant pharmaco...
NF-kappa B Lipid Metabolism Non-alcoholic Fatty Liver Disease Catechin Humans Machine Learning Animals Antioxidants
View on PubMed DOI

Screening of BindingDB database ligands against EGFR, HER2, Estrogen, Progesterone and NF-κB receptors based on machine learning and molecular docking.

Computers in biology and medicine Oct 25, 2024
Breast cancer, the second most prevalent cancer among women worldwide, necessitates the exploration of novel therapeutic approaches. To target the four subgroups of breast cancer "hormone receptor-positive and HER2-negative, hormone receptor-positive...
Humans Receptor, ErbB-2 Machine Learning ErbB Receptors Receptors, Estrogen Female Receptors, Progesterone Breast Neoplasms Databases, Protein Molecular Docking Simulation NF-kappa B Ligands
View on PubMed DOI

Artificial intelligence-driven multiomics predictive model for abdominal aortic aneurysm subtypes to identify heterogeneous immune cell infiltration and predict disease progression.

International immunopharmacology Jul 8, 2024
BACKGROUND: Abdominal aortic aneurysm (AAA) poses a significant health risk and is influenced by various compositional features. This study aimed to develop an artificial intelligence-driven multiomics predictive model for AAA subtypes to identify he...
Humans Artificial Intelligence Female NF-kappa B Computed Tomography Angiography Disease Progression Aged Chemokine CXCL1 Multiomics Neutrophils Aortic Aneurysm, Abdominal Male Middle Aged
View on PubMed DOI

Design of target specific peptide inhibitors using generative deep learning and molecular dynamics simulations.

Nature communications Feb 21, 2024
We introduce a computational approach for the design of target-specific peptides. Our method integrates a Gated Recurrent Unit-based Variational Autoencoder with Rosetta FlexPepDock for peptide sequence generation and binding affinity assessment. Sub...
Peptides beta Catenin Deep Learning Protein Binding NF-kappa B Molecular Dynamics Simulation
View on PubMed DOI

Mechanism of TNF- α inducing apoptosis and autophagy of chondrocytes by activating NF- κ B signal pathway.

Cellular and molecular biology (Noisy-le-Grand, France) Dec 31, 2023
This study aimed to explore the mechanism of apoptosis and autophagy of chondrocytes induced by tumor necrosis factor α (TNA-α) by activating the NF-κB signal pathway. For this purpose, 24 SD rats were selected for feeding. The knee cartilage was cut...
Tumor Necrosis Factor-alpha Cells, Cultured NF-kappa B Interleukin-6 NF-KappaB Inhibitor alpha Chondrocytes Interleukin-1 Animals Interleukin-12 Signal Transduction RNA, Messenger Rats, Sprague-Dawley Rats Apoptosis Autophagy
View on PubMed DOI

High-Content Image-Based Screening and Deep Learning for the Detection of Anti-Inflammatory Drug Leads.

Chembiochem : a European journal of chemical biology Nov 7, 2023
We developed a high-content image-based screen that utilizes the pro-inflammatory stimulus lipopolysaccharide (LPS) and murine macrophages (RAW264.7) with the goal of enabling the identification of novel anti-inflammatory lead compounds. We screened ...
Lipopolysaccharides NF-kappa B Anti-Inflammatory Agents Deep Learning Mice Nitric Oxide Cytokines Animals
View on PubMed DOI

E. globulus leaf EO exhibits anti-inflammatory effects by regulating GSDMD-mediated pyroptosis, thereby alleviating neurological impairment and neuroinflammation in experimental stroke mice.

Journal of ethnopharmacology Oct 30, 2023
ETHNOPHARMACOLOGICAL RELEVANCE: Aromatic and medicinal plants continue to be a major component of alternative and traditional medicine in the developing countries. Eucalyptus globulus (Labill.) is being employed to cultivation and production in China...
NLR Family, Pyrin Domain-Containing 3 Protein Pyroptosis Stroke Infarction, Middle Cerebral Artery DNA-Binding Proteins Neuroinflammatory Diseases Microglia NF-kappa B Anti-Inflammatory Agents Rats, Sprague-Dawley Animals Lipopolysaccharides Mice Plant Leaves Rats Inflammation Anti-Infective Agents Tumor Necrosis Factor-alpha Interleukin-6
View on PubMed DOI

The water-soluble subfraction from Artemisia argyi alleviates LPS-induced inflammatory responses via multiple pathways and targets in vitro and in vivo.

Journal of ethnopharmacology Oct 28, 2023
ETHNOPHARMACOLOGICAL RELEVANCE: As a traditional Chinese medicine, Artemisia argyi has been used medicinally and eaten for more than 2000 years in China. It is widely reported in treating inflammatory diseases such as eczema, dermatitis, arthritis, a...
NF-kappa B Anti-Inflammatory Agents Proto-Oncogene Proteins c-akt Matrix Metalloproteinase 9 Animals Plant Extracts Artemisia Molecular Docking Simulation Inflammation Lipopolysaccharides Water Mice RNA, Messenger
View on PubMed DOI

β-D-Glucan promotes NF-κB activation and ameliorates high-LET carbon-ion irradiation-induced human umbilical vein endothelial cell injury.

Turkish journal of medical sciences Sep 21, 2023
BACKGROUND/AIM: Heavy-ion irradiation seriously perturbs cellular homeostasis and thus damages cells. Vascular endothelial cells (ECs) play an important role in the pathological process of radiation damage. Protecting ECs from heavy-ion radiation is ...
beta-Glucans Cell Survival Humans Radiation-Protective Agents NF-kappa B Apoptosis Human Umbilical Vein Endothelial Cells Reactive Oxygen Species DNA Damage
View on PubMed DOI

Identifying Drug Targets of Oral Squamous Cell Carcinoma through a Systems Biology Method and Genome-Wide Microarray Data for Drug Discovery by Deep Learning and Drug Design Specifications.

International journal of molecular sciences Sep 8, 2022
In this study, we provide a systems biology method to investigate the carcinogenic mechanism of oral squamous cell carcinoma (OSCC) in order to identify some important biomarkers as drug targets. Further, a systematic drug discovery method with a dee...
Head and Neck Neoplasms NF-kappa B Mouth Neoplasms Metformin Gefitinib Deep Learning Systems Biology Humans Gene Expression Regulation, Neoplastic Biomarkers Squamous Cell Carcinoma of Head and Neck Biomarkers, Tumor Carcinoma, Squamous Cell Drug Design Drug Discovery
View on PubMed DOI
Popular Topics
Recent Journals