AIMC Topic: Polysaccharides

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Structural characterization and osteogenic bioactivity of a sulfated polysaccharide from pacific abalone (Haliotis discus hannai Ino).

Carbohydrate polymers
Bone morphogenic protein-2 (BMP-2) is known to promote osteogenesis. To find novel adjuvants to enhance the activity of BMP-2, the present study investigated the structure BMP-2-induced osteogenic activity of a water-soluble polysaccharide from the g...

Digging deep into Golgi phenotypic diversity with unsupervised machine learning.

Molecular biology of the cell
The synthesis of glycans and the sorting of proteins are critical functions of the Golgi apparatus and depend on its highly complex and compartmentalized architecture. High-content image analysis coupled to RNA interference screening offers opportuni...

Difficulties in thickened water ingestion in healthy subjects.

Clinical nutrition ESPEN
BACKGROUND: For some patients with dysphagia who have airway aspiration, it is not possible to drink water as a thin liquid, as they need their water to be thickened.

Optimization conditions for extracting polysaccharide from Angelica sinensis and its antioxidant activities.

Journal of food and drug analysis
In this study, polysaccharides from Angelica sinensis were extracted using the ultrasound-assisted extraction method. Based on the results of single factor experiments and orthogonal tests, three independent variables-water/raw material ratio, ultras...

A Knowledge-Based System for Display and Prediction of O-Glycosylation Network Behaviour in Response to Enzyme Knockouts.

PLoS computational biology
O-linked glycosylation is an important post-translational modification of mucin-type protein, changes to which are important biomarkers of cancer. For this study of the enzymes of O-glycosylation, we developed a shorthand notation for representing Ga...

Comparison of bleeding risks related to venous thromboembolism prophylaxis in laparoscopic vs open colorectal cancer surgery: a multicenter study in Japanese patients.

American journal of surgery
BACKGROUND: Venous thromboembolism is the most common preventable cause of hospital death. The objective of this study was to clarify risk factors for postoperative bleeding related to thromboprophylaxis after laparoscopic colorectal cancer surgery.

Rheological properties of a polysaccharide from floral mushrooms cultivated in Huangshan Mountain.

Carbohydrate polymers
A polysaccharide fraction (FMPS) was isolated from floral mushrooms cultivated in Huangshan Mountain, and the rheological properties of FMPS in aqueous solutions were investigated. The FMPS solution showed shear-thinning behavior at 25°C. Dynamic vis...

Automated, high-throughput serum glycoprofiling platform.

Integrative biology : quantitative biosciences from nano to macro
Complex carbohydrates are rapidly becoming excellent biomarker candidates because of their high sensitivity to pathological changes. However, the discovery of clinical glycobiomarkers has been slow, due to the scarcity of high-throughput glycoanalyti...

Classifying Type 2 Diabetes Using N-Glycan Profiling and Machine Learning Algorithms.

Studies in health technology and informatics
BACKGROUND: Type 2 diabetes (T2D) continues to present a global public health challenge due to its increasing prevalence. Early diagnosis is critical for preventing complications, but current screening methods often fail to detect early diabetic cond...