AIMC Topic: Proteolysis

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A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes.

Nature communications Aug 21, 2020
Chemoproteomics is a key technology to characterize the mode of action of drugs, as it directly identifies the protein targets of bioactive compounds and aids in the development of optimized small-molecule compounds. Current approaches cannot identif...
Botrytis Proteomics Proteome Machine Learning Mass Spectrometry Drug Delivery Systems Cell Survival Drug Discovery Ligands HeLa Cells Protein Binding Saccharomyces cerevisiae Computational Biology Proteolysis Humans Binding Sites Phosphotransferases
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The proteome landscape of the kingdoms of life.

Nature Jun 17, 2020
Proteins carry out the vast majority of functions in all biological domains, but for technological reasons their large-scale investigation has lagged behind the study of genomes. Since the first essentially complete eukaryotic proteome was reported, ...
Peptides Deep Learning Ion Transport Glycolysis Proteomics Animals Homeostasis Proteolysis Carbohydrate Metabolism Protein Folding Protein Biosynthesis Proteome Oxidation-Reduction Chromatography Classification Species Specificity Photosynthesis Bacteroides Iron-Sulfur Proteins
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An Intelligent DNA Nanorobot with Enhanced Protein Lysosomal Degradation of HER2.

Nano letters Jun 5, 2019
DNA nanorobots have emerged as new tools for nanomedicine with the potential to ameliorate the delivery and anticancer efficacy of various drugs. DNA nanostructures have been considered one of the most promising nanocarriers. In the present study, we...
Receptor, ErbB-2 Proteolysis Endocytosis Animals Aptamers, Nucleotide Mice Mice, Nude MCF-7 Cells Robotics DNA Lysosomes Xenograft Model Antitumor Assays Humans Female Breast Neoplasms Drug Delivery Systems
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Intra-articular collagenase injection increases range of motion in a rat knee flexion contracture model.

Drug design, development and therapy Dec 21, 2017
OBJECTIVES: A knee joint contracture, a loss in passive range of motion (ROM), can be caused by prolonged immobility. In a rat knee immobilization flexion contracture model, the posterior capsule was shown to contribute to an irreversible limitation ...
Hindlimb Suspension Joint Capsule Joints Biomechanical Phenomena Animals Male Time Factors Injections, Intra-Articular Rats, Sprague-Dawley Collagen Type I Proteolysis Disease Models, Animal Collagen Type III Recovery of Function Contracture Collagenases Range of Motion, Articular
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Evaluation of Aristolochia indica L. and Piper nigrum L. methanol extract against centipede Scolopendra moristans L. using Wistar albino rats and screening of bioactive compounds by high pressure liquid chromatography: a polyherbal formulation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Nov 28, 2017
The present study was aimed to explore the anti-venom activity of Aristolochia indica and Piper nigrum plants against the centipede (Scolopendra moristans) envenomation in animal model. In vtiro phytochemical, antioxidant and blocking of proteolysis ...
Venoms Organ Specificity Phytotherapy Piper nigrum Proteolysis Mice Phytochemicals Toxicity Tests, Acute Antioxidants Humans Methanol Annelida Plant Extracts Chromatography, High Pressure Liquid Animals Rats, Wistar Antivenins Behavior, Animal Antineoplastic Agents Lipids Cell Line, Tumor Aristolochia Electrolytes
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In silico identification of milk antihypertensive di- and tripeptides involved in angiotensin I-converting enzyme inhibitory activity.

Nutrition research (New York, N.Y.) Jul 28, 2017
Identification of bioactive milk peptides could improve food technology through improved selection of food supplements with a focus on antihypertensive properties. We hypothesized that angiotensin I-converting enzyme (ACE) inhibitory activities of mi...
Milk Proteins Hydrogen Bonding Models, Molecular Peptidyl-Dipeptidase A Peptide Fragments Proteolysis Dipeptides Binding Sites Hydrophobic and Hydrophilic Interactions Molecular Docking Simulation Expert Systems Cattle Catalytic Domain Humans Computational Biology Oligopeptides Animals Dietary Supplements Angiotensin-Converting Enzyme Inhibitors Antihypertensive Agents Quantitative Structure-Activity Relationship Protein Conformation
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Ultrasensitive Protease Sensors Using Selective Affinity Binding, Selective Proteolytic Reaction, and Proximity-Dependent Electrochemical Reaction.

Analytical chemistry Nov 30, 2016
The development of a fast and ultrasensitive protease detection method is a challenging task. This paper reports ultrasensitive protease sensors exploiting (i) selective affinity binding, (ii) selective proteolytic reaction, and (iii) proximity-depen...
Graphite Oligopeptides Tin Compounds Trypsin Proteolysis Aminophenols Oxidation-Reduction Electrochemical Techniques Limit of Detection Oxides Electrodes Immunoglobulin G
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The Proteasix Ontology.

Journal of biomedical semantics Jun 4, 2016
BACKGROUND: The Proteasix Ontology (PxO) is an ontology that supports the Proteasix tool; an open-source peptide-centric tool that can be used to predict automatically and in a large-scale fashion in silico the proteases involved in the generation of...
Software Computational Biology Proteolysis Gene Ontology Peptide Hydrolases
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Structure-based artificial intelligence-aided design of MYC-targeting degradation drugs for cancer therapy.

Biochemical and biophysical research communications Jun 20, 2025
The MYC protein is an oncoprotein that plays a crucial role in various cancers. Although its significance has been well recognized in research, the development of drugs targeting MYC remains relatively slow. In this study, we developed a novel MYC pe...
Humans Artificial Intelligence Cell Proliferation Apoptosis Autophagy Proteolysis Proto-Oncogene Proteins c-myc Neoplasms Peptides Drug Design Antineoplastic Agents Cell Line, Tumor
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ET-PROTACs: modeling ternary complex interactions using cross-modal learning and ternary attention for accurate PROTAC-induced degradation prediction.

Briefings in bioinformatics Nov 22, 2024
MOTIVATION: Accurately predicting the degradation capabilities of proteolysis-targeting chimeras (PROTACs) for given target proteins and E3 ligases is important for PROTAC design. The distinctive ternary structure of PROTACs presents a challenge to t...
Ubiquitin-Protein Ligases Proteolysis Proteolysis Targeting Chimera Humans Neural Networks, Computer Proteins
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