Immunotherapy has revolutionized hematologic cancer treatment, yet responses remain unpredictable due to primary resistance, relapse, and life-threatening toxicities. Conventional biomarkers fail to capture the complexity of tumor-immune interactions...
Recent advances in single-cell multi-omics technologies have revolutionized cellular analysis, enabling comprehensive exploration of cellular heterogeneity, developmental trajectories, and disease mechanisms at unprecedented resolution. Foundation mo...
Lyme neuroborreliosis (LNB), a nervous system infection caused by tick-borne spirochetes of the Borrelia burgdorferi sensu lato complex, is among the most frequent bacterial infections of the nervous system in Europe. Early diagnosis and continuous m...
Phytomedicine : international journal of phytotherapy and phytopharmacology
Oct 24, 2025
BACKGROUND: As global health challenges continue to evolve, herbal medicines (HMs) have garnered significant scientific interest as a valuable resource for treating complex diseases. However, the chemical complexity of HMs presents considerable chall...
Biochemical and biophysical research communications
Oct 24, 2025
BACKGROUND: Aortic valve stenosis with coronary artery disease (AS-CAD) represents a common yet complex cardiovascular comorbidity, characterized by multifactorial pathogenesis and a lack of specific serum biomarkers. These limitations hinder early d...
Environmental challenges such as drought, salinity, heavy metal contamination, and nutrient deficiencies threaten global agricultural productivity and food security. These stressors drastically reduce crop yields, necessitating innovative solutions. ...
Rapid and accurate diagnosis of emerging inflammatory illnesses is challenging due to overlapping clinical features with existing conditions. We demonstrate an approach that integrates proteomic analysis with machine learning to identify diagnostic p...
Signal transduction and targeted therapy
Oct 13, 2025
Nearly 30% of patients with schizophrenia respond inadequately to current antipsychotics, with unclear markers and mechanisms of antipsychotic efficacy. A total of 208 patients with schizophrenia treated for 6 weeks with oral paliperidone were analyz...
: Perfluorooctane sulphonate (PFOS) is a persistent environmental contaminant with well-documented hepatotoxic properties. Nicotinamide, the amide derivative of vitamin B3, is widely utilized as a nutritional supplement and exerts multiple biological...
Journal of chemical information and modeling
Oct 10, 2025
Phosphorylation dynamically orchestrates the protein-protein interaction (PPI) network that governs cellular signaling, and its dysregulation frequently drives malignant transformation and neurodegeneration. We present PhosPPI-SEQ, an interpretable d...
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