AIMC Topic: Pyroptosis

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Integrating bioinformatics and machine learning to uncover lncRNA LINC00269 as a key regulator in Parkinson's disease via pyroptosis pathways.

European journal of medical research Dec 18, 2024
BACKGROUND: Pyroptosis, a specific type of programmed cell death, which has become a significant factor to Parkinson's disease (PD). Concurrently, long non-coding RNAs (lncRNAs) have garnered attention for their regulatory roles in neurodegenerative ...
Humans Machine Learning Mice Computational Biology Parkinson Disease Animals Gene Expression Profiling Gene Regulatory Networks RNA, Long Noncoding Pyroptosis
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Construction of the miRNA/Pyroptosis-Related Molecular Regulatory Axis in Abdominal Aortic Aneurysm: Evidence From Transcriptome Data Combined With Multiple Machine Learning Approaches Followed by Experiment Validation.

Journal of immunology research Oct 30, 2024
Abdominal aortic aneurysm (AAA) represents a permanent and localized widening of the abdominal aorta, posing a potentially lethal risk of aortic rupture. Several recent studies have highlighted the role of pyroptosis, a pro-inflammatory programed ce...
Female Male Gene Expression Profiling Transcriptome Gene Regulatory Networks Computational Biology Humans Machine Learning Biomarkers Pyroptosis Gene Expression Regulation Databases, Genetic MicroRNAs Aortic Aneurysm, Abdominal
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Dynamic changes in pyroptosis following spinal cord injury and the identification of crucial molecular signatures through machine learning and single-cell sequencing.

Journal of pharmaceutical and biomedical analysis Aug 26, 2024
The pathological cascade of spinal cord injury (SCI) is highly intricate. The onset of neuroinflammation can exacerbate the extent of damage. Pyroptosis is a form of inflammation-linked programmed cell death (PCD), the inhibition of pyroptosis can pa...
Spinal Cord Injuries Microglia Pyroptosis Spinal Cord Single-Cell Analysis Mice Disease Models, Animal Mice, Inbred C57BL Cell Line Neuroinflammatory Diseases Machine Learning Animals Male
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Identification of Pyroptosis-Related Molecular Subtypes and Diagnostic Model development in Major Depressive Disorder.

Molecular biotechnology Aug 23, 2024
Major depressive disorder (MDD) is a prevalent psychological disorder associated with inflammation, with complex pathological mechanisms. Pyroptosis has been suggested to contribute to inflammation in central nervous system diseases. Little research,...
Humans Machine Learning Biomarkers Databases, Genetic Cluster Analysis Pyroptosis Depressive Disorder, Major Gene Expression Profiling Gene Regulatory Networks
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Identification and validation of a pyroptosis-related signature in identifying active tuberculosis via a deep learning algorithm.

Frontiers in cellular and infection microbiology Nov 1, 2023
INTRODUCTION: Active tuberculosis (ATB), instigated by Mycobacterium tuberculosis (M.tb), rises as a primary instigator of morbidity and mortality within the realm of infectious illnesses. A significant portion of M.tb infections maintain an asymptom...
Tuberculosis Algorithms Latent Tuberculosis Deep Learning Pyroptosis Humans
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E. globulus leaf EO exhibits anti-inflammatory effects by regulating GSDMD-mediated pyroptosis, thereby alleviating neurological impairment and neuroinflammation in experimental stroke mice.

Journal of ethnopharmacology Oct 30, 2023
ETHNOPHARMACOLOGICAL RELEVANCE: Aromatic and medicinal plants continue to be a major component of alternative and traditional medicine in the developing countries. Eucalyptus globulus (Labill.) is being employed to cultivation and production in China...
NLR Family, Pyrin Domain-Containing 3 Protein Pyroptosis Stroke Microglia NF-kappa B Anti-Inflammatory Agents Infarction, Middle Cerebral Artery DNA-Binding Proteins Interleukin-6 Animals Mice Rats Anti-Infective Agents Lipopolysaccharides Inflammation Tumor Necrosis Factor-alpha Plant Leaves Rats, Sprague-Dawley Neuroinflammatory Diseases
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Mechanistic role of pyroptosis in Kawasaki disease: An integrative bioinformatics analysis of immune dysregulation, machine learning-based biomarker discovery, WGCNA, and drug repurposing insights.

PloS one Jan 1, 2025
Kawasaki disease (KD) is an acute vasculitis that primarily affects children under five and is a leading cause of acquired heart disease in this age group. Despite the standard treatment with intravenous immunoglobulin (IVIG), approximately 10-20% of...
Drug Repositioning Pyroptosis Molecular Docking Simulation Myeloid Differentiation Factor 88 Humans Gene Expression Profiling Machine Learning Transcriptome Biomarkers Gene Regulatory Networks Computational Biology Mucocutaneous Lymph Node Syndrome
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Machine Learning-derived Multi-omics Prognostic Signature of Pyroptosis-related lncRNA with Regard to ZKSCAN2-DT and Tumor Immune Infiltration in Colorectal Cancer.

Combinatorial chemistry & high throughput screening Jan 1, 2024
BACKGROUND: Colorectal cancer (CRC) has become the most prevalent gastrointestinal malignant tumor, ranking third (10.2%) in incidence and second (9.2%) in death among all malignancies globally. The most common histological subtype of CRC is colon ad...
RNA, Long Noncoding Pyroptosis Machine Learning Prognosis Colorectal Neoplasms Tumor Microenvironment Biomarkers, Tumor Humans Multiomics
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