AIMC Topic: Pyroptosis

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E. globulus leaf EO exhibits anti-inflammatory effects by regulating GSDMD-mediated pyroptosis, thereby alleviating neurological impairment and neuroinflammation in experimental stroke mice.

Journal of ethnopharmacology Oct 30, 2023
ETHNOPHARMACOLOGICAL RELEVANCE: Aromatic and medicinal plants continue to be a major component of alternative and traditional medicine in the developing countries. Eucalyptus globulus (Labill.) is being employed to cultivation and production in China...
Anti-Infective Agents Tumor Necrosis Factor-alpha Interleukin-6 Animals Mice Rats Inflammation Rats, Sprague-Dawley Lipopolysaccharides Plant Leaves Neuroinflammatory Diseases Microglia NF-kappa B Anti-Inflammatory Agents NLR Family, Pyrin Domain-Containing 3 Protein Pyroptosis Stroke Infarction, Middle Cerebral Artery DNA-Binding Proteins
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Mechanistic role of pyroptosis in Kawasaki disease: An integrative bioinformatics analysis of immune dysregulation, machine learning-based biomarker discovery, WGCNA, and drug repurposing insights.

PloS one Jan 1, 2025
Kawasaki disease (KD) is an acute vasculitis that primarily affects children under five and is a leading cause of acquired heart disease in this age group. Despite the standard treatment with intravenous immunoglobulin (IVIG), approximately 10-20% of...
Humans Machine Learning Biomarkers Molecular Docking Simulation Gene Expression Profiling Transcriptome Gene Regulatory Networks Computational Biology Mucocutaneous Lymph Node Syndrome Drug Repositioning Pyroptosis Myeloid Differentiation Factor 88
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Machine Learning-derived Multi-omics Prognostic Signature of Pyroptosis-related lncRNA with Regard to ZKSCAN2-DT and Tumor Immune Infiltration in Colorectal Cancer.

Combinatorial chemistry & high throughput screening Jan 1, 2024
BACKGROUND: Colorectal cancer (CRC) has become the most prevalent gastrointestinal malignant tumor, ranking third (10.2%) in incidence and second (9.2%) in death among all malignancies globally. The most common histological subtype of CRC is colon ad...
Humans Machine Learning Prognosis Colorectal Neoplasms Tumor Microenvironment Biomarkers, Tumor Multiomics RNA, Long Noncoding Pyroptosis
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