AIMC Topic: Randomized Controlled Trials as Topic
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Enhancing early detection and treatment of psychosis in Germany: a protocol for the health economic evaluation of an artificial intelligence-guided complex intervention.
BMJ open
Jun 18, 2025
INTRODUCTION: Psychosis, characterised by chronic symptoms often emerging in youth, imposes a substantial burden on individuals and healthcare systems. While early detection and intervention can mitigate this burden, there is limited evidence on the ...
Research on the evaluation and rehabilitation training system of upper limb motor function for poststroke patients based on artificial intelligence: a study protocol for a randomized controlled trial.
Trials
Jun 13, 2025
BACKGROUND: Stroke-induced upper limb dysfunction requires functional assessment and rehabilitation. The intelligent rehabilitation assessment and virtual reality training system for upper limb motor function in stroke can accurately and objectively ...
AI-empowered health coaching for university students: A mixed-method process evaluation.
Computers in biology and medicine
Jun 11, 2025
BACKGROUND: Artificial Intelligence (AI)-empowered health coaching (HC) has the potential to enhance HC effectiveness by providing real-time, evidence-based support. However, integrating AI into live HC sessions presents challenges, particularly in r...
A multi-site randomized clinical trial of socially assistive robots on engaging older adults with cognitive impairment residing in long-term care settings: A protocol paper.
Contemporary clinical trials
Jun 6, 2025
Apathy is common in persons with dementias, especially those in long-term care facilities (LTCs). Few pharmacologic options exist; a major strategy is to foster engagement in social, physical, and cognitive activities, but requires extensive personne...
Efficacy and safety of first-line CDK4/6 inhibitors plus AI therapy for patients with HR +/HER2- advanced breast cancer: a network meta-analysis.
BMC cancer
May 8, 2025
BACKGROUND: CDK4/6 inhibitors plus aromatase inhibitors (AI) significantly improve the therapeutic effect of initial treatment for HR + /HER2- advanced breast cancer. However, there is a lack of head-to-head randomized controlled trials involving the...
Cyclin-Dependent Kinase 6
Receptor, ErbB-2
Network Meta-Analysis as Topic
Receptors, Estrogen
Antineoplastic Combined Chemotherapy Protocols
Aromatase Inhibitors
Aminopyridines
Humans
Purines
Protein Kinase Inhibitors
Treatment Outcome
Receptors, Progesterone
Female
Benzimidazoles
Cyclin-Dependent Kinase 4
Randomized Controlled Trials as Topic
Progression-Free Survival
Breast Neoplasms
Enriching patient populations in ICU trials: reducing heterogeneity through machine learning.
Current opinion in critical care
May 2, 2025
PURPOSE OF REVIEW: Despite the pivotal role of randomized controlled trials (RCTs) in critical care research, many have failed to demonstrate significant benefits, particularly in nutrition interventions. This review highlights how patient heterogene...
Recent advances in therapeutic probiotics: insights from human trials.
Clinical microbiology reviews
Apr 22, 2025
SUMMARYRecent advances in therapeutic probiotics have shown promising results across various health conditions, reflecting a growing understanding of the human microbiome's role in health and disease. However, comprehensive reviews integrating the di...
Testing a Machine Learning-Based Adaptive Motivational System for Socioeconomically Disadvantaged Smokers (Adapt2Quit): Protocol for a Randomized Controlled Trial.
JMIR research protocols
Apr 16, 2025
BACKGROUND: Individuals who are socioeconomically disadvantaged have high smoking rates and face barriers to participating in smoking cessation interventions. Computer-tailored health communication, which is focused on finding the most relevant messa...
Using the counterfactual framework to estimate non-intention-to-treat estimands in randomised controlled trials: A methodological scoping review.
Contemporary clinical trials
Apr 11, 2025
BACKGROUND: Randomised controlled trials (RCTs) commonly estimate intention-to-treat (ITT) estimands. However, when nonadherence to assigned treatment occurs, ITT estimands reflect the effect of being offered treatment, rather than adhering to it and...
Artificial intelligence-based personalised rituximab treatment protocol in membranous nephropathy (iRITUX): protocol for a multicentre randomised control trial.
BMJ open
Apr 2, 2025
INTRODUCTION: Membranous nephropathy is an autoimmune kidney disease and the most common cause of nephrotic syndrome in non-diabetic Caucasian adults. Rituximab is now recommended as first-line therapy for membranous nephropathy. However, Kidney Dise...
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