AIMC Topic: RNA, Long Noncoding
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From correlation to causation: unraveling the role of long non-coding RNAs in COVID-19 pathogenesis.
Virology journal
Aug 28, 2025
Heydari et al. present an intriguing study examining the role of three long non-coding RNAs (lncRNAs)-H19, taurine upregulated gene 1 (TUG1), and colorectal neoplasia differentially expressed (CRNDE)-in the context of Coronavirus Disease 2019 (COVID-...
Bioinformatics analysis of Rho-signal transduction genes in postmenopausal osteoporosis and periodontitis.
Scientific reports
Aug 5, 2025
Postmenopausal osteoporosis (PMOP) increases the risk of periodontitis (PD), yet the shared mechanisms remain unclear. Rho-signal transduction genes may play a role due to their involvement in bone remodeling. This study aimed to explore Rho-related ...
Multi-transcriptomics predicts clinical outcome in systemically untreated breast cancer patients with extensive follow-up.
Breast cancer research : BCR
Jul 15, 2025
BACKGROUND: Prognostic tools for determining patients with indolent breast cancers (BCs) are far from optimal, leading to extensive overtreatment. Several studies have demonstrated mRNAs, lncRNAs and miRNAs to have prognostic potential in BC. Because...
Machine learning combined with multi-omics to identify immune-related LncRNA signature as biomarkers for predicting breast cancer prognosis.
Scientific reports
Jul 4, 2025
This study developed an immune-related long non-coding RNAs (lncRNAs)-based prognostic signature by integrating multi-omics data and machine learning algorithms to predict survival and therapeutic responses in breast cancer patients. Utilizing transc...
Identification of MEG3 and MAPK3 as potential therapeutic targets for osteoarthritis through multiomics integration and machine learning.
Scientific reports
Jul 2, 2025
Knee osteoarthritis (KOA) is a prevalent degenerative joint disorder, yet its underlying molecular mechanisms remain puzzling. This study aimed to uncover the genes with a causal relationship to KOA using Mendelian randomization (MR), transcriptomic ...
LncRNAs regulates cell death in osteosarcoma.
Scientific reports
Jul 2, 2025
Despite improvements, prognosis in osteosarcoma patients remains poor, making it essential to identify additional and more robust therapeutic targets. Non-apoptotic receptor-mediated cell death (RCD), which plays a crucial role in the pathogenesis of...
Identification of key genes associated with cellular aging and mitochondria in acute myocardial infarction.
Scientific reports
Jul 1, 2025
Acute myocardial infarction (AMI) poses a significant global mortality burden. Utilizing bio informatics, this study explored cellular aging-related genes (CARGs) and mitochondrial-related genes (MRGs). in AMI Public AMI datasets were analyzed using ...
MLWNNR: LncRNA-Disease Association Prediction with Multi-Kernel Learning-Driven Weighted Nuclear Norm Regularization.
Interdisciplinary sciences, computational life sciences
Jun 23, 2025
Emerging evidence highlights long non-coding RNAs (lncRNAs) as pivotal regulators demonstrating significant linkages with diverse human pathologies through expression dynamics and regulatory cascades. This research endeavors to establish an algorithm...
Novel exosome-associated LncRNA model predicts colorectal cancer prognosis and drug response.
Hereditas
May 16, 2025
BACKGROUND: Exosomes are extracellular vesicles that carry various biological substances and have potential as functional mediators in cancers. However, little is known about special molecules in colorectal cancer (CRC) exosomes and their immunologic...
Construction of exosome non-coding RNA feature for non-invasive, early detection of gastric cancer patients by machine learning: a multi-cohort study.
Gut
May 7, 2025
BACKGROUND AND OBJECTIVE: Gastric cancer (GC) remains a prevalent and preventable disease, yet accurate early diagnostic methods are lacking. Exosome non-coding RNAs (ncRNAs), a type of liquid biopsy, have emerged as promising diagnostic biomarkers f...
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