AIMC Topic: Signal Transduction
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HOX cluster and their cofactors showed an altered expression pattern in eutopic and ectopic endometriosis tissues.
Reproductive biology and endocrinology : RB&E
Sep 1, 2021
Endometriosis is major gynecological disease that affects over 10% of women worldwide and 30%-50% of these women have pelvic pain, abnormal uterine bleeding and infertility. The cause of endometriosis is unknown and there is no definite cure mainly b...
Identification of conserved transcriptome features between humans and Drosophila in the aging brain utilizing machine learning on combined data from the NIH Sequence Read Archive.
PloS one
Aug 11, 2021
Aging is universal, yet characterizing the molecular changes that occur in aging which lead to an increased risk for neurological disease remains a challenging problem. Aging affects the prefrontal cortex (PFC), which governs executive function, lear...
The Emerging Role of Long Non-Coding RNAs and MicroRNAs in Neurodegenerative Diseases: A Perspective of Machine Learning.
Biomolecules
Jul 31, 2021
Neurodegenerative diseases (NDs) are characterized by progressive neuronal dysfunction and death of brain cells population. As the early manifestations of NDs are similar, their symptoms are difficult to distinguish, making the timely detection and d...
Automated machine learning optimizes and accelerates predictive modeling from COVID-19 high throughput datasets.
Scientific reports
Jul 23, 2021
COVID-19 outbreak brings intense pressure on healthcare systems, with an urgent demand for effective diagnostic, prognostic and therapeutic procedures. Here, we employed Automated Machine Learning (AutoML) to analyze three publicly available high thr...
Dual-Organ Transcriptomic Analysis of Rainbow Trout Infected With Through Co-Expression and Machine Learning.
Frontiers in immunology
Jul 8, 2021
is a major pathogen that causes a high mortality rate in trout farms. However, systemic responses to the pathogen and its interactions with multiple organs during the course of infection have not been well described. In this study, dual-organ transc...
Machine Learning to Support the Presentation of Complex Pathway Graphs.
IEEE/ACM transactions on computational biology and bioinformatics
Jun 3, 2021
Visualization of biological mechanisms by means of pathway graphs is necessary to better understand the often complex underlying system. Manual layout of such pathways or maps of knowledge is a difficult and time consuming process. Node duplication i...
Identification of potential genomic biomarkers for Parkinson's disease using data pooling of gene expression microarrays.
Biomarkers in medicine
May 14, 2021
In this study, we aimed to identify potential diagnostic biomarkers Parkinson's disease (PD) by exploring microarray gene expression data of PD patients. Differentially expressed genes associated with PD were screened from the GSE99039 dataset usin...
Pseudocell Tracer-A method for inferring dynamic trajectories using scRNAseq and its application to B cells undergoing immunoglobulin class switch recombination.
PLoS computational biology
May 3, 2021
Single cell RNA sequencing (scRNAseq) can be used to infer a temporal ordering of cellular states. Current methods for the inference of cellular trajectories rely on unbiased dimensionality reduction techniques. However, such biologically agnostic or...
STAT6 Transcription Factor
B-Lymphocytes
Supervised Machine Learning
Databases, Nucleic Acid
Models, Immunological
Receptors, Cytokine
Recombination, Genetic
Basic-Leucine Zipper Transcription Factors
Immunoglobulin Class Switching
NF-kappa B p50 Subunit
Mice
Computational Biology
Signal Transduction
Mice, Inbred C57BL
Gene Expression
Computer Simulation
Animals
Single-Cell Analysis
RNA-Seq
Neural Networks, Computer
Interleukin-4
Immunoglobulin G
Artificial Intelligence Approaches to Assessing Primary Cilia.
Journal of visualized experiments : JoVE
May 1, 2021
Cilia are microtubule based cellular appendages that function as signaling centers for a diversity of signaling pathways in many mammalian cell types. Cilia length is highly conserved, tightly regulated, and varies between different cell types and ti...
Artificial intelligence and leukocyte epigenomics: Evaluation and prediction of late-onset Alzheimer's disease.
PloS one
Mar 31, 2021
We evaluated the utility of leucocyte epigenomic-biomarkers for Alzheimer's Disease (AD) detection and elucidates its molecular pathogeneses. Genome-wide DNA methylation analysis was performed using the Infinium MethylationEPIC BeadChip array in 24 l...
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