AIMC Topic: Signal Transduction
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A neural network model predicts community-level signaling states in a diverse microbial community.
PLoS computational biology
Jun 24, 2019
Signal crosstalk within biological communication networks is common, and such crosstalk can have unexpected consequences for decision making in heterogeneous communities of cells. Here we examined crosstalk within a bacterial community composed of fi...
Nervous-Like Circuits in the Ribosome Facts, Hypotheses and Perspectives.
International journal of molecular sciences
Jun 14, 2019
In the past few decades, studies on translation have converged towards the metaphor of a "ribosome nanomachine"; they also revealed intriguing ribosome properties challenging this view. Many studies have shown that to perform an accurate protein synt...
Assessment of risk based on variant pathways and establishment of an artificial neural network model of thyroid cancer.
BMC medical genetics
May 28, 2019
BACKGROUND: This study aimed to establish an artificial neural network (ANN) model based on variant pathways to predict the risk of thyroid cancer.
Single-cell approaches to cell competition: High-throughput imaging, machine learning and simulations.
Seminars in cancer biology
May 18, 2019
Cell competition is a quality control mechanism in tissues that results in the elimination of less fit cells. Over the past decade, the phenomenon of cell competition has been identified in many physiological and pathological contexts, driven either ...
Systems Pharmacological Approach to Investigate the Mechanism of for Application to Alzheimer's Disease.
Molecules (Basel, Switzerland)
Apr 17, 2019
(OC)-a traditional Chinese medicine (TCM)-has been reported to have large numbers of flavonoids, alkaloids, and triterpenoids. The previous studies on OC for treating Alzheimer's disease (AD) only focused on single targets and its mechanisms, while ...
Analysis of differentially expressed genes in rheumatoid arthritis and osteoarthritis by integrated microarray analysis.
Journal of cellular biochemistry
Mar 4, 2019
BACKGROUND: Rheumatoid arthritis (RA) and osteoarthritis (OA) were two major types of joint diseases. This study aimed to explore the mechanism underlying OA and RA and analyze their difference by integrated analysis of multiple gene expression data ...
Oxidative Phosphorylation
Inhibitor of Apoptosis Proteins
Synovial Membrane
Osteoarthritis
Gene Expression Regulation
Gene Regulatory Networks
Gene Ontology
Arthritis, Rheumatoid
Oligonucleotide Array Sequence Analysis
Humans
Signal Transduction
Gene Expression Profiling
Chemokines
Protein Interaction Maps
Ubiquitin-Protein Ligases
Grape Seed Proanthocyanidin Extract Inhibits Human Esophageal Squamous Cancerous Cell Line ECA109 via the NF-B Signaling Pathway.
Mediators of inflammation
Dec 17, 2018
Esophageal squamous cell carcinoma is the most common type of squamous cell carcinoma. Grape seed proanthocyanidin extract (GSPE) is considered to exhibit anticancer activity against several different types of cancer. We aimed to determine whether GS...
Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-B/p65 Signaling in Chronic Radiculitis Rats.
Pain research & management
Dec 13, 2018
BACKGROUND: Oxygen/ozone therapy is a minimally invasive technique for the treatment of radiculitis from lumbar disc herniation. This study aimed at investigating whether intrathecal administration of low-concentration oxygen/ozone could attenuate ch...
Found In Translation: a machine learning model for mouse-to-human inference.
Nature methods
Nov 26, 2018
Cross-species differences form barriers to translational research that ultimately hinder the success of clinical trials, yet knowledge of species differences has yet to be systematically incorporated in the interpretation of animal models. Here we pr...
Gene ontology enrichment analysis of congenital diaphragmatic hernia-associated genes.
Pediatric research
Sep 25, 2018
Congenital diaphragmatic hernia (CDH) is a commonly occurring major congenital anomaly with a profound impact on neonatal mortality. The etiology of CDH is poorly understood and is complicated by multiple clinical presentations, reflecting the locati...
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