AIMC Topic: Signal Transduction

Clear Filters Showing 141 to 150 of 300 articles

Computational Approach to Investigating Key GO Terms and KEGG Pathways Associated with CNV.

BioMed research international Apr 11, 2018
Choroidal neovascularization (CNV) is a severe eye disease that leads to blindness, especially in the elderly population. Various endogenous and exogenous regulatory factors promote its pathogenesis. However, the detailed molecular biological mechani...
Humans Computational Biology Signal Transduction Neurons Gene Ontology Choroidal Neovascularization
View on PubMed DOI

Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical- Approach Combining Experiments and Machine Learning.

Frontiers in immunology Mar 20, 2018
Life-threatening cardiomyopathy is a severe, but common, complication associated with severe trauma or sepsis. Several signaling pathways involved in apoptosis and necroptosis are linked to trauma- or sepsis-associated cardiomyopathy. However, the un...
Cells, Cultured Animals Sepsis Mice Signal Transduction Humans Machine Learning Algorithms Receptor-Interacting Protein Serine-Threonine Kinases Cell Culture Techniques Apoptosis Necrosis Caspase 3 Cardiomyopathies Heparitin Sulfate Wounds and Injuries Myocytes, Cardiac Cytochromes c
View on PubMed DOI

Design and validation of an ontology-driven animal-free testing strategy for developmental neurotoxicity testing.

Toxicology and applied pharmacology Mar 13, 2018
Developmental neurotoxicity entails one of the most complex areas in toxicology. Animal studies provide only limited information as to human relevance. A multitude of alternative models have been developed over the years, providing insights into mech...
Humans Cells, Cultured Brain Reproducibility of Results Animals Models, Animal Toxicity Tests Risk Assessment Animal Testing Alternatives Signal Transduction Neurogenesis Neurons Neurotoxicity Syndromes Biological Ontologies Toxicology
View on PubMed DOI

Computational Strategies for Dissecting the High-Dimensional Complexity of Adaptive Immune Repertoires.

Frontiers in immunology Feb 21, 2018
The adaptive immune system recognizes antigens an immense array of antigen-binding antibodies and T-cell receptors, the immune repertoire. The interrogation of immune repertoires is of high relevance for understanding the adaptive immune response in...
Autoimmune Diseases High-Throughput Nucleotide Sequencing Receptors, Immunologic Adaptive Immunity Humans Machine Learning Software Animals Neoplasms HIV Infections Computational Biology Signal Transduction Data Interpretation, Statistical
View on PubMed DOI

Simvastatin and nanofibrous poly(l-lactic acid) scaffolds to promote the odontogenic potential of dental pulp cells in an inflammatory environment.

Acta biomaterialia Dec 30, 2017
UNLABELLED: In this study, we investigated the anti-inflammatory, odontogenic and pro-angiogenic effects of integrating simvastatin and nanofibrous poly(l-lactic acid) (NF-PLLA) scaffolds on dental pulp cells (DPCs). Highly porous NF-PLLA scaffolds t...
Cell Differentiation Human Umbilical Vein Endothelial Cells Alkaline Phosphatase Mesenchymal Stem Cells Humans Nanofibers Neovascularization, Physiologic Biomarkers Odontogenesis Polyesters Inflammation Young Adult Signal Transduction Gene Expression Regulation RNA, Messenger Lipopolysaccharides Tissue Scaffolds Dental Pulp Simvastatin Cytoprotection
View on PubMed DOI

The Interplay Between Epithelial-Mesenchymal Transition (EMT) and the Thyroid Hormones-αvβ3 Axis in Ovarian Cancer.

Hormones & cancer Dec 19, 2017
Ovarian cancer is a highly metastatic disease. The metastatic potential is enhanced by epithelial to mesenchymal transition (EMT) in which αvβ3 integrin plays a role. Thyroid hormones (L-thyroxine, T4, and 3,5,3'-triiodo-L-thyronine, T3) bind this in...
Humans Female Cell Line, Tumor Gene Expression Regulation, Neoplastic Signal Transduction Ovarian Neoplasms Zonula Occludens-1 Protein Epithelial-Mesenchymal Transition Thyroxine beta Catenin Cadherins Integrin alphaVbeta3 Thyroid Hormones Snail Family Transcription Factors Vimentin Zinc Finger E-box-Binding Homeobox 1 Triiodothyronine
View on PubMed DOI

Inhibitory activity of linarin on osteoclastogenesis through receptor activator of nuclear factor κB ligand-induced NF-κB pathway.

Biochemical and biophysical research communications Dec 18, 2017
Linarin, a natural flavonoid glycoside widely found in plants, has been reported to possess anti-inflammation, neuroprotection and osteogenic properties. However, its impact on osteoclast remains unclear. In the present study, the effects of linarin ...
Glycosides Dose-Response Relationship, Drug NF-kappa B Osteogenesis RAW 264.7 Cells Osteoblasts Mice Signal Transduction RANK Ligand Mice, Inbred C57BL Cells, Cultured Macrophages Animals
View on PubMed DOI

Multi-Objective Optimization Algorithm to Discover Condition-Specific Modules in Multiple Networks.

Molecules (Basel, Switzerland) Dec 14, 2017
The advances in biological technologies make it possible to generate data for multiple conditions simultaneously. Discovering the condition-specific modules in multiple networks has great merit in understanding the underlying molecular mechanisms of ...
Gene Expression Regulation Signal Transduction Cell Line Neoplasm Staging Models, Biological Humans Neural Networks, Computer Algorithms Biomarkers Breast Neoplasms Gene Expression Profiling Gene Regulatory Networks Computational Biology
View on PubMed DOI

Protective Effects of Garlic-Derived S-Allylmercaptocysteine on IL-1-Stimulated Chondrocytes by Regulation of MMPs/TIMP-1 Ratio and Type II Collagen Expression via Suppression of NF-B Pathway.

BioMed research international Dec 3, 2017
BACKGROUND: Garlic-derived S-allylmercaptocysteine (SAMC) has widely been used in many disease therapies. However, the potential effects and mechanism of SAMC on IL-1-stimulated chondrocytes are unclear.
Transcription Factor RelA Gene Expression Humans Cysteine NF-kappa B Tissue Inhibitor of Metalloproteinase-1 Garlic Chondrocytes Tumor Necrosis Factor-alpha Collagen Type II Osteoarthritis Signal Transduction Matrix Metalloproteinases Interleukin-1beta
View on PubMed DOI

From word models to executable models of signaling networks using automated assembly.

Molecular systems biology Nov 24, 2017
Word models (natural language descriptions of molecular mechanisms) are a common currency in spoken and written communication in biomedicine but are of limited use in predicting the behavior of complex biological networks. We present an approach to b...
Vemurafenib Enzyme Inhibitors Drug Resistance, Neoplasm Tumor Suppressor Protein p53 Proto-Oncogene Proteins p21(ras) Neural Networks, Computer Natural Language Processing Proto-Oncogene Proteins B-raf Computer Simulation DNA Damage Language Sulfonamides Melanoma Indoles Skin Neoplasms Humans Antineoplastic Agents Cell Line, Tumor Gene Expression Regulation, Neoplastic Models, Genetic Signal Transduction
View on PubMed DOI
Popular Topics
Recent Journals