Pulmonary hypertension (PH) is a progressive cardiopulmonary disorder. It features elevated pulmonary arterial pressure, which leads to right ventricular failure and increased mortality. PH's insidious nature, with no specific clinical symptoms, hind...
Acute myocardial infarction (AMI) stands as a major contributor to mortality and disability worldwide, with obesity playing a significant role in its development. This study aims to investigate potential biomarkers associated with obesity-related gen...
BACKGROUND: Periodontitis (PD) is a chronic, multifactorial inflammatory disorder characterized by the progressive destruction of periodontal tissues. Increasing evidence indicates that the dysregulation of hypoxia-related genes (HRGs) plays a pivota...
Proceedings of the National Academy of Sciences of the United States of America
Dec 26, 2025
Retinal ganglion cells (RGCs) transmit visual information from the eye to the brain. In mice, several RGC types show nonuniform spatial distributions, potentially mediating specific visual functions. However, the full extent of RGC specialization rem...
BACKGROUND: The development of spatial transcriptomics (ST) has enabled biologists to measure transcriptome data on an entire tissue and retain spatial information. It gives us the opportunity to fully understand the tissue microenvironment and ident...
Orthostatic hypotension is a sharp decrease in blood pressure when an individual transitions from a supine to an upright position. OH affects at least 30% of older adults. It is attributed to the dysfunction of the autonomic innervation and decreased...
Host-microbe interactions are increasingly recognized as an important module to understand disease progression and potential treatment strategies. Increasing evidence points to the microbiome's ability to modulate host gene expression, and thereby in...
Osteoarthritis (OA) is a chronic joint disorder characterized by cartilage degradation and accompanied by inflammatory processes. Inflammation and autophagy dysfunction have been associated with the pathogenesis of OA. However, the interplay between ...
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by amyloid-beta (Aβ) plaques and hyperphosphorylated tau pathology. Although palmitoylation has been implicated in AD, its specific mechanisms remain poorly defined. To ...
Type A aortic dissection (TAAD) is a vascular disease with high mortality; however, the role of gene methylation in its pathogenesis has received little attention. This study aimed to identify candidate markers of TAAD by integrating methylation and ...
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