AIMC Topic: Administration, Oral

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Pharmacokinetic and safety profile of tofacitinib in children with polyarticular course juvenile idiopathic arthritis: results of a phase 1, open-label, multicenter study.

Pediatric rheumatology online journal Dec 28, 2017
BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease and a leading cause of childhood disability. The objective of this study was to characterize the PK, safety, and taste acceptability of tofacitinib in pati...
Humans Female Male Pyrroles Adolescent Taste Arthritis, Juvenile Piperidines Protein Kinase Inhibitors Pyrimidines Child, Preschool Child Treatment Outcome Administration, Oral
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Quantification and pharmacokinetics of alpinetin in rat plasma by UHPLC-MS/MS using protein precipitation coupled with dilution approach to eliminate matrix effects.

Journal of pharmaceutical and biomedical analysis Dec 27, 2017
Alpinetin, a bioactive flavonoid, has attracted great attention due to its diverse therapeutic effects, namely anti-oxidant, anti-tumor and anti-inflammatory effects with low systemic toxicity. Various determination methods have been developed in qua...
Chromatography, High Pressure Liquid Tandem Mass Spectrometry Administration, Oral Flavanones Biological Availability Rats Rats, Sprague-Dawley Flavonoids Limit of Detection Plasma Reproducibility of Results Animals Male Plant Extracts
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Primary Care Provider Perceptions and Practices Regarding Dosing Units for Oral Liquid Medications.

Academic pediatrics Dec 18, 2017
INTRODUCTION: To prevent errors, health care professional and safety organizations recommend using milliliters (mL) alone for oral liquid medication dosing instructions and devices. In 2018, for federal incentives under the Quality Payment Program, o...
Internal Medicine Medication Errors Nurse Practitioners Pediatricians Physicians, Family Administration, Oral Physicians, Primary Care Drug Prescriptions Electronic Prescribing Humans Electronic Health Records Female Adult Male Middle Aged Surveys and Questionnaires Attitude of Health Personnel Pharmaceutical Preparations
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New, Immunomodulatory, Oral Nutrition Formula for Use Prior to Surgery in Patients With Head and Neck Cancer: An Exploratory Study.

JPEN. Journal of parenteral and enteral nutrition Dec 12, 2017
BACKGROUND: The perioperative use of immunomodulatory nutrition formulas in patients with head and neck cancer reduces the number of postoperative infections and the length of hospital stay.
Administration, Oral Immunomodulation Enteral Nutrition Preoperative Care Postoperative Complications Humans Length of Stay Female Treatment Outcome Male Head and Neck Neoplasms Middle Aged Single-Blind Method
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Deep Learning Based Regression and Multiclass Models for Acute Oral Toxicity Prediction with Automatic Chemical Feature Extraction.

Journal of chemical information and modeling Oct 27, 2017
Median lethal death, LD, is a general indicator of compound acute oral toxicity (AOT). Various in silico methods were developed for AOT prediction to reduce costs and time. In this study, we developed an improved molecular graph encoding convolutiona...
Administration, Oral Automation Toxicity Tests Lethal Dose 50 Informatics Machine Learning Models, Statistical Regression Analysis
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Pharmacokinetics, bioavailability, tissue distribution and excretion of tangeretin in rat.

Journal of food and drug analysis Sep 22, 2017
Tangeretin, 4',5,6,7,8-pentamethoxyflavone, is one of the major polymethoxyflavones (PMFs) existing in citrus fruits, particularly in the peels of sweet oranges and mandarins. Tangeretin has been reported to possess several beneficial bioactivities i...
Biological Availability Rats Animals Tissue Distribution Gastrointestinal Tract Rats, Sprague-Dawley Citrus Male Liver Flavones Fruit Feces Plant Extracts Administration, Oral
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Detection of lithospermate B in rat plasma at the nanogram level by LC/MS in multi reaction monitoring mode.

Journal of food and drug analysis Jul 8, 2017
Low bioavailability and high binding affinity to plasma proteins led to the difficulty for the quantitative detection of lithospermate B (LSB) in plasma. This study aimed to develop a protocol for detecting LSB in plasma. A method was employed to qua...
Mass Spectrometry Chromatography, Liquid Molecular Structure Drugs, Chinese Herbal Administration, Oral Biological Availability Reproducibility of Results Animals Male Protein Binding Rats
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Intravenous Chlorothiazide Versus Enteral Metolazone to Augment Loop Diuretic Therapy in the Intensive Care Unit.

The Annals of pharmacotherapy Dec 16, 2016
BACKGROUND: In cases of loop diuretic resistance in the intensive care unit (ICU), recommendations for a specific second-line thiazide agent are lacking.
Metolazone Sodium Potassium Chloride Symporter Inhibitors Diuresis Administration, Intravenous Chlorothiazide Furosemide Humans Retrospective Studies Critical Illness Intensive Care Units Female Adult Male Administration, Oral Drug Therapy, Combination
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Patient-level meta-analysis of efficacy and hypoglycaemia in people with type 2 diabetes initiating insulin glargine 100U/mL or neutral protamine Hagedorn insulin analysed according to concomitant oral antidiabetes therapy.

Diabetes research and clinical practice Nov 9, 2016
AIMS: Evaluate efficacy and hypoglycaemia according to concomitant oral antidiabetes drug (OAD) in people with type 2 diabetes initiating insulin glargine 100U/mL (Gla-100) or neutral protamine Hagedorn (NPH) insulin once daily.
Humans Female Male Glycated Hemoglobin Insulin Glargine Hypoglycemia Administration, Oral Drug Therapy, Combination Incidence Diabetes Mellitus, Type 2 Hypoglycemic Agents Treatment Outcome Randomized Controlled Trials as Topic Sulfonylurea Compounds Weight Gain Clinical Trials, Phase III as Topic Clinical Trials, Phase IV as Topic Insulin, Isophane
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Adaptations to excess choline in insulin resistant and Pcyt2 deficient skeletal muscle.

Biochemistry and cell biology = Biochimie et biologie cellulaire Sep 6, 2016
It was hypothesized that choline supplementation in insulin resistant (IR) CTP:phosphoethanolamine cytidylyltransferase deficient (Pcyt2) mice would ameliorate muscle function by remodeling glucose and fatty acid (FA) metabolism. Pcyt2 mice either re...
Carnitine O-Palmitoyltransferase Diacylglycerol O-Acyltransferase Insulin Receptor Substrate Proteins Organic Cation Transport Proteins RNA Nucleotidyltransferases Muscle, Skeletal Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Mice, Knockout Stearoyl-CoA Desaturase Animals Glucose Lipogenesis Mice Fatty Acids Adaptation, Physiological Insulin Resistance Administration, Oral Choline Signal Transduction Sterol Regulatory Element Binding Protein 1 Gene Expression Regulation PPAR alpha fas Receptor Triglycerides Microtubule-Associated Proteins
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