AIMC Topic: Administration, Oral

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Patient-level meta-analysis of efficacy and hypoglycaemia in people with type 2 diabetes initiating insulin glargine 100U/mL or neutral protamine Hagedorn insulin analysed according to concomitant oral antidiabetes therapy.

Diabetes research and clinical practice Nov 9, 2016
AIMS: Evaluate efficacy and hypoglycaemia according to concomitant oral antidiabetes drug (OAD) in people with type 2 diabetes initiating insulin glargine 100U/mL (Gla-100) or neutral protamine Hagedorn (NPH) insulin once daily.
Drug Therapy, Combination Weight Gain Clinical Trials, Phase III as Topic Humans Clinical Trials, Phase IV as Topic Female Insulin, Isophane Sulfonylurea Compounds Male Incidence Diabetes Mellitus, Type 2 Hypoglycemic Agents Treatment Outcome Randomized Controlled Trials as Topic Glycated Hemoglobin Insulin Glargine Hypoglycemia Administration, Oral
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Adaptations to excess choline in insulin resistant and Pcyt2 deficient skeletal muscle.

Biochemistry and cell biology = Biochimie et biologie cellulaire Sep 6, 2016
It was hypothesized that choline supplementation in insulin resistant (IR) CTP:phosphoethanolamine cytidylyltransferase deficient (Pcyt2) mice would ameliorate muscle function by remodeling glucose and fatty acid (FA) metabolism. Pcyt2 mice either re...
Animals Mice Insulin Resistance Signal Transduction Muscle, Skeletal Stearoyl-CoA Desaturase Lipogenesis Adaptation, Physiological Carnitine O-Palmitoyltransferase Diacylglycerol O-Acyltransferase Insulin Receptor Substrate Proteins Gene Expression Regulation Organic Cation Transport Proteins PPAR alpha RNA Nucleotidyltransferases Mice, Knockout Triglycerides Sterol Regulatory Element Binding Protein 1 Glucose Microtubule-Associated Proteins fas Receptor Fatty Acids Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Administration, Oral Choline
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Feed-forward neural network model for hunger and satiety related VAS score prediction.

Theoretical biology & medical modelling Jul 7, 2016
BACKGROUND: An artificial neural network approach was chosen to model the outcome of the complex signaling pathways in the gastro-intestinal tract and other peripheral organs that eventually produce the satiety feeling in the brain upon feeding.
Humans Peptide YY Ileum Satiation Visual Analog Scale Neural Networks, Computer Cholecystokinin Models, Biological Hunger Administration, Oral Databases as Topic Stomach
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Ombitasvir, paritaprevir, and ritonavir plus ribavirin for chronic hepatitis C virus genotype 4 infection in Egyptian patients with or without compensated cirrhosis (AGATE-II): a multicentre, phase 3, partly randomised open-label trial.

The lancet. Gastroenterology & hepatology Jun 16, 2016
BACKGROUND: In Egypt, chronic hepatitis C virus (HCV) infection occurs in around 10% of the population (about 8 million individuals), and is a leading cause of liver cirrhosis, hepatocellular carcinoma, and mortality. Although HCV genotype 4 constitu...
Carbamates Lactams, Macrocyclic Macrocyclic Compounds Ribavirin Genotype Sustained Virologic Response Liver Cirrhosis Drug Therapy, Combination Treatment Outcome Adult Hepatitis C, Chronic Follow-Up Studies Humans Male Valine Cyclopropanes Egypt Female Middle Aged Drug Administration Schedule Sulfonamides Aged Adolescent Anilides Hepacivirus Aged, 80 and over Antiviral Agents Administration, Oral Young Adult Proline Ritonavir
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On-line monitoring of in-vitro oral bioaccessibility tests as front-end to liquid chromatography for determination of chlorogenic acid isomers in dietary supplements.

Talanta Jan 1, 2016
A novel fully automated in-vitro oral dissolution test assay as a front-end to liquid chromatography has been developed and validated for on-line chemical profiling and monitoring of temporal release profiles of three caffeoylquinic acid (CQA) isomer...
Biological Availability Coffee Chlorogenic Acid Dietary Supplements Online Systems Chromatography, Liquid Limit of Detection Administration, Oral Isomerism
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A simple and sensitive UHPLC-MS/MS method for quantification of buddlejasaponin IV in rat plasma and its application to a pharmacokinetic study.

Journal of pharmaceutical and biomedical analysis Dec 29, 2015
Buddlejasaponin IV (BS-IV), a natural triterpene saponin isolated from several herbal plants, has drawn a lot of attention for its anti-inflammatory, antinociceptive, antihyperlipidemia, and antitumor activities. In this study, a simple and sensitive...
Chromatography, High Pressure Liquid Tandem Mass Spectrometry Administration, Oral Saponins Male Rats, Wistar Rats Dose-Response Relationship, Drug Triterpenes Animals
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The advantages of combination therapy on hypertension: development of immediate release perindopril-indapamide tablet and assessment of bioequivalence studies.

Pharmaceutical development and technology Oct 13, 2015
Hypertension has a major associated risk for organ damage and mortality, which is further heightened in patients with prior cardiovascular events, comorbid diabetes mellitus, microalbuminuria and renal impairment. Convers Plus tablet including perind...
Drug Combinations Area Under Curve Tablets Young Adult Administration, Oral Humans Adult Cross-Over Studies Angiotensin-Converting Enzyme Inhibitors Male Middle Aged Chemistry, Pharmaceutical Hypertension Therapeutic Equivalency Indapamide Perindopril
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Pharmacokinetic comparison of different flubendazole formulations in pigs: A further contribution to its development as a macrofilaricide molecule.

International journal for parasitology. Drugs and drug resistance Sep 25, 2015
Despite the well established ivermectin activity against microfilaria, the success of human filariasis control programmes requires the use of a macrofilaricide compound. Different in vivo trials suggest that flubendazole (FLBZ), an anthelmintic benzi...
Swine Injections, Subcutaneous Carboxymethylcellulose Sodium Administration, Oral Cross-Over Studies Anthelmintics Animals Mebendazole Dosage Forms 2-Hydroxypropyl-beta-cyclodextrin Polysorbates
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Population pharmacokinetic/pharmacodynamic assessment of pharmacological effect of a selective estrogen receptor β agonist on total testosterone in healthy men.

Clinical pharmacology in drug development Jun 8, 2015
BACKGROUND: LY500307 is a highly selective estrogen receptor β (ERβ) agonist, which loses its selectivity at high dose and leads to undesirable suppression of total testosterone (TT) concentration. The objective of the present analysis was to define ...
Cross-Over Studies Healthy Volunteers Nonlinear Dynamics Benzopyrans Drug Administration Schedule Estrogen Receptor beta Testosterone Fourier Analysis Single-Blind Method London Models, Biological Selective Estrogen Receptor Modulators Humans Biomarkers Circadian Rhythm Young Adult Administration, Oral Adult Male Middle Aged
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Absolute oral bioavailability and pharmacokinetics of canagliflozin: A microdose study in healthy participants.

Clinical pharmacology in drug development Dec 11, 2014
Absolute oral bioavailability of canagliflozin was assessed by simultaneous oral administration with intravenous [(14) C]-canagliflozin microdose infusion in nine healthy men. Pharmacokinetics of canagliflozin, [(14) C]-canagliflozin, and total radio...
Hypoglycemic Agents Infusions, Intravenous Area Under Curve Models, Biological Administration, Oral Adult Male Middle Aged Adolescent Feces Biological Availability Healthy Volunteers Canagliflozin Hepatobiliary Elimination Humans Young Adult
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