The combination of chemotherapy can enhance the efficacy of immune checkpoint inhibitors (ICIs), but requires precise patient stratification and biomarker screening. Cytokines influence immunotherapy outcomes, and multiplex cytokine profiling aids in...
AIM: Parkinson's disease (PD) and progressive supranuclear palsy (PSP) present similar clinical symptoms, but their treatment options and clinical prognosis differ significantly. Therefore, we aimed to discriminate between PD and PSP based on multi-l...
BACKGROUND: Ambient fine particulate matter (PM) is a significant global public health concern. However, large-scale research has yet to explore the effects of long-term PM exposure on the pulmonary nodule characteristics.
Ecotoxicology and environmental safety
Jul 21, 2025
OBJECTIVE: Evidence from prior studies indicates that certain endocrine-disrupting chemicals (EDCs), such as phenols and phthalates, may serve as environmental risk factors for chronic obstructive pulmonary disease (COPD). However, no studies have ex...
BACKGROUND: Racially minoritized populations in the United States (US), notably African American (AA) and American Indian/Alaska Native (AI/AN), experience disproportionately higher rates of chronic kidney disease (CKD), diabetes, and hypertension co...
BMC medical informatics and decision making
Jul 21, 2025
BACKGROUND: Nosocomial infections are a major cause of morbidity and mortality in the ICU. Earlier identification of these complications may facilitate better clinical management and improve outcomes. We developed a dynamic prediction model that leve...
OBJECTIVE: To construct an artificial intelligence (AI)-assisted model for identifying the infraorbital posterior ethmoid cells (IPECs) based on deep learning using sagittal CT images.
The specific role of lysophospholipids (LysoPLs) in the pathogenesis of chronic obstructive pulmonary disease (COPD) is not yet fully understood. We determined serum LysoPLs in 20 patients with stable COPD and 20 healthy smokers using liquid chromato...
Rheumatoid arthritis (RA) is a systemic inflammatory condition posing challenges in identifying biomarkers for onset, severity and treatment responses. Here we investigate the plasma proteome in a longitudinal cohort of 278 RA patients, alongside 60 ...
BACKGROUND: Detecting malignant transformation of sinonasal inverted papilloma (SIP) into squamous cell carcinoma (SIP-SCC) before surgery is a clinical need. We aimed to explore the value of deep learning (DL) that leverages nasal endoscopy and T2-w...
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