AIMC Topic: Angiogenesis Inhibitors

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A semi-automated machine-learning based workflow for ellipsoid zone analysis in eyes with macular edema: SCORE2 pilot study.

PloS one Apr 30, 2020
BACKGROUND AND OBJECTIVE: To develop a semi-automated, machine-learning based workflow to evaluate the ellipsoid zone (EZ) assessed by spectral domain optical coherence tomography (SD-OCT) in eyes with macular edema secondary to central retinal or he...
Middle Aged Pilot Projects Image Processing, Computer-Assisted Angiogenesis Inhibitors Treatment Outcome Humans Machine Learning Female Adult Male Recombinant Fusion Proteins Macula Lutea Receptors, Vascular Endothelial Growth Factor Bevacizumab Retinal Vein Occlusion Tomography, Optical Coherence Drug Monitoring Workflow Macular Edema Vascular Endothelial Growth Factor A
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Prediction of visual outcomes by an artificial neural network following intravitreal injection and laser therapy for retinopathy of prematurity.

The British journal of ophthalmology Nov 19, 2019
AIMS: To construct a program to predict the visual acuity (VA), best corrected VA (BCVA) and spherical equivalent (SE) of patients with retinopathy of prematurity (ROP) from 3 to 12 years old after intravitreal injection (IVI) of anti-vascular endoth...
Child Intravitreal Injections Retrospective Studies Humans Angiogenesis Inhibitors Ranibizumab Female Neural Networks, Computer Retinopathy of Prematurity Visual Acuity Male Bevacizumab Predictive Value of Tests Refraction, Ocular Laser Coagulation Vascular Endothelial Growth Factor A Child, Preschool
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[Chances of Artificial Intelligence and Big Data for the Diagnosis and Treatment of Age-related Macular Degeneration].

Klinische Monatsblatter fur Augenheilkunde Oct 31, 2019
Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) is an effective therapy of the neovascular form of this condition. Multimodal...
Artificial Intelligence Big Data Angiogenesis Inhibitors Vascular Endothelial Growth Factor A Macular Degeneration Humans Intravitreal Injections Ranibizumab Choroidal Neovascularization
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Automated diagnosis and quantitative analysis of plus disease in retinopathy of prematurity based on deep convolutional neural networks.

Acta ophthalmologica Sep 27, 2019
BACKGROUND: The purpose of this study was to develop an automated diagnosis and quantitative analysis system for plus disease. The system provides a diagnostic decision but also performs quantitative analysis of the typical pathological features of t...
ROC Curve Angiogenesis Inhibitors Image Interpretation, Computer-Assisted Infant, Premature Intravitreal Injections Humans Infant, Newborn Diagnosis, Computer-Assisted Deep Learning Ranibizumab Retinopathy of Prematurity Retinal Vessels Infant, Extremely Low Birth Weight
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Reinforcement learning-based control of tumor growth under anti-angiogenic therapy.

Computer methods and programs in biomedicine Mar 8, 2019
BACKGROUND AND OBJECTIVES: In recent decades, cancer has become one of the most fatal and destructive diseases which is threatening humans life. Accordingly, different types of cancer treatment are studied with the main aim to have the best treatment...
Blood Vessels Neoplasms Time Factors Immunotherapy Angiogenesis Inhibitors Models, Statistical Probability Markov Chains Neovascularization, Pathologic Medical Informatics Endothelial Cells Humans Machine Learning Algorithms Computer Simulation
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Predicting Visual Acuity by Using Machine Learning in Patients Treated for Neovascular Age-Related Macular Degeneration.

Ophthalmology Feb 14, 2018
PURPOSE: To predict, by using machine learning, visual acuity (VA) at 3 and 12 months in patients with neovascular age-related macular degeneration (AMD) after initial upload of 3 anti-vascular endothelial growth factor (VEGF) injections.
Choroidal Neovascularization Visual Acuity Vascular Endothelial Growth Factor A Intravitreal Injections Databases, Factual Wet Macular Degeneration Female Humans Male Reproducibility of Results Machine Learning Middle Aged Aged Algorithms Disease Progression Aged, 80 and over Angiogenesis Inhibitors Follow-Up Studies
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Changes in systemic vascular endothelial growth factor levels after intravitreal injection of aflibercept in infants with retinopathy of prematurity.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie Dec 30, 2017
BACKGROUND: To investigate the levels of VEGF in the systemic circulation of patients with type 1 ROP who received intravitreal injections of 1 mg (0.025 mL) aflibercept (IVA) or 0.625 mg (0.025 mL) bevacizumab (IVB).
Vascular Endothelial Growth Factors Intravitreal Injections Recombinant Fusion Proteins Receptors, Vascular Endothelial Growth Factor Retinopathy of Prematurity Enzyme-Linked Immunosorbent Assay Angiogenesis Inhibitors Treatment Outcome Follow-Up Studies Dose-Response Relationship, Drug Prognosis Female Humans Infant, Newborn Prospective Studies Male Biomarkers Time Factors
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The Effect of Lenalidomide on Health-Related Quality of Life in Patients With Lower-Risk Non-del(5q) Myelodysplastic Syndromes: Results From the MDS-005 Study.

Clinical lymphoma, myeloma & leukemia Dec 30, 2017
BACKGROUND: The phase III MDS-005 study compared lenalidomide versus placebo in red blood cell transfusion-dependent (RBC-TD) patients with lower-risk non-del(5q) myelodysplastic syndromes (MDS), ineligible/refractory to erythropoiesis-stimulating ag...
Chromosome Deletion Disease Progression Aged, 80 and over Chromosomes, Human, Pair 5 Humans Adult Lenalidomide Surveys and Questionnaires Female Male Myelodysplastic Syndromes Angiogenesis Inhibitors Risk Factors Middle Aged Double-Blind Method Aged Quality of Life Outcome Assessment, Health Care
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Evaluating the impact of vitreomacular adhesion on anti-VEGF therapy for retinal vein occlusion using machine learning.

Scientific reports Jun 7, 2017
Vitreomacular adhesion (VMA) represents a prognostic biomarker in the management of exudative macular disease using anti-vascular endothelial growth factor (VEGF) agents. However, manual evaluation of VMA in 3D optical coherence tomography (OCT) is l...
Humans Machine Learning Female Male Angiogenesis Inhibitors Macula Lutea Treatment Outcome Visual Acuity Tomography, Optical Coherence Retinal Vein Occlusion Tissue Adhesions Vascular Endothelial Growth Factor A
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Machine Learning to Analyze the Prognostic Value of Current Imaging Biomarkers in Neovascular Age-Related Macular Degeneration.

Ophthalmology. Retina May 31, 2017
PURPOSE: To evaluate the potential of machine learning to predict best-corrected visual acuity (BCVA) outcomes from structural and functional assessments during the initiation phase in patients receiving standardized ranibizumab therapy for neovascul...
Treatment Outcome Follow-Up Studies Visual Acuity Retinal Pigment Epithelium Tomography, Optical Coherence Vascular Endothelial Growth Factor A Machine Learning Wet Macular Degeneration Humans Fundus Oculi Intravitreal Injections Prospective Studies Fluorescein Angiography Prognosis Macula Lutea Reproducibility of Results Ranibizumab Angiogenesis Inhibitors
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