AIMC Topic: Angiogenesis Inhibitors

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Myricitrin inhibits vascular endothelial growth factor-induced angiogenesis of human umbilical vein endothelial cells and mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Sep 17, 2020
In the present study, the protective effects of myricitrin against vascular endothelial growth factor (VEGF)-induced angiogenesis of vascular endothelial cells were characterized. Cells were induced with 50 ng/mL VEGF in the presence or absence of va...
Angiogenesis Inhibitors Xenograft Model Antitumor Assays Humans Caspases Biomarkers Disease Models, Animal Matrix Metalloproteinases Animals Apoptosis Neovascularization, Pathologic Cell Line, Tumor Flavonoids Neovascularization, Physiologic Mice Human Umbilical Vein Endothelial Cells Vascular Endothelial Growth Factors
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Prediction of response to anti-vascular endothelial growth factor treatment in diabetic macular oedema using an optical coherence tomography-based machine learning method.

Acta ophthalmologica Jun 22, 2020
PURPOSE: To predict the anti-vascular endothelial growth factor (VEGF) therapeutic response of diabetic macular oedema (DME) patients from optical coherence tomography (OCT) at the initiation stage of treatment using a machine learning-based self-exp...
Machine Learning Algorithms Prognosis Retrospective Studies Follow-Up Studies Macular Edema Female Humans Visual Acuity Vascular Endothelial Growth Factor A Aged Diabetic Retinopathy Tomography, Optical Coherence Intravitreal Injections Male Middle Aged ROC Curve Angiogenesis Inhibitors
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A semi-automated machine-learning based workflow for ellipsoid zone analysis in eyes with macular edema: SCORE2 pilot study.

PloS one Apr 30, 2020
BACKGROUND AND OBJECTIVE: To develop a semi-automated, machine-learning based workflow to evaluate the ellipsoid zone (EZ) assessed by spectral domain optical coherence tomography (SD-OCT) in eyes with macular edema secondary to central retinal or he...
Receptors, Vascular Endothelial Growth Factor Bevacizumab Retinal Vein Occlusion Image Processing, Computer-Assisted Angiogenesis Inhibitors Female Treatment Outcome Workflow Adult Tomography, Optical Coherence Macular Edema Drug Monitoring Humans Male Vascular Endothelial Growth Factor A Machine Learning Recombinant Fusion Proteins Middle Aged Macula Lutea Pilot Projects
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Prediction of visual outcomes by an artificial neural network following intravitreal injection and laser therapy for retinopathy of prematurity.

The British journal of ophthalmology Nov 19, 2019
AIMS: To construct a program to predict the visual acuity (VA), best corrected VA (BCVA) and spherical equivalent (SE) of patients with retinopathy of prematurity (ROP) from 3 to 12 years old after intravitreal injection (IVI) of anti-vascular endoth...
Humans Neural Networks, Computer Retrospective Studies Female Visual Acuity Predictive Value of Tests Vascular Endothelial Growth Factor A Intravitreal Injections Ranibizumab Male Refraction, Ocular Child, Preschool Child Angiogenesis Inhibitors Retinopathy of Prematurity Bevacizumab Laser Coagulation
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[Chances of Artificial Intelligence and Big Data for the Diagnosis and Treatment of Age-related Macular Degeneration].

Klinische Monatsblatter fur Augenheilkunde Oct 31, 2019
Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) is an effective therapy of the neovascular form of this condition. Multimodal...
Choroidal Neovascularization Angiogenesis Inhibitors Vascular Endothelial Growth Factor A Macular Degeneration Intravitreal Injections Ranibizumab Humans Artificial Intelligence Big Data
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Automated diagnosis and quantitative analysis of plus disease in retinopathy of prematurity based on deep convolutional neural networks.

Acta ophthalmologica Sep 27, 2019
BACKGROUND: The purpose of this study was to develop an automated diagnosis and quantitative analysis system for plus disease. The system provides a diagnostic decision but also performs quantitative analysis of the typical pathological features of t...
Image Interpretation, Computer-Assisted Infant, Premature Intravitreal Injections Ranibizumab Retinopathy of Prematurity Retinal Vessels Infant, Extremely Low Birth Weight Infant, Newborn Diagnosis, Computer-Assisted Deep Learning ROC Curve Humans Angiogenesis Inhibitors
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Reinforcement learning-based control of tumor growth under anti-angiogenic therapy.

Computer methods and programs in biomedicine Mar 8, 2019
BACKGROUND AND OBJECTIVES: In recent decades, cancer has become one of the most fatal and destructive diseases which is threatening humans life. Accordingly, different types of cancer treatment are studied with the main aim to have the best treatment...
Neovascularization, Pathologic Medical Informatics Endothelial Cells Blood Vessels Humans Machine Learning Models, Statistical Algorithms Time Factors Probability Computer Simulation Markov Chains Immunotherapy Neoplasms Angiogenesis Inhibitors
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Predicting Visual Acuity by Using Machine Learning in Patients Treated for Neovascular Age-Related Macular Degeneration.

Ophthalmology Feb 14, 2018
PURPOSE: To predict, by using machine learning, visual acuity (VA) at 3 and 12 months in patients with neovascular age-related macular degeneration (AMD) after initial upload of 3 anti-vascular endothelial growth factor (VEGF) injections.
Humans Machine Learning Algorithms Databases, Factual Female Reproducibility of Results Aged Aged, 80 and over Visual Acuity Male Vascular Endothelial Growth Factor A Middle Aged Intravitreal Injections Disease Progression Wet Macular Degeneration Angiogenesis Inhibitors Choroidal Neovascularization Follow-Up Studies
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Changes in systemic vascular endothelial growth factor levels after intravitreal injection of aflibercept in infants with retinopathy of prematurity.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie Dec 30, 2017
BACKGROUND: To investigate the levels of VEGF in the systemic circulation of patients with type 1 ROP who received intravitreal injections of 1 mg (0.025 mL) aflibercept (IVA) or 0.625 mg (0.025 mL) bevacizumab (IVB).
Receptors, Vascular Endothelial Growth Factor Retinopathy of Prematurity Follow-Up Studies Dose-Response Relationship, Drug Vascular Endothelial Growth Factors Intravitreal Injections Recombinant Fusion Proteins Male Time Factors Enzyme-Linked Immunosorbent Assay Angiogenesis Inhibitors Treatment Outcome Prospective Studies Biomarkers Humans Prognosis Female Infant, Newborn
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The Effect of Lenalidomide on Health-Related Quality of Life in Patients With Lower-Risk Non-del(5q) Myelodysplastic Syndromes: Results From the MDS-005 Study.

Clinical lymphoma, myeloma & leukemia Dec 30, 2017
BACKGROUND: The phase III MDS-005 study compared lenalidomide versus placebo in red blood cell transfusion-dependent (RBC-TD) patients with lower-risk non-del(5q) myelodysplastic syndromes (MDS), ineligible/refractory to erythropoiesis-stimulating ag...
Disease Progression Surveys and Questionnaires Angiogenesis Inhibitors Chromosome Deletion Aged, 80 and over Double-Blind Method Chromosomes, Human, Pair 5 Humans Adult Lenalidomide Outcome Assessment, Health Care Female Male Myelodysplastic Syndromes Risk Factors Middle Aged Aged Quality of Life
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