AIMC Topic: Animals

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Self-Driving and Detachable Lab-Microrobots Tailor Drug Delivery for Closed-Loop Stimulation of the Antitumor Immune Cycle.

ACS nano
Hypoxia arises in most solid tumors with insufficient blood flow, which hinders the delivery and efficacy of therapeutic agents to tumors. In this work, utilizing anaerobic bacteria capable of seeking out hypoxic areas for flourishing, we constructed...

Magnetic-Driven Hydrogel Robots Loaded with Mitomycin for Active Therapy of Bladder Cancer.

ACS applied materials & interfaces
Intravesical drug instillation is a common treatment for bladder cancer, but it suffers from poor targeting and suboptimal patient experience due to the influence of gravity. Here, we innovatively designed a bladder cancer treatment method using sodi...

Predictive learning rules generate a cortical-like replay of probabilistic sensory experiences.

eLife
The brain is thought to construct an optimal internal model representing the probabilistic structure of the environment accurately. Evidence suggests that spontaneous brain activity gives such a model by cycling through activity patterns evoked by pr...

Engineered multi-domain lipid nanoparticles for targeted delivery.

Chemical Society reviews
Engineered lipid nanoparticles (LNPs) represent a breakthrough in targeted drug delivery, enabling precise spatiotemporal control essential to treat complex diseases such as cancer and genetic disorders. However, the complexity of the delivery proces...

High-Sensitivity Detection of C-Peptide Biomarker for Diabetes by Solid-State Nanopore Using Machine Learning Identification.

The journal of physical chemistry letters
Accurate and early detection of C-peptide, a stable biomarker indicative of diabetes, is crucial for disease diagnosis, treatment, and prevention. This study explores a novel detection methodology using solid-state nanopore technology coupled with ma...

From neurotoxicity to neuroprotection: Rethinking GABAR-targeting anesthetics.

Cell biology and toxicology
The brain growth spurt (BGS) represents a pivotal window in neurodevelopment, defined by rapid neurogenesis, heightened synaptogenesis, and the dynamic establishment of neural networks. During this phase, heightened brain plasticity significantly enh...

Bio-Inspired spiking tactile sensing system for robust texture recognition across varying scanning speeds in passive touch.

Biological cybernetics
Tactile sensing plays a crucial role in texture recognition, but variations in scanning speed pose a significant challenge for accurate discrimination. Previous studies have demonstrated that scanning speed alters the frequency of texture-induced vib...

Automated analysis of mouse rearing using deep learning.

Journal of pharmacological sciences
Rodent rearing behavior is frequently assessed as an indicator of anxiety and exploratory tendencies. This study developed a convolutional recurrent neural network (CRNN) model to detect mouse rearing using overhead videos. Behavioral data from C57BL...

Mucosal immune responses and intestinal microbiome associations in wild spotted hyenas (Crocuta crocuta).

Communications biology
Little is known about host-gut microbiome interactions within natural populations at the intestinal mucosa, the primary interface. We investigate associations between the intestinal microbiome and mucosal immune measures while controlling for host, s...

Optimal feature selection and model explanation for reef fish sound classification.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Fish produce a wide variety of sounds that contribute to the soundscapes of aquatic environments. In reef systems, these sounds are important acoustic cues for various ecological processes. Artificial intelligence methods to detect, classify and iden...