Diabetes is a complex metabolic disorder, and its pathogenesis involves the interplay of genetic, environmental factors, and lifestyle choices. With the rising prevalence and increasing associated chronic complications, identifying and understanding ...
Sarcopenia, characterized by progressive loss of muscle mass and function, is a growing public health concern. The ZJU index, a novel metabolic marker, integrates lipid metabolism and glucose regulation parameters. While its association with metaboli...
The lancet. Gastroenterology & hepatology
Jul 1, 2025
BACKGROUND: Biological therapeutics are widely used in Crohn's disease, with evidence of efficacy from randomised trials and real-world experience. Primary non-response is a common, poorly understood problem. We aimed to assess blood methylation as a...
Transplant medicine faces substantial challenges, as patients require lifelong immunosuppression to prevent graft rejection. Immunosuppressive regimens to date, while reasonably effective at preventing acute rejection, cause numerous health complicat...
BACKGROUND: Mild to moderate depression (MMD), as an early stage of depression, has a high incidence and may progress to severe depression, even leading to suicide. The lack of effective screening and treatment is due to the unknown metabolic changes...
Protein lactylation, a novel post-translational modification (PTM), has emerged as a critical factor in disease processes related to glycolysis and immune responses. However, its role in aortic dissection (AD) has yet to be thoroughly investigated. T...
Metabolic Syndrome (MetS) comprises a clustering of conditions that significantly increase the risk of heart disease, stroke, and diabetes. Timely detection and intervention are crucial in preventing severe health outcomes. In this study, we implemen...
The preferred treatment for acute ischaemic stroke (AIS) is intravenous thrombolysis (IVT) administered within 4.5 hours (h) of symptom onset. This study aimed to identify metabolomic biomarkers for distinguishing AIS patients within 4.5 h of symptom...
Extracellular vesicles (EVs) in plasma are composed of exosomes, microvesicles, and apoptotic bodies. We report a plasma EV enrichment strategy using magnetic beads called Mag-Net. Proteomic interrogation of this plasma EV fraction enables the detect...
Plasma proteomics provides a unique opportunity to enhance disease prediction by capturing protein expression patterns linked to diverse pathological processes. Leveraging data from 2,923 proteins measured in 53,030 UK Biobank participants, we develo...
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