AIMC Topic: Cell Line, Tumor
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A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells.
Scientific reports
Feb 28, 2018
AMPK is a serine threonine kinase composed of a heterotrimer of a catalytic, kinase-containing α and regulatory β and γ subunits. Here we show that individual AMPK subunit expression and requirement for survival varies across colon cancer cell lines....
Support vector machine classifier for prediction of the metastasis of colorectal cancer.
International journal of molecular medicine
Jan 2, 2018
Colorectal cancer (CRC) is one of the most common cancers and a major cause of mortality. The present study aimed to identify potential biomarkers for CRC metastasis and uncover the mechanisms underlying the etiology of the disease. The five datasets...
Quantitative assessment of cancer cell morphology and motility using telecentric digital holographic microscopy and machine learning.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Dec 28, 2017
The noninvasive, fast acquisition of quantitative phase maps using digital holographic microscopy (DHM) allows tracking of rapid cellular motility on transparent substrates. On two-dimensional surfaces in vitro, MDA-MB-231 cancer cells assume several...
Chemical findings and in vitro biological studies to uphold the use of Ficus exasperata Vahl leaf and stem bark.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Dec 27, 2017
Ficus exasperata Vahl, commonly known as sandpaper, is a terrestrial Afro-tropical tree used in popular medicine. Despite the existence of some works on the biological activities of this species, its chemical composition is still poorly known. The ai...
Superoxides
Plant Leaves
Spectrometry, Mass, Electrospray Ionization
Nitric Oxide
Ficus
Humans
Drug Screening Assays, Antitumor
Plant Stems
Spectrophotometry, Ultraviolet
Hypoglycemic Agents
Reproducibility of Results
Plant Bark
Inhibitory Concentration 50
Functional Food
Cell Line, Tumor
Dose-Response Relationship, Drug
Free Radical Scavengers
Chromatography, High Pressure Liquid
Plant Extracts
Dietary Supplements
Peanut testa extracts possessing histone deacetylase inhibitory activity induce apoptosis in cholangiocarcinoma cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Dec 27, 2017
Previous studies demonstrated that peanut testa extracts (KK4 and ICG15042) containing natural histone deacetylase (HDAC) inhibitors inhibited the growth of several human cancer cell lines via apoptosis induction. The aims of this study were to inves...
Chemical characterization, antioxidant, genotoxic and in vitro cytotoxic activity assessment of Juniperus communis var. saxatilis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Dec 26, 2017
Chemical composition and antioxidative, genotoxic and cytotoxic potential of essential oil (EO) and post-distillation waste (PDW) of Serbian Juniperus communis L. var. saxatilis Pall. was studied in human lung carcinoma (A549) and normal lung fibrobl...
Humans
Mutagens
Female
Cell Division
Animals
G2 Phase
Male
Juniperus
Drug Screening Assays, Antitumor
Tandem Mass Spectrometry
Apoptosis
Gas Chromatography-Mass Spectrometry
Cell Line
Doxorubicin
Antineoplastic Agents, Phytogenic
Cell Line, Tumor
Chromatography, Liquid
Antioxidants
Plant Extracts
Rats
Gas chromatography-mass spectrometry metabolomic study of lipopolysaccharides toxicity on rat basophilic leukemia cells.
Chemico-biological interactions
Dec 22, 2017
Lipopolysaccharide (LPS) can lead to uncontrollable cytokine production, fatal sepsis syndrome and depression/multiple organ failure, as pathophysiologic demonstration. Various toxic effects of LPS have been extensively reported, mainly on the toxici...
Aggregation-Induced Emission Probe for Specific Turn-On Quantification of Soluble Transferrin Receptor: An Important Disease Marker for Iron Deficiency Anemia and Kidney Diseases.
Analytical chemistry
Dec 22, 2017
Transferrin receptor (TfR) is overexpressed on the surface of many cancer cells due to its vital roles in iron circulation and cellular respiration. Soluble transferrin receptor (sTfR), a truncated extracellular form of TfR in serum, is an important ...
Human Wharton's Jelly-Derived Stem Cells Display a Distinct Immunomodulatory and Proregenerative Transcriptional Signature Compared to Bone Marrow-Derived Stem Cells.
Stem cells and development
Dec 21, 2017
Mesenchymal stromal cells (MSCs) are multipotent stem cells with immunosuppressive and trophic support functions. While MSCs from different sources frequently display a similar appearance in culture, they often show differences in their surface marke...
Cytotoxicity of the Defensive Secretion from the Medicinal Insect Blaps rynchopetera.
Molecules (Basel, Switzerland)
Dec 21, 2017
Fairmaire has long been used as a folk medicine by the Yi and Bai ethnic groups in China to treat fever, cough, gastritis, boils, and tumors. In the present study, the cytotoxicity of the defensive secretion (TDS) of against AGS Caco-2, HepG2 U251 ...
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