AIMC Topic: Cell Movement

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G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation.

Journal of vascular research Apr 12, 2016
Vascular smooth muscle cell (VSMC) migration and proliferation is central to neointima formation in vein graft failure following coronary artery bypass. However, there are currently no pharmacological interventions that prevent vein graft failure thr...
Naphthols Purinones Saphenous Vein Time Factors Myocytes, Smooth Muscle Cell Proliferation Endothelial Cells Muscle, Smooth, Vascular Signal Transduction Actin Cytoskeleton Thiazolidines Dose-Response Relationship, Drug Cell Movement Aminosalicylic Acids Hydrazones Receptors, G-Protein-Coupled Thiourea Humans rho-Associated Kinases HEK293 Cells rhoA GTP-Binding Protein
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In-Vivo Imaging of Cell Migration Using Contrast Enhanced MRI and SVM Based Post-Processing.

PloS one Dec 14, 2015
The migration of cells within a living organism can be observed with magnetic resonance imaging (MRI) in combination with iron oxide nanoparticles as an intracellular contrast agent. This method, however, suffers from low sensitivity and specificty. ...
Humans Cell Line, Tumor Support Vector Machine Contrast Media Magnetic Resonance Imaging Cell Movement
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Modulatory role of garlicin in migration and invasion of intrahepatic cholangiocarcinoma via PI3K/AKT pathway.

International journal of clinical and experimental pathology Nov 1, 2015
Increasing evidences have indicated the role of garlicin in inhibiting the progression of various tumors including glioma, pulmonary carcinoma and pancreatic carcinoma, via mediating cell apoptosis or cell cycle. The regulatory effect and related mol...
Cell Line, Tumor Cell Proliferation Signal Transduction Cell Movement Neoplasm Invasiveness Dose-Response Relationship, Drug Antineoplastic Agents, Phytogenic Phosphorylation Humans Protein Kinase Inhibitors Cholangiocarcinoma Proto-Oncogene Proteins c-akt Phosphatidylinositol 3-Kinase Bile Duct Neoplasms Phosphoinositide-3 Kinase Inhibitors Disulfides Allyl Compounds
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Effects of xenoestrogens in human M1 and M2 macrophage migration, cytokine release, and estrogen-related signaling pathways.

Environmental toxicology May 26, 2015
Bisphenol A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and di(n-butyl)phthalate (DBP) are environmental estrogens that have been associated with a wide range of adverse health outcomes for which inflammation has also been hypothesized as a potentially ...
Cell Migration Assays, Macrophage Inflammation Chemotaxis, Leukocyte Diethylhexyl Phthalate Signal Transduction Cytokines Cell Movement Humans Female Lipopolysaccharides Phenols Tumor Necrosis Factor-alpha Middle Aged Cells, Cultured Estradiol Interleukin-1beta Macrophages NF-kappa B Benzhydryl Compounds
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Simulation of a Free Boundary Cell Migration Model through Physics Informed Neural Networks.

Journal of the mechanical behavior of biomedical materials Jul 1, 2025
Understanding the complexities of single-cell migration is facilitated by computational modeling, which provides important insights into the physiological processes that underlie migration mechanisms. This study developed a computational model for on...
Neural Networks, Computer Biomechanical Phenomena Cell Movement Models, Biological Actins Mechanical Phenomena Actomyosin
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Machine learning identifies SRD5A3 as a propionate-related prognostic biomarker in triple-negative breast cancer.

Scientific reports May 29, 2025
The increased risk of recurrence and metastasis are obstacles to treating TNBC. Propionate-related genes play an important role in tumor development and immune cell infiltration. The study was to identify the association between propionate-related ge...
Humans Machine Learning Prognosis Female Biomarkers, Tumor Membrane Proteins Cell Proliferation Gene Expression Profiling Triple Negative Breast Neoplasms Cell Movement Cell Line, Tumor Gene Expression Regulation, Neoplastic Propionates
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Effect of Cell-Cell Interaction on Single-Cell Behavior Revealed by a Deep Learning-Aided High-Throughput Addressable Single-Cell Coculture System.

Analytical chemistry May 13, 2025
Cell-cell interactions are crucial for understanding various physiological and pathological processes, yet conventional population-level methods fail to disclose the heterogeneity at a single-cell resolution. Single-cell coculture systems that isolat...
Human Umbilical Vein Endothelial Cells Cell Communication High-Throughput Screening Assays Coculture Techniques Humans Single-Cell Analysis Cell Proliferation Deep Learning Cell Movement Cell Line, Tumor
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Development of a prognostic model for osteosarcoma based on macrophage polarization-related genes using machine learning: implications for personalized therapy.

Clinical and experimental medicine May 9, 2025
While neoadjuvant chemotherapy combined with surgical resection has improved the prognosis for patients with osteosarcoma, its impact on metastatic and recurrent cases remains limited. Immunotherapy is emerging as a promising alternative. However, th...
Osteosarcoma Bone Neoplasms Humans Tumor-Associated Macrophages Machine Learning Macrophage Activation Macrophages Gene Expression Regulation, Neoplastic Precision Medicine Prognosis Membrane Proteins Female Cell Proliferation Cell Movement Male Gene Expression Profiling Cell Line, Tumor
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A quantitative characterization of the heterogeneous response of glioblastoma U-87 MG cell line to temozolomide.

Scientific reports May 8, 2025
Most cancers are genetically and phenotypically heterogeneous. This includes subpopulations of cells with different levels of sensitivity to chemotherapy, which may lead to treatment failure as the more resistant cells can survive drug treatment and ...
Temozolomide Antineoplastic Agents, Alkylating DNA Repair Enzymes Drug Resistance, Neoplasm Tumor Suppressor Proteins Cell Cycle Humans Machine Learning Brain Neoplasms Cell Line, Tumor Cell Proliferation Cell Movement Glioblastoma DNA Modification Methylases
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Exploring Mechanisms and Biomarkers of Breast Cancer Invasion and Migration: An Explainable Gene-Pathway-Compounds Neural Network.

Cancer medicine Mar 1, 2025
BACKGROUNDS: Exploring the molecular features that drive breast cancer invasion and migration remains an important biological and clinical challenge. In recent years, the use of interpretable machine learning models has enhanced our understanding of ...
Gene Expression Regulation, Neoplastic Cell Movement Neoplasm Invasiveness Female Humans Breast Neoplasms Neural Networks, Computer Biomarkers, Tumor Gene Regulatory Networks
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