AIMC Topic: Cell Proliferation

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Caloric restriction and IGF-I administration promote rabbit fecundity: Possible interrelationships and mechanisms of action.

Theriogenology Dec 18, 2016
The aim of these in vivo and in vitro studies was to examine the influence of caloric restriction (CR), and the administration of insulin-like growth factor (IGF-I), on rabbit fecundity and to understand the interrelationships between CR and IGF-I, a...
Fertility Cells, Cultured Litter Size Ovary Caloric Restriction Cell Proliferation Rabbits Granulosa Cells Leptin Female Animals Insulin-Like Growth Factor I Estradiol Progesterone
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Apoptosis of rat hepatic stellate cells induced by diallyl trisulfide and proteomics profiling in vitro.

Canadian journal of physiology and pharmacology Nov 18, 2016
Diallyl trisulfide (DATS), a major garlic derivative, inhibits cell proliferation and triggers apoptosis in a variety of cancer cell lines. However, the effects of DATS on hepatic stellate cells (HSCs) remain unknown. The aim of this study was to ana...
Allyl Compounds Apoptosis Animals Cell Cycle Cell Survival Rats Hepatic Stellate Cells Proteomics Sulfides Garlic Cell Proliferation Gene Expression Regulation
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G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation.

Journal of vascular research Apr 12, 2016
Vascular smooth muscle cell (VSMC) migration and proliferation is central to neointima formation in vein graft failure following coronary artery bypass. However, there are currently no pharmacological interventions that prevent vein graft failure thr...
Dose-Response Relationship, Drug Receptors, G-Protein-Coupled rho-Associated Kinases rhoA GTP-Binding Protein Muscle, Smooth, Vascular Thiazolidines Hydrazones Thiourea HEK293 Cells Humans Time Factors Cell Proliferation Naphthols Signal Transduction Myocytes, Smooth Muscle Purinones Cell Movement Endothelial Cells Saphenous Vein Actin Cytoskeleton Aminosalicylic Acids
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Nuquantus: Machine learning software for the characterization and quantification of cell nuclei in complex immunofluorescent tissue images.

Scientific reports Mar 23, 2016
Determination of fundamental mechanisms of disease often hinges on histopathology visualization and quantitative image analysis. Currently, the analysis of multi-channel fluorescence tissue images is primarily achieved by manual measurements of tissu...
Humans Cell Proliferation Cell Survival Myocytes, Cardiac Cell Nucleus Machine Learning Fluorescent Antibody Technique Software Animals Image Processing, Computer-Assisted Microscopy, Confocal
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Optimized Repopulation of Tendon Hydrogel: Synergistic Effects of Growth Factor Combinations and Adipose-Derived Stem Cells.

Hand (New York, N.Y.) Mar 15, 2016
Tendon-derived extracellular matrix (ECM) hydrogel has been shown to augment tendon healing in vivo. We hypothesized that reseeding of the gel with adipose-derived stem cells (ASCs) could further assist repopulation of the gel and that combinations ...
Tissue Scaffolds Tendons Guided Tissue Regeneration Stem Cell Transplantation Hydrogels Animals Intercellular Signaling Peptides and Proteins Drug Synergism Cell Proliferation Extracellular Matrix Rats, Sprague-Dawley Tissue Engineering Dose-Response Relationship, Drug Adipose Tissue
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Locality Sensitive Deep Learning for Detection and Classification of Nuclei in Routine Colon Cancer Histology Images.

IEEE transactions on medical imaging Feb 4, 2016
Detection and classification of cell nuclei in histopathology images of cancerous tissue stained with the standard hematoxylin and eosin stain is a challenging task due to cellular heterogeneity. Deep learning approaches have been shown to produce en...
Colonic Neoplasms Image Interpretation, Computer-Assisted Cell Nucleus Histocytochemistry Neural Networks, Computer Machine Learning Colon Cell Proliferation Humans
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Effect of imatinib on growth of experimental endometriosis in rats.

European journal of obstetrics, gynecology, and reproductive biology Dec 25, 2015
OBJECTIVE: Currently, medical and surgical treatment options for endometriosis are limited due to suboptimal efficacy, and also safety and tolerance issues. Long-term use of gonadotrophin-releasing hormone analogs, androgenes, and the danazol, which ...
Female Animals Rats Peritoneum Imatinib Mesylate Nitriles Aromatase Inhibitors Ovarian Follicle Anastrozole Peritoneal Diseases Proto-Oncogene Proteins c-kit bcl-2-Associated X Protein Endometriosis Vascular Endothelial Growth Factor A Triazoles Transplantation, Autologous Cell Proliferation Angiogenesis Inhibitors Endometrium Disease Models, Animal
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Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults.

Clinical nutrition (Edinburgh, Scotland) Dec 24, 2015
BACKGROUND & AIMS: Mortality resulting from influenza (flu) virus infections occurs primarily in the elderly through declining immunity. Studies in mice have suggested beneficial effects of selenium (Se) supplementation on immunity to flu but similar...
Immunity, Cellular Antibodies, Viral Cell Proliferation Body Mass Index Dose-Response Relationship, Drug Immunoglobulins Dietary Supplements Humans Male Immunoglobulin A Cytokines Middle Aged Double-Blind Method Female Diet Saliva T-Lymphocytes Selenium Influenza, Human Influenza Vaccines
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Modulatory role of garlicin in migration and invasion of intrahepatic cholangiocarcinoma via PI3K/AKT pathway.

International journal of clinical and experimental pathology Nov 1, 2015
Increasing evidences have indicated the role of garlicin in inhibiting the progression of various tumors including glioma, pulmonary carcinoma and pancreatic carcinoma, via mediating cell apoptosis or cell cycle. The regulatory effect and related mol...
Humans Cell Line, Tumor Allyl Compounds Cell Proliferation Protein Kinase Inhibitors Antineoplastic Agents, Phytogenic Cholangiocarcinoma Phosphoinositide-3 Kinase Inhibitors Phosphorylation Phosphatidylinositol 3-Kinase Proto-Oncogene Proteins c-akt Signal Transduction Bile Duct Neoplasms Cell Movement Disulfides Neoplasm Invasiveness Dose-Response Relationship, Drug
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Effect of earthworm active protein on fibroblast proliferation and its mechanism.

Pharmaceutical biology Oct 7, 2015
CONTEXT: Earthworms have been used as a traditional medicine in China from thousands of years. In recent years, research has demonstrated that earthworm extracts might promote wound healing; however, its mechanism is still unknown.
Cell Proliferation Fibroblasts Dose-Response Relationship, Drug Cell Survival NIH 3T3 Cells Biological Factors Oligochaeta Animals Mice
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