AIMC Topic: Cell Proliferation

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Graphene oxide-doping improves the biocompatibility and separation performance of polyethersulfone hollow fiber membranes for bioartificial kidney application.

Journal of colloid and interface science Dec 27, 2017
HYPOTHESIS: Graphene oxide (GO)-doping in polyethersulfone hollow fiber membranes (PES HFMs) improves the biocompatibility and separation performance for bioartificial kidney (BAK) application.
Graphite Humans Oxides HEK293 Cells Kidney Surface Properties Cell Proliferation Sulfones Particle Size Membranes, Artificial Polymers Porosity Biocompatible Materials
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Human Wharton's Jelly-Derived Stem Cells Display a Distinct Immunomodulatory and Proregenerative Transcriptional Signature Compared to Bone Marrow-Derived Stem Cells.

Stem cells and development Dec 21, 2017
Mesenchymal stromal cells (MSCs) are multipotent stem cells with immunosuppressive and trophic support functions. While MSCs from different sources frequently display a similar appearance in culture, they often show differences in their surface marke...
Bone Marrow Cells Gene Expression Regulation Immunomodulation Gene Ontology Cell Adhesion Humans Gene Expression Profiling Cell Line, Tumor Cell Proliferation Mesenchymal Stem Cells
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Lycopene-rich extract from red guava (Psidium guajava L.) displays cytotoxic effect against human breast adenocarcinoma cell line MCF-7 via an apoptotic-like pathway.

Food research international (Ottawa, Ont.) Oct 27, 2017
This study investigated a lycopene-rich extract from red guava (LEG) for its chemical composition using spectrophotometry, mass spectrometry, attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR), and computational studies. ...
Cell Survival MCF-7 Cells Plant Extracts DNA Fragmentation Tandem Mass Spectrometry Humans Cell Proliferation NIH 3T3 Cells Female Mice, Inbred BALB C Psidium Cell Membrane Animals Apoptosis Mice Reactive Oxygen Species Cell Cycle Lycopene
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Effects of salinity on bacterial communities, Maillard reactions, isoflavone composition, antioxidation and antiproliferation in Korean fermented soybean paste (doenjang).

Food chemistry Oct 26, 2017
The purpose of this study was to investigate bacterial communities and health-benefit-related parameters in doenjang prepared with various brine concentrations (8, 12, 16, and 20%). Phenolic, flavonoid, melanoidin and isoflavone contents, antioxidati...
Soy Foods Isoflavones Fermented Foods Lactobacillus HT29 Cells Microbial Consortia Humans Maillard Reaction Bacteria Drug Screening Assays, Antitumor Antioxidants Polymers Cell Proliferation Hydrogen-Ion Concentration Phenols Fermentation
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An Advanced Deep Learning Approach for Ki-67 Stained Hotspot Detection and Proliferation Rate Scoring for Prognostic Evaluation of Breast Cancer.

Scientific reports Jun 12, 2017
Being a non-histone protein, Ki-67 is one of the essential biomarkers for the immunohistochemical assessment of proliferation rate in breast cancer screening and grading. The Ki-67 signature is always sensitive to radiotherapy and chemotherapy. Due t...
Deep Learning Cell Proliferation Immunohistochemistry Ki-67 Antigen Pathology, Clinical Reproducibility of Results Sensitivity and Specificity Breast Neoplasms Biomarkers, Tumor Humans Female
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Novel Imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxides as antiproliferative trypanosoma cruzi drugs: Computational screening from neural network, synthesis and in vivo biological properties.

European journal of medicinal chemistry May 1, 2017
A new family of imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxide with antiproliferative Trypanosoma cruzi properties was identified from a neural network model published by our group. The synthesis and evaluation of this new class of trypanocidal agents ...
Fibroblasts Neural Networks, Computer Molecular Structure Dose-Response Relationship, Drug Macrophages Trypanosoma cruzi Animals Imidazoles Thiadiazines Mice Structure-Activity Relationship Cell Proliferation
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Anticancer and anti-inflammatory activities of girinimbine isolated from .

Drug design, development and therapy Dec 28, 2016
Therapy that directly targets apoptosis and/or inflammation could be highly effective for the treatment of cancer. is an edible herb that has been traditionally used for cancer treatment as well as inflammation. Here, we describe that girinimbine, a...
Murraya Cell Survival Antineoplastic Agents, Phytogenic Drug Screening Assays, Antitumor Structure-Activity Relationship Anti-Inflammatory Agents, Non-Steroidal Zebrafish Alkaloids HT29 Cells Tumor Cells, Cultured Nitric Oxide Cell Proliferation Apoptosis Lipopolysaccharides Dose-Response Relationship, Drug Humans Cytokines Animals Mice
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Caloric restriction and IGF-I administration promote rabbit fecundity: Possible interrelationships and mechanisms of action.

Theriogenology Dec 18, 2016
The aim of these in vivo and in vitro studies was to examine the influence of caloric restriction (CR), and the administration of insulin-like growth factor (IGF-I), on rabbit fecundity and to understand the interrelationships between CR and IGF-I, a...
Estradiol Progesterone Cell Proliferation Rabbits Granulosa Cells Leptin Fertility Litter Size Cells, Cultured Ovary Female Caloric Restriction Animals Insulin-Like Growth Factor I
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Apoptosis of rat hepatic stellate cells induced by diallyl trisulfide and proteomics profiling in vitro.

Canadian journal of physiology and pharmacology Nov 18, 2016
Diallyl trisulfide (DATS), a major garlic derivative, inhibits cell proliferation and triggers apoptosis in a variety of cancer cell lines. However, the effects of DATS on hepatic stellate cells (HSCs) remain unknown. The aim of this study was to ana...
Animals Rats Proteomics Cell Proliferation Apoptosis Cell Survival Hepatic Stellate Cells Garlic Sulfides Gene Expression Regulation Allyl Compounds Cell Cycle
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G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation.

Journal of vascular research Apr 12, 2016
Vascular smooth muscle cell (VSMC) migration and proliferation is central to neointima formation in vein graft failure following coronary artery bypass. However, there are currently no pharmacological interventions that prevent vein graft failure thr...
Signal Transduction Cell Movement Dose-Response Relationship, Drug Receptors, G-Protein-Coupled rho-Associated Kinases Humans Time Factors Cell Proliferation Thiourea HEK293 Cells Myocytes, Smooth Muscle Endothelial Cells Actin Cytoskeleton rhoA GTP-Binding Protein Muscle, Smooth, Vascular Thiazolidines Hydrazones Aminosalicylic Acids Naphthols Purinones Saphenous Vein
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