AIMC Topic: Diet, High-Fat

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CDKN1A and EGR1 are key genes for endoplasmic reticulum stress-induced ferroptosis in MASH.

Free radical biology & medicine Aug 16, 2025
Metabolic dysfunction-associated steatohepatitis (MASH) is a complex liver disease whose pathogenesis involving endoplasmic reticulum (ER) stress and ferroptosis. However, key regulatory genes remain poorly understood, hindering the development of ef...
Cyclin-Dependent Kinase Inhibitor p21 Mice, Inbred C57BL Disease Models, Animal Hep G2 Cells Ferroptosis Non-alcoholic Fatty Liver Disease Gene Expression Regulation Liver Diet, High-Fat Humans Animals Mice Fatty Liver Male Early Growth Response Protein 1 Endoplasmic Reticulum Stress Phenylenediamines
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Tribulus terrestris L. Extract Alleviates Atherosclerosis by Suppressing TNF-α-Mediated Macrophage Inflammation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology Aug 15, 2025
Atherosclerosis (AS) is a major contributor to cardiovascular disease. In traditional Chinese medicine, Tribulus terrestris L., or Baijili (BJL), has shown therapeutic effects on inflammation and cardiovascular issues. Our prior research indicated th...
Macrophages Animals Mice, Inbred C57BL Molecular Docking Simulation Tumor Necrosis Factor-alpha Male Mice Diet, High-Fat RAW 264.7 Cells Apolipoproteins E Mice, Knockout Plant Extracts Tribulus Atherosclerosis Inflammation
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Quantification of hepatic steatosis in histologic images by deep learning method.

Journal of X-ray science and technology Jan 1, 2019
OBJECTIVE: To develop and test a novel method for automatic quantification of hepatic steatosis in histologic images based on the deep learning scheme designed to predict the fat ratio directly, which aims to improve accuracy in diagnosis of non-alco...
Rabbits Non-alcoholic Fatty Liver Disease Liver Diet, High-Fat Tomography, X-Ray Computed Female Male Deep Learning Animals Neural Networks, Computer
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Single subject transcriptome analysis to identify functionally signed gene set or pathway activity.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing Jan 1, 2018
Analysis of single-subject transcriptome response data is an unmet need of precision medicine, made challenging by the high dimension, dynamic nature and difficulty in extracting meaningful signals from biological or stochastic noise. We have propose...
Humans Mice, Inbred NZB Mice, 129 Strain Animals Mice, Inbred DBA Male Computational Biology Mice, Inbred C57BL Precision Medicine Oligonucleotide Array Sequence Analysis Gene Expression Profiling Databases, Genetic Gene Regulatory Networks Diet, High-Fat Female Mice, Inbred Strains Gene Ontology Mice
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[Effects of Lactobacillus paracasei N1115 combined with fructooligosaccharides on non-alcoholic fatty liver disease induced by high-fat diet in mice].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology Dec 20, 2017
To investigate the effects of Lactobacillus paracasei N1115 combined with fructooligosaccharides (FOS) on non-alcoholic fatty liver disease (NAFLD) in mice and its possible mechanism. A total of 50 male C57 mice were randomly and equally divided in...
Rats, Sprague-Dawley Lacticaseibacillus paracasei Mice Liver Animals Diet, High-Fat Rats Non-alcoholic Fatty Liver Disease Male Probiotics Oligosaccharides
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