Lymphatic filariasis (LF) is a mosquito-borne neglected tropical disease that causes disfiguring of the affected extremities, often leading to permanent disability and stigma. Described as a disease of poverty, the impact of socioeconomic indicators ...
PURPOSE: The purpose of this study was to develop models that predict which patients with glaucoma will progress to require surgery, combining structured data from electronic health records (EHRs) and retinal fiber layer optical coherence tomography ...
BACKGROUND: Current treatment paradigms assume aortic regurgitation (AR) patients to be a homogenous population, but varied courses of disease progression and outcomes are observed clinically.
BACKGROUND: Undifferentiated arthritis (UA) often develops into rheumatoid arthritis (RA), but predicting disease progression from seronegative UA remains challenging because seronegative RA often does not meet the classification criteria. This study...
International journal of molecular sciences
40076962
Cell-mediated immunity and chronic inflammation are hallmarks of chronic kidney disease (CKD). Growth differentiation factor 15 (GDF15) is a marker of inflammation and an integrative signal in stress conditions. Epidermal growth factor (EGF) is a tub...
BACKGROUND: Early prediction of progression in dementia is of major importance for providing patients with adequate clinical care, with considerable impact on the organization of the whole healthcare system.
Non-alcoholic fatty liver disease (NAFLD) affects about 25% of adults worldwide. Its advanced form, non-alcoholic steatohepatitis (NASH), is a major cause of liver fibrosis, but there are no non-invasive tests for diagnosing or preventing it. In our ...
PURPOSE: Clinical management of pediatric chronic kidney disease requires estimation of glomerular filtration rate (eGFR). Currently, eGFR is determined by two endogenous markers measured in blood: serum creatine (SCr) and cystatin C (CysC). Machine ...
The progression of Alzheimer's disease (AD) involves complex changes in brain structure and function that are driven by their interaction, making structure-function coupling (SFC) a valuable indicator for early detection of AD. Static SFC refers to t...
OBJECTIVE: Identification of clinically meaningful subphenotypes of disease progression can enhance the understanding of disease heterogeneity and underlying pathophysiology. In this study, we propose a machine learning framework to identify subpheno...