AIMC Topic: Disease Progression
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Peripheral HLA-DRCD141 Classical Monocytes Predict Relapse Risk and Worsening in Multiple Sclerosis.
Neurology(R) neuroimmunology & neuroinflammation
Jul 3, 2025
BACKGROUND AND OBJECTIVES: Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the CNS characterized by a heterogeneous disease trajectory, highlighting the need for biomarkers to predict disease activity. Current disease-monitorin...
Deep learning-based quantitative analysis of glomerular morphology in IgA nephropathy whole slide images and its prognostic implications.
Scientific reports
Jul 2, 2025
Kidney pathology of immunoglobulin A nephropathy (IgAN), which is the key finding of both diagnosis and risk stratification, involves labor-intensive manual interpretation as well as unavoidable interpreter-dependent variabilities. We propose artific...
Profiling short-term longitudinal severity progression and associated genes in COVID-19 patients using EHR and single-cell analysis.
Scientific reports
Jul 1, 2025
Here we propose CovSF, a deep learning model designed to track and forecast short-term severity progression of COVID-19 patients using longitudinal clinical records. The motivation stems from the need for timely medical resource allocation, improved ...
Regulatory T cells and matrix-producing cancer associated fibroblasts contribute on the immune resistance and progression of prognosis related tumor subtypes in ccRCC.
Scientific reports
Jul 1, 2025
Clear cell renal cell carcinoma (ccRCC) is a prevalent malignant tumor in the field of urology. The effect of cell heterogeneity on the prognosis and reaction to treatment of ccRCC in large populations is still unclear. By analyzing public single cel...
Unraveling the role of perineural invasion in cancer progression across multiple tumor types.
Medical oncology (Northwood, London, England)
Jun 26, 2025
Perineural invasion (PNI) refers to the infiltration of tumor cells into the connective tissue of nerves and is increasingly recognized as a pathological hallmark of multiple cancers, including pancreatic, prostate, colorectal, breast, and head and n...
Epicardial adipose tissue, myocardial remodelling and adverse outcomes in asymptomatic aortic stenosis: a post hoc analysis of a randomised controlled trial.
Heart (British Cardiac Society)
Jun 26, 2025
BACKGROUND: Epicardial adipose tissue represents a metabolically active visceral fat depot that is in direct contact with the left ventricular myocardium. While it is associated with coronary artery disease, little is known regarding its role in aort...
Progression and natural history of Atypical Parkinsonism (ATPARK): Protocol for a longitudinal follow-up study from an underrepresented population.
PloS one
Jun 26, 2025
BACKGROUND: Atypical Parkinsonian Syndromes (APS) form the third largest group of neurodegenerative disorders including Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA), and Corticobasal Syndrome (CBS). These conditions are charact...
A machine-learning-based approach to predict early hallmarks of progressive hearing loss.
Hearing research
Jun 6, 2025
Machine learning (ML) techniques are increasingly being used to improve disease diagnosis and treatment. However, the application of these computational approaches to the early diagnosis of age-related hearing loss (ARHL), the most common sensory def...
Auditory Threshold
Age Factors
Evoked Potentials, Auditory, Brain Stem
Disease Models, Animal
Animals
Presbycusis
Mice, Inbred C57BL
Male
Humans
Predictive Value of Tests
Disease Progression
Machine Learning
Mice
Signal Processing, Computer-Assisted
Phenotype
Cadherins
Female
Early Diagnosis
Hearing
Explainable machine learning model predicting neurological deterioration in Wilson's disease via MRI radiomics and clinical features.
Parkinsonism & related disorders
Jun 4, 2025
BACKGROUND: This study aims to build a machine learning (ML) model to predict the deterioration of neurological symptoms in Wilson's disease (WD) patients during short-term anti-copper therapy. The model combines brain T1WI MRI radiomics with clinica...
Autophagy crosstalk with the immune microenvironment in chronic myeloid leukemia and serves as a biomarker for diagnosis and progression.
Frontiers in immunology
May 28, 2025
BACKGROUND: Previous studies have shown that autophagy is closely related to the occurrence, development, and treatment resistance of chronic myeloid leukemia (CML) and has dual roles in promoting cell survival and inducing cell death.
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