AIMC Topic: Double-Blind Method

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Phase 1b Study of the Safety, Pharmacokinetics, and Disease-related Outcomes of the Matrix Metalloproteinase-9 Inhibitor Andecaliximab in Patients With Rheumatoid Arthritis.

Clinical therapeutics Dec 26, 2017
PURPOSE: Andecaliximab (GS-5745) is a highly selective monoclonal antibody against matrix metalloproteinase-9 (MMP9), a proteolytic enzyme implicated in the pathogenesis of rheumatoid arthritis (RA). This study assessed the safety and pharmacokinetic...
Infusions, Intravenous Double-Blind Method Matrix Metalloproteinase 9 Antirheumatic Agents Matrix Metalloproteinase Inhibitors Male Middle Aged Humans Arthritis, Rheumatoid Antibodies, Monoclonal, Humanized Female Antibodies, Monoclonal Aged
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Detection of delta-9-tetrahydrocannabinol (THC) in oral fluid, blood and urine following oral consumption of low-content THC hemp oil.

Forensic science international Dec 24, 2017
Hemp-derivative (Cannabis sativa L.) food products containing trace levels of Δ-9-tetrahydrocannabinol (THC) are proposed for consumption in Australia and New Zealand; however, it is unclear whether use of these products will negatively affect existi...
Middle Aged Plant Oils Double-Blind Method Immunoassay Saliva Humans Cross-Over Studies Female Cannabis Young Adult Dronabinol Adult Food Male
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Efficacy and safety of a fixed combination of intramuscular diclofenac 75 mg + thiocolchicoside 4 mg in the treatment of acute low back pain: a phase III, randomized, double blind, controlled trial.

European journal of physical and rehabilitation medicine Dec 21, 2017
BACKGROUND: The management of acute low back pain (LBP) is directed to obtain early and maximum relief of the local and regional pain, and to improve mobility and physical function.
Humans Double-Blind Method Injections, Intramuscular Male Female Italy Colchicine Middle Aged Low Back Pain Diclofenac Treatment Outcome Drug Combinations Pain Measurement
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Preoperative cesarean delivery intravenous acetaminophen treatment for postoperative pain control: a randomized double-blinded placebo control trial.

American journal of obstetrics and gynecology Dec 21, 2017
BACKGROUND: The United States currently has an opioid use disorder epidemic and research evaluating ways to minimize the use of opioids postsurgery are needed. One of these options is intravenous acetaminophen. If the use of preoperative intravenous ...
Analgesics, Opioid Administration, Intravenous Fetal Blood Acetaminophen Analgesics, Non-Narcotic Adult Length of Stay Pain Measurement Double-Blind Method Pain, Postoperative Preoperative Care Female Cesarean Section Young Adult Humans Prospective Studies Pregnancy
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Effects of carbohydrate mouth rinse and caffeine on high-intensity interval running in a fed state.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme Dec 20, 2017
The current study aims to identify if mouth rinsing with a 6% carbohydrate mouth-rinse (CMR) solution and mouth rinsing and ingestion of caffeine (CMR+CAFF) can affect exercise performance during steady-state (SS) running and high-intensity intervals...
Exercise Double-Blind Method Oxygen Consumption Exercise Test Running Humans Risk Factors Young Adult Adult Male Lactic Acid Caffeine Gastrointestinal Diseases Dietary Carbohydrates Fatigue High-Intensity Interval Training Heart Rate Athletic Performance Athletes Physical Endurance Mouthwashes
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Efficacy and safety of lebrikizumab in adult patients with mild-to-moderate asthma not receiving inhaled corticosteroids.

Respiratory medicine Dec 13, 2017
BACKGROUND: Asthma is a heterogeneous and complex disease in both its clinical course and response to treatment. IL-13 is central to Type 2 inflammation and contributes to many features of asthma. In a previous Phase 2 study, lebrikizumab, an anti-IL...
Cyclopropanes Middle Aged Humans Sulfides Glucocorticoids Antibodies, Monoclonal Female Treatment Failure Severity of Illness Index Double-Blind Method Adult Quinolines Injections, Subcutaneous Asthma Forced Expiratory Volume Administration, Inhalation Treatment Outcome Male Anti-Asthmatic Agents Acetates
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Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial.

Clinical nutrition (Edinburgh, Scotland) Dec 12, 2017
BACKGROUND & AIMS: Melatonin may benefit diabetic people with coronary heart disease (CHD) through its beneficial effects on biomarkers of oxidative stress and cardio-metabolic risk. This investigation evaluated the effects of melatonin administratio...
Double-Blind Method Cholesterol, HDL Glutathione Coronary Disease Melatonin Antioxidants Nitric Oxide Malondialdehyde C-Reactive Protein Blood Pressure Middle Aged Blood Glucose Aged Insulin Aged, 80 and over Oxidative Stress Male Diabetes Mellitus, Type 2 Humans Biomarkers Female
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High-Dose Vitamin D Administration Is Associated With Increases in Hemoglobin Concentrations in Mechanically Ventilated Critically Ill Adults: A Pilot Double-Blind, Randomized, Placebo-Controlled Trial.

JPEN. Journal of parenteral and enteral nutrition Dec 11, 2017
BACKGROUND: Anemia and vitamin D deficiency are highly prevalent in critical illness, and vitamin D status has been associated with hemoglobin concentrations in epidemiologic studies. We examined the effect of high-dose vitamin D therapy on hemoglobi...
Critical Care Critical Illness Cholecalciferol Female Male Humans Aged Pilot Projects Middle Aged Double-Blind Method Respiration, Artificial Vitamins Hepcidins Hemoglobins
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High-dose atorvastatin versus moderate dose on early vascular protection after ST-elevation myocardial infarction.

Drug design, development and therapy Dec 4, 2017
BACKGROUND AND AIM: Clinical benefits of early high-dose statin therapy after acute coronary syndromes are widely known; however, there is poor evidence on the specific setting of ST-elevation myocardial infarction (STEMI) and dose-dependent effects ...
Aged, 80 and over Young Adult Adult Male Middle Aged Adolescent Humans Prospective Studies Female Aged Inflammation Endothelial Cells Dose-Response Relationship, Drug Atorvastatin Double-Blind Method Anticholesteremic Agents ST Elevation Myocardial Infarction Endothelium, Vascular
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Comparative Study Between Conventional Fasting Versus Overnight Infusion of Lipid or Carbohydrate on Insulin and Free Fatty Acids in Obese Patients Undergoing Elective On-pump Coronary Artery Bypass Grafting. A Prospective Randomized Trial.

Journal of cardiothoracic and vascular anesthesia Nov 24, 2017
OBJECTIVES: Postoperative insulin resistance represents a major component of postoperative metabolic disorder. The authors compared the effects of preoperative infusion of lipid emulsion or carbohydrate to conventional preoperative fasting on postope...
Aged Adult Male Middle Aged Fasting Elective Surgical Procedures Carbohydrates Fatty Acids, Nonesterified Insulin Obesity Double-Blind Method Humans Prospective Studies Female Coronary Artery Bypass Fat Emulsions, Intravenous
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