AIMC Topic: Doxorubicin

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Multi-Responsive Bottlebrush-Like Unimolecules Self-Assembled Nano-Riceball for Synergistic Sono-Chemotherapy.

Small methods Sep 2, 2020
Improved drug loading content, bioavailability, and controlled release in targeted tissue have been major bottlenecks in the design of precision nanomedicine. Herein, a tumor-specific and multiple-stimuli responsive nano-riceball is proposed and vali...
Doxorubicin Micelles Nanomedicine Animals Liver Neoplasms Carcinoma, Hepatocellular Mice
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Super-Soft and Super-Elastic DNA Robot with Magnetically Driven Navigational Locomotion for Cell Delivery in Confined Space.

Angewandte Chemie (International ed. in English) Dec 23, 2019
Soft organisms such as earthworms can access confined, narrow spaces, inspiring scientists to fabricate soft robots for in vivo manipulation of cells or tissues and minimally invasive surgery. We report a super-soft and super-elastic magnetic DNA hyd...
Animals Mice Drug Carriers Nucleic Acid Amplification Techniques Doxorubicin Robotics Hydrogels DNA Porosity Myocytes, Smooth Muscle Microscopy, Fluorescence Magnetics Shear Strength Gene Transfer Techniques
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Label-Free Estimation of Therapeutic Efficacy on 3D Cancer Spheres Using Convolutional Neural Network Image Analysis.

Analytical chemistry Oct 24, 2019
Despite recent advances in cancer treatment, developing better therapeutic reagents remains an essential task for oncologists. To accurately characterize drug efficacy, 3D cell culture holds great promise as opposed to conventional 2D monolayer cultu...
Microfluidic Analytical Techniques Neural Networks, Computer Doxorubicin Breast Neoplasms Dose-Response Relationship, Drug Optical Imaging Humans Image Processing, Computer-Assisted Cell Survival Tumor Cells, Cultured Drug Screening Assays, Antitumor Cell Proliferation Antibiotics, Antineoplastic Structure-Activity Relationship Equipment Design
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Design and synthesis of new phthalazine-based derivatives as potential EGFR inhibitors for the treatment of hepatocellular carcinoma.

Bioorganic chemistry Dec 31, 2018
Searching for new leads in the battle of cancer will never ends, we herein disclose the design and synthesis of new phthalazine derivatives and their in vitro and in vivo testing for their antiproliferative activity. Phthalazine was selected as a pri...
Humans Doxorubicin Molecular Docking Simulation ErbB Receptors Cell Proliferation Phthalazines Antineoplastic Agents Hep G2 Cells Protein Kinase Inhibitors Liver Neoplasms Drug Screening Assays, Antitumor Carcinoma, Hepatocellular Cisplatin
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Hypoxia-responsive micelles self-assembled from amphiphilic block copolymers for the controlled release of anticancer drugs.

Journal of materials chemistry. B Dec 12, 2018
Amphiphilic block copolymers poly(ethylene glycol)-block-poly(methacrylic acid-co-2-nitroimidazole methacrylate) (PEG-b-P(MAA-co-NIMA)) were synthesized by the combination of atom transfer radical polymerization (ATRP), hydrolysis and EDC reactions. ...
Delayed-Action Preparations Tumor Hypoxia Doxorubicin Micelles Hydrophobic and Hydrophilic Interactions Humans Methacrylates Drug Delivery Systems HEK293 Cells Antineoplastic Agents Drug Carriers Polyethylene Glycols
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Investigation of magnetic silica with thermoresponsive chitosan coating for drug controlled release and magnetic hyperthermia application.

Materials science & engineering. C, Materials for biological applications Nov 30, 2018
In this study, a drug delivery system for chemo-hyperthermia applications is proposed and fabricated. The delivery system consists of magnetic-silica (MagSi) particles being encapsulated within a pH/thermo-responsive chitosan‑g‑N‑isopropylacrylamide ...
Drug Delivery Systems Humans Delayed-Action Preparations Silicon Dioxide Nanoparticles Temperature Hydrogen-Ion Concentration Acrylamides Doxorubicin Magnetic Fields Drug Liberation Magnetics HeLa Cells Spectroscopy, Fourier Transform Infrared Chitosan
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Preliminary study on alginate/NIPAM hydrogel-based soft microrobot for controlled drug delivery using electromagnetic actuation and near-infrared stimulus.

Biomedical microdevices Nov 16, 2018
Currently, microrobots are receiving attention because of their small size and motility, which can be applied to minimal invasive therapy. Additionally, various microrobots using hydrogel with the characteristics of biocompatibility and biodegradabil...
Humans Drug Delivery Systems Cell Line, Tumor Cell Survival Robotics Alginates Acrylamides Infrared Rays Electromagnetic Phenomena Doxorubicin Hydrogels Drug Liberation Microtechnology
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Cell-Like Micromotors.

Accounts of chemical research Aug 3, 2018
In the past decade, versatile micro- and nanosized machines have emerged as active agents for large-scale detoxification, sensing, microfabrication, and many other promising applications. Micromachines have also been envisioned as the next advancemen...
Magnetic Phenomena Spermatocytes Doxorubicin Biomimetics Drug Liberation Bacteria Nanoparticles Robotics Equipment Design Microtechnology Erythrocytes Blood Platelets Cell Membrane Drug Delivery Systems Animals Male
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Predicting Treatment Response to Intra-arterial Therapies for Hepatocellular Carcinoma with the Use of Supervised Machine Learning-An Artificial Intelligence Concept.

Journal of vascular and interventional radiology : JVIR Mar 14, 2018
PURPOSE: To use magnetic resonance (MR) imaging and clinical patient data to create an artificial intelligence (AI) framework for the prediction of therapeutic outcomes of transarterial chemoembolization by applying machine learning (ML) techniques.
Magnetic Resonance Imaging Predictive Value of Tests Neoplasm Staging Doxorubicin Chemoembolization, Therapeutic Ethiodized Oil Antineoplastic Agents Adult Liver Neoplasms Carcinoma, Hepatocellular Humans Sensitivity and Specificity Treatment Outcome Machine Learning Male Contrast Media Retrospective Studies Middle Aged Female Aged
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Chemical characterization, antioxidant, genotoxic and in vitro cytotoxic activity assessment of Juniperus communis var. saxatilis.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Dec 26, 2017
Chemical composition and antioxidative, genotoxic and cytotoxic potential of essential oil (EO) and post-distillation waste (PDW) of Serbian Juniperus communis L. var. saxatilis Pall. was studied in human lung carcinoma (A549) and normal lung fibrobl...
Humans Female Animals Male Cell Line, Tumor Mutagens Antioxidants Cell Division Plant Extracts G2 Phase Juniperus Chromatography, Liquid Drug Screening Assays, Antitumor Rats Tandem Mass Spectrometry Apoptosis Gas Chromatography-Mass Spectrometry Cell Line Doxorubicin Antineoplastic Agents, Phytogenic
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