AIMC Topic: Drug Combinations
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Predict effective drug combination by deep belief network and ontology fingerprints.
Journal of biomedical informatics
Aug 3, 2018
The synergistic effect of drug combination is one of the most desirable properties for treating cancer. However, systematically predicting effective drug combination is a significant challenge. We report here a novel method based on deep belief netwo...
Artificial neural networks (ANNs) and partial least squares (PLS) regression in the quantitative analysis of cocrystal formulations by Raman and ATR-FTIR spectroscopy.
Journal of pharmaceutical and biomedical analysis
Jun 4, 2018
The present work describes the development of an efficient, fast and accurate method for the quantification of polymer-based cocrystal formulations. Specifically, the content of carbamazepine-nicotinamide (CBZ/NIC) and ibuprofen-nicotinamide (IBU/NIC...
Polyvinyls
Calibration
Crystallization
Ibuprofen
Spectroscopy, Fourier Transform Infrared
Neural Networks, Computer
Chemistry, Pharmaceutical
Niacinamide
Least-Squares Analysis
Carbamazepine
Machine Learning
Polyethylene Glycols
Spectrum Analysis, Raman
Drug Compounding
Drug Combinations
Absorption, Physicochemical
A systematic and prospectively validated approach for identifying synergistic drug combinations against malaria.
Malaria journal
Apr 11, 2018
BACKGROUND: Nearly half of the world's population (3.2 billion people) were at risk of malaria in 2015, and resistance to current therapies is a major concern. While the standard of care includes drug combinations, there is a pressing need to identif...
Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients.
International journal of antimicrobial agents
Dec 22, 2017
Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models constructed with intermittent infusion data. However, the probability of targ...
Efficacy and safety of a fixed combination of intramuscular diclofenac 75 mg + thiocolchicoside 4 mg in the treatment of acute low back pain: a phase III, randomized, double blind, controlled trial.
European journal of physical and rehabilitation medicine
Dec 21, 2017
BACKGROUND: The management of acute low back pain (LBP) is directed to obtain early and maximum relief of the local and regional pain, and to improve mobility and physical function.
Sacubitril/Valsartan in an Elderly Patient with Heart Failure: A Case Report.
Cardiology
Dec 21, 2017
Sacubitril/valsartan has recently been approved for the treatment of heart failure with reduced ejection fraction. Given its recent introduction in the armamentarium for the treatment of heart failure (HF), "field-practice" evidence is required to de...
Innovative spectrophotometric methods for simultaneous estimation of the novel two-drug combination: Sacubitril/Valsartan through two manipulation approaches and a comparative statistical study.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Dec 17, 2017
Different innovative spectrophotometric methods were introduced for the first time for simultaneous quantification of sacubitril/valsartan in their binary mixture and in their combined dosage form without prior separation through two manipulation app...
A novel aspartic protease from Rhizomucor miehei expressed in Pichia pastoris and its application on meat tenderization and preparation of turtle peptides.
Food chemistry
Oct 23, 2017
A novel aspartic protease gene (RmproA) was cloned from the thermophilic fungus Rhizomucor miehei CAU432 and expressed in Pichia pastoris. The RmproA was successfully expressed in P. pastoris as an active extracellular protease. High protease activit...
The Safety and Efficacy of Adjuvant Hemostatic Agents During Laparoscopic Nephron-Sparing Surgery: Comparison of Tachosil and Floseal Versus No Hemostatic Agents.
Urology journal
Jan 23, 2017
PURPOSE: To compare the effectiveness of TachoSil and Floseal during laparoscopic nephron-sparing surgery (LNSS), and to evaluate postoperative complications, especially hemorrhage and urinary leakage.
Comparison of ropivacaine with and without fentanyl vs bupivacaine with fentanyl for postoperative epidural analgesia in bilateral total knee replacement surgery.
Journal of clinical anesthesia
Dec 22, 2016
STUDY OBJECTIVES: Pain after total knee replacement (TKR) interferes with early rehabilitation. Although the use of epidural bupivacaine in post-TKR patients is associated with effective analgesia, the associated motor blockade effect delays function...
Anesthetics, Local
Pain Measurement
Double-Blind Method
Pain, Postoperative
Bupivacaine
Treatment Outcome
Drug Combinations
Amides
Postoperative Care
Arthroplasty, Replacement, Knee
Pain Management
Patient Satisfaction
Nausea
Analgesia, Epidural
Ropivacaine
Analgesics, Opioid
Fentanyl
Osteoarthritis
Analgesia, Patient-Controlled
Humans
Prospective Studies
Female
Aged
Male
Middle Aged
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