AIMC Topic: Drug Combinations
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The role of sacubitril/valsartan in the treatment of chronic heart failure with reduced ejection fraction in hypertensive patients with comorbidities: From clinical trials to real-world settings.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Aug 21, 2020
BACKGROUND: Sacubitril/valsartan, the first agent to be approved in a new class of drugs called angiotensin receptor neprilysin inhibitors (ARNIs), has been shown to reduce cardiovascular mortality and morbidity compared to enalapril in outpatient su...
Detecting asthma exacerbations using daily home monitoring and machine learning.
The Journal of asthma : official journal of the Association for the Care of Asthma
Aug 14, 2020
OBJECTIVE: Acute exacerbations contribute significantly to the morbidity of asthma. Recent studies have shown that early detection and treatment of asthma exacerbations leads to improved outcomes. We aimed to develop a machine learning algorithm to d...
Making Sense of Pharmacovigilance and Drug Adverse Event Reporting: Comparative Similarity Association Analysis Using AI Machine Learning Algorithms in Dogs and Cats.
Topics in companion animal medicine
Sep 30, 2019
Drug-associated adverse events cause approximately 30 billion dollars a year of added health care expense, along with negative health outcomes including patient death. This constitutes a major public health concern. The US Food and Drug Administratio...
Predict effective drug combination by deep belief network and ontology fingerprints.
Journal of biomedical informatics
Aug 3, 2018
The synergistic effect of drug combination is one of the most desirable properties for treating cancer. However, systematically predicting effective drug combination is a significant challenge. We report here a novel method based on deep belief netwo...
Artificial neural networks (ANNs) and partial least squares (PLS) regression in the quantitative analysis of cocrystal formulations by Raman and ATR-FTIR spectroscopy.
Journal of pharmaceutical and biomedical analysis
Jun 4, 2018
The present work describes the development of an efficient, fast and accurate method for the quantification of polymer-based cocrystal formulations. Specifically, the content of carbamazepine-nicotinamide (CBZ/NIC) and ibuprofen-nicotinamide (IBU/NIC...
Drug Compounding
Absorption, Physicochemical
Calibration
Crystallization
Drug Combinations
Spectroscopy, Fourier Transform Infrared
Least-Squares Analysis
Polyethylene Glycols
Niacinamide
Chemistry, Pharmaceutical
Carbamazepine
Polyvinyls
Ibuprofen
Neural Networks, Computer
Machine Learning
Spectrum Analysis, Raman
A systematic and prospectively validated approach for identifying synergistic drug combinations against malaria.
Malaria journal
Apr 11, 2018
BACKGROUND: Nearly half of the world's population (3.2 billion people) were at risk of malaria in 2015, and resistance to current therapies is a major concern. While the standard of care includes drug combinations, there is a pressing need to identif...
Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients.
International journal of antimicrobial agents
Dec 22, 2017
Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models constructed with intermittent infusion data. However, the probability of targ...
Efficacy and safety of a fixed combination of intramuscular diclofenac 75 mg + thiocolchicoside 4 mg in the treatment of acute low back pain: a phase III, randomized, double blind, controlled trial.
European journal of physical and rehabilitation medicine
Dec 21, 2017
BACKGROUND: The management of acute low back pain (LBP) is directed to obtain early and maximum relief of the local and regional pain, and to improve mobility and physical function.
Sacubitril/Valsartan in an Elderly Patient with Heart Failure: A Case Report.
Cardiology
Dec 21, 2017
Sacubitril/valsartan has recently been approved for the treatment of heart failure with reduced ejection fraction. Given its recent introduction in the armamentarium for the treatment of heart failure (HF), "field-practice" evidence is required to de...
Innovative spectrophotometric methods for simultaneous estimation of the novel two-drug combination: Sacubitril/Valsartan through two manipulation approaches and a comparative statistical study.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Dec 17, 2017
Different innovative spectrophotometric methods were introduced for the first time for simultaneous quantification of sacubitril/valsartan in their binary mixture and in their combined dosage form without prior separation through two manipulation app...
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