AIMC Topic: Drug Compounding

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In-line monitoring and endpoint determination of percolation process of herbal medicine using ultraviolet spectroscopy combined with convolutional neural network.

The Journal of pharmacy and pharmacology
OBJECTIVES: As a common step in the herbal medicine production process, percolation usually lacks effective process monitoring methods and is often conducted with fixed process parameters. In this study, an in-line ultraviolet (UV) spectroscopy was u...

Calculation of therapeutic antibody viscosity with coarse-grained models, hydrodynamic calculations and machine learning-based parameters.

mAbs
High viscosity presents a challenge for manufacturing and drug delivery of therapeutic antibodies. The viscosity is determined by protein-protein interactions among many antibodies. Molecular simulation is a promising method to study protein-protein ...

Improvement of solubility and dissolution of ebastine by fabricating phosphatidylcholine/ bile salt bilosomes.

Pakistan journal of pharmaceutical sciences
Although ebastine (EBT) can impede histamine-induced skin allergic reaction and persuade long acting selective H1 receptor antagonistic effects but its poor water solubility circumscribed its clinical application. The main objective of this research ...

Comparative study of antibacterial activity between Schiff base nicotinic hydrazide derivative and its silver architected nanoparticles with atomic force microscopic study of bacterial cell wall.

Pakistan journal of pharmaceutical sciences
The threat of multi-drug resistant bacterial pathogens evokes researchers to synthesized safe and effective chemotherapeutic agents for nano-drug delivery system. In current study, Schiff base of nicotinic hydrazide(NHD) and its silver nanoparticles(...

Formulation and evaluation of antioxidant and antityrosinase activity of Polygonum amplexicaule herbal gel.

Pakistan journal of pharmaceutical sciences
Medicinal plants are long been used for pharmaceutical and cosmetic industry. Among medicinal plants, Polygonum amplexicaule of family polygonaceae has traditional use in medicines and skin care. P. amplexicaule belongs to genus Polygonum that contai...

Single Center Experience with Robot Technologies for Sterile Compounding: A Retrospective Review.

International journal of pharmaceutical compounding
The compounding of sterile medication admixtures is a labor-intensive process and subject to potential human error. The addition of robotic devices and workflow technology may mitigate some of the challenges of compounding sterile product admixtures,...

Implementation and evaluation of a sterile compounding robot in a satellite oncology pharmacy.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
PURPOSE: The purpose of this study was to quantify the impact of robotic technology on efficiency, accuracy, and cost in a satellite oncology pharmacy.

Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets.

Acta pharmaceutica (Zagreb, Croatia)
Pediatric, ibuprofen containing orodispersible tablets (ODTs) were prepared using the SeDeM expert system methodology. In order to facilitate formulation, directly compressible ibuprofen was employed (Ibuprofen DC 8TM) and characterized using its SeD...

POTENTIOMETRIC STUDY OF Pd(II) COMPLEXES OF SOME FLAVONOIDS IN WATER-METHANOL-1,4-DIOXANE-ACETONITRILE (MDM) MIXTURE.

Acta poloniae pharmaceutica
The potentiometric method was used to determine the protonation (dissociation) constants for morin, rutin and chrysin and the composition and formation constants of the Pd(II)-flavonoid complexes in the water/methanol/acetonitrile/1,4-dioxane mixture...