AIMC Topic: Drug Therapy, Combination

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Continuous Adaptive Population Reduction (CAPR) for Differential Evolution Optimization.

SLAS technology Jan 31, 2017
Differential evolution (DE) has been applied extensively in drug combination optimization studies in the past decade. It allows for identification of desired drug combinations with minimal experimental effort. This article proposes an adaptive popula...
Humans Artificial Intelligence Algorithms Computer Simulation Drug Discovery Drug Therapy, Combination
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Effectiveness of continuous wound infusion of local anesthetics after abdominal surgeries.

The Journal of surgical research Dec 29, 2016
BACKGROUND: To assess the effectiveness of continuous preperitoneal wound infusion of local anesthetic drug bupivacaine in providing pain relief, reducing opioid consumption, and enhancing postoperative recovery.
Infusions, Intralesional Treatment Outcome Follow-Up Studies Young Adult Anesthetics, Local Bupivacaine Humans Adult Pain Measurement Analgesics, Opioid Prospective Studies Male Double-Blind Method Morphine Middle Aged Female Pain, Postoperative Drug Therapy, Combination Adolescent Aged Abdomen Drug Administration Schedule Aged, 80 and over Infusions, Parenteral
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Intravenous Chlorothiazide Versus Enteral Metolazone to Augment Loop Diuretic Therapy in the Intensive Care Unit.

The Annals of pharmacotherapy Dec 16, 2016
BACKGROUND: In cases of loop diuretic resistance in the intensive care unit (ICU), recommendations for a specific second-line thiazide agent are lacking.
Chlorothiazide Furosemide Metolazone Humans Sodium Potassium Chloride Symporter Inhibitors Retrospective Studies Critical Illness Intensive Care Units Female Adult Male Administration, Oral Drug Therapy, Combination Diuresis Administration, Intravenous
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Patient-level meta-analysis of efficacy and hypoglycaemia in people with type 2 diabetes initiating insulin glargine 100U/mL or neutral protamine Hagedorn insulin analysed according to concomitant oral antidiabetes therapy.

Diabetes research and clinical practice Nov 9, 2016
AIMS: Evaluate efficacy and hypoglycaemia according to concomitant oral antidiabetes drug (OAD) in people with type 2 diabetes initiating insulin glargine 100U/mL (Gla-100) or neutral protamine Hagedorn (NPH) insulin once daily.
Glycated Hemoglobin Insulin Glargine Hypoglycemia Administration, Oral Drug Therapy, Combination Weight Gain Male Incidence Diabetes Mellitus, Type 2 Hypoglycemic Agents Treatment Outcome Randomized Controlled Trials as Topic Clinical Trials, Phase III as Topic Clinical Trials, Phase IV as Topic Insulin, Isophane Sulfonylurea Compounds Humans Female
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Adequate tacrolimus concentration for myasthenia gravis treatment.

European journal of neurology Nov 7, 2016
BACKGROUND AND PURPOSE: A single, oral dose of 3 mg/day tacrolimus, approved for myasthenia gravis (MG) treatment in Japan, was shown to reduce steroid dose and anti-acetylcholine receptor (AChR) antibody titers as well as to improve MG symptoms. How...
Middle Aged Treatment Outcome Prognosis Dose-Response Relationship, Drug Retrospective Studies Immunosuppressive Agents Japan Female Autoantibodies Drug Therapy, Combination Aged Tacrolimus Prednisolone Adult Myasthenia Gravis Male Humans
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Ombitasvir, paritaprevir, and ritonavir plus ribavirin for chronic hepatitis C virus genotype 4 infection in Egyptian patients with or without compensated cirrhosis (AGATE-II): a multicentre, phase 3, partly randomised open-label trial.

The lancet. Gastroenterology & hepatology Jun 16, 2016
BACKGROUND: In Egypt, chronic hepatitis C virus (HCV) infection occurs in around 10% of the population (about 8 million individuals), and is a leading cause of liver cirrhosis, hepatocellular carcinoma, and mortality. Although HCV genotype 4 constitu...
Macrocyclic Compounds Ribavirin Sustained Virologic Response Valine Adult Drug Administration Schedule Male Anilides Middle Aged Carbamates Adolescent Lactams, Macrocyclic Hepacivirus Antiviral Agents Liver Cirrhosis Administration, Oral Humans Genotype Proline Treatment Outcome Female Ritonavir Follow-Up Studies Aged Drug Therapy, Combination Cyclopropanes Aged, 80 and over Hepatitis C, Chronic Egypt Young Adult Sulfonamides
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Ombitasvir, paritaprevir, and ritonavir plus ribavirin in adults with hepatitis C virus genotype 4 infection and cirrhosis (AGATE-I): a multicentre, phase 3, randomised open-label trial.

The lancet. Gastroenterology & hepatology Jun 16, 2016
BACKGROUND: Hepatitis C virus (HCV) genotype 4 infection is most commonly reported in sub-Saharan Africa and the Middle East; however, prevalence is increasing worldwide through immigration. HCV genotype 4 accounts for 20% of all infections, but clin...
Aged, 80 and over Young Adult Adult Male Middle Aged Adolescent Antiviral Agents Genotype Treatment Outcome Follow-Up Studies Cyclopropanes Sulfonamides Humans Sustained Virologic Response Female Aged Drug Administration Schedule Anilides Carbamates Hepacivirus Lactams, Macrocyclic Proline Macrocyclic Compounds Ritonavir Ribavirin Drug Therapy, Combination Hepatitis C, Chronic Valine
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Impact of renal impairment on platelet reactivity and clinical outcomes during chronic dual antiplatelet therapy following coronary stenting.

European heart journal. Cardiovascular pharmacotherapy Dec 17, 2015
AIMS: Clinical utilization of dual antiplatelet therapy (DAPT) in patients with renal impairment (RI) following percutaneous coronary interventions (PCI) represents an urgent, unmet need choosing optimal agents, duration of treatment, and potential d...
Kaplan-Meier Estimate Platelet Aggregation Coronary Thrombosis Female Aged Male Middle Aged Postoperative Complications Humans Kidney Diseases Percutaneous Coronary Intervention Prospective Studies Stents Drug Therapy, Combination Blood Platelets Coronary Disease Platelet Aggregation Inhibitors
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Comparative risk of failure of ABC/3TC or TDF/FTC based first-line regimens in patients with a high viral load.

HIV medicine Aug 26, 2015
OBJECTIVES: To compare the efficacy, in current clinical practice, of first regimens containing abacavir with lamivudine (ABC/3TC) or tenofovir with emtricitabine (TDF/FTC) in patients with baseline viral load ≥100,000 HIV-1 RNA copies/mL.
Male Risk Assessment HIV Infections Viral Load Lamivudine Tenofovir Emtricitabine Humans Drug Therapy, Combination Prospective Studies France Female Propensity Score Treatment Failure Dideoxynucleosides
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Urodynamic Efficacy and Safety of Mirabegron Add-on Treatment with Tamsulosin for Japanese Male Patients with Overactive Bladder.

Lower urinary tract symptoms Feb 17, 2015
OBJECTIVES: To investigate urodynamic efficacy and safety of mirabegron add-on treatment with tamsulosin for Japanese male patients with overactive bladder (OAB).
Prospective Studies Aged Aged, 80 and over Male Middle Aged Treatment Outcome Humans Patient Safety Urological Agents Acetanilides Sulfonamides Tamsulosin Drug Therapy, Combination Urinary Bladder, Overactive Thiazoles Urination Adrenergic beta-Agonists Urodynamics
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