AIMC Topic: Endothelial Cells
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Computer vision to predict cell seeding coverage in re-endothelialized mouse lungs.
Scientific reports
Jul 19, 2025
Transplantation of donor grafts recellularized with recipient-derived or non-immunogenic universal cells is a potential means of reducing the graft rejection and post-transplant complications in lung transplantation. Achieving a fully recellularized ...
Machine learning identifies KRT8 dysregulation and endothelial remodeling in Moyamoya disease.
Scientific reports
Jul 7, 2025
Moyamoya disease (MMD) is a rare occlusive cerebrovascular disease, and its pathological mechanism remains unclear at present. The abnormal vascular remodeling may be involved in vascular endothelial cells. In this study, RNA seq was performed on the...
Role of tight junctions in three-dimensional mechanical model of blood-brain barrier.
Journal of biomechanics
Jun 7, 2025
The increasing prevalence of central nervous system (CNS) disorders has imposed a significant social and economic burden on healthcare systems. The blood-brain barrier (BBB) presents a major challenge for effective drug delivery to the brain, hinderi...
Nucleic acid spheres for treating capillarisation of liver sinusoidal endothelial cells in liver fibrosis.
Nature communications
May 15, 2025
Liver sinusoidal endothelial cells (LSECs) lose their characteristic fenestrations and become capillarized during the progression of liver fibrosis. Mesenchymal stem cell (MSC) transplantation can reverse this capillarization and reduce fibrosis, but...
The role of endothelial cell-related gene COL1A1 in prostate cancer diagnosis and immunotherapy: insights from machine learning and single-cell analysis.
Biology direct
Jan 8, 2025
BACKGROUND: Endothelial cells are integral components of the tumor microenvironment and play a multifaceted role in tumor immunotherapy. Targeting endothelial cells and related signaling pathways can improve the effectiveness of immunotherapy by norm...
3D electron microscopy for analyzing nanoparticles in the tumor endothelium.
Proceedings of the National Academy of Sciences of the United States of America
Dec 12, 2024
Delivering medical agents to diseased tissues has been challenging, leading researchers to study the in vivo transport process in the body for improving delivery. Many imaging techniques exist for mapping the distribution of medical agent-carrying na...
Predicting blood-brain barrier permeability of molecules with a large language model and machine learning.
Scientific reports
Jul 9, 2024
Predicting the blood-brain barrier (BBB) permeability of small-molecule compounds using a novel artificial intelligence platform is necessary for drug discovery. Machine learning and a large language model on artificial intelligence (AI) tools improv...
Boosting Clear Cell Renal Carcinoma-Specific Drug Discovery Using a Deep Learning Algorithm and Single-Cell Analysis.
International journal of molecular sciences
Apr 8, 2024
Clear cell renal carcinoma (ccRCC), the most common subtype of renal cell carcinoma, has the high heterogeneity of a highly complex tumor microenvironment. Existing clinical intervention strategies, such as target therapy and immunotherapy, have fail...
Machine learning based endothelial cell image analysis of patients undergoing descemet membrane endothelial keratoplasty surgery.
Biomedizinische Technik. Biomedical engineering
Mar 18, 2024
OBJECTIVES: In this study, we developed a machine learning approach for postoperative corneal endothelial cell images of patients who underwent Descemet's membrane keratoplasty (DMEK).
Combination Therapy-Based Adaptive Control for Organism Using Medicine Dosage Regulation Mechanism.
IEEE transactions on cybernetics
Dec 20, 2023
In this article, the optimal control strategy for organism is investigated by using the adaptive dynamic programming (ADP) method under the architecture of nonzero-sum games (NZSGs). First, a tumor model is established to formulate the interaction re...
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