AIMC Topic: Fluorouracil
Clear Filters Showing 21 to 30 of 35 articles
A machine learning algorithm predicts molecular subtypes in pancreatic ductal adenocarcinoma with differential response to gemcitabine-based versus FOLFIRINOX chemotherapy.
PloS one
Oct 2, 2019
PURPOSE: Development of a supervised machine-learning model capable of predicting clinically relevant molecular subtypes of pancreatic ductal adenocarcinoma (PDAC) from diffusion-weighted-imaging-derived radiomic features.
Neoplasm Proteins
Fluorouracil
Carcinoma, Pancreatic Ductal
Disease-Free Survival
Deoxycytidine
Middle Aged
Antineoplastic Combined Chemotherapy Protocols
Oxaliplatin
Pancreatic Neoplasms
Humans
Gemcitabine
Machine Learning
Irinotecan
Keratins, Hair-Specific
Retrospective Studies
Female
Keratins, Type II
Adult
Leucovorin
Survival Rate
Sensitivity and Specificity
Male
Prediction of irinotecan toxicity in metastatic colorectal cancer patients based on machine learning models with pharmacokinetic parameters.
Journal of pharmacological sciences
May 4, 2019
Irinotecan (CPT-11) is a drug used against a wide variety of tumors, which can cause severe toxicity, possibly leading to the delay or suspension of the cycle, with the consequent impact on the prognosis of survival. The main goal of this work is to ...
Machine learning predicts individual cancer patient responses to therapeutic drugs with high accuracy.
Scientific reports
Nov 6, 2018
Precision or personalized cancer medicine is a clinical approach that strives to customize therapies based upon the genomic profiles of individual patient tumors. Machine learning (ML) is a computational method particularly suited to the establishmen...
Gene-Specific Variant Classifier (DPYD-Varifier) to Identify Deleterious Alleles of Dihydropyrimidine Dehydrogenase.
Clinical pharmacology and therapeutics
Feb 2, 2018
Deleterious variants in dihydropyrimidine dehydrogenase (DPD, DPYD gene) can be highly predictive of clinical toxicity to the widely prescribed chemotherapeutic 5-fluorouracil (5-FU). However, there are very limited data pertaining to the functional ...
Humans
Machine Learning
Computer Simulation
Risk Assessment
Pharmacogenetics
Genotype
Dose-Response Relationship, Drug
Cell Survival
Predictive Value of Tests
Dihydrouracil Dehydrogenase (NADP)
Structure-Activity Relationship
Pharmacogenomic Testing
HEK293 Cells
Models, Molecular
Pharmacogenomic Variants
Gene Frequency
Fluorouracil
Protein Conformation
Inhibitory Concentration 50
Antimetabolites, Antineoplastic
HCT116 Cells
Mutation, Missense
5-fluorouracil combined with cisplatin and mitomycin C as an optimized regimen for hyperthermic intraperitoneal chemotherapy in gastric cancer.
Journal of surgical oncology
Dec 19, 2017
BACKGROUND AND OBJECTIVES: Optimized drug regimens for hyperthermic intraperitoneal chemotherapy (HIPEC) have not been standardized completely in patients with advanced gastric cancer (GC). We evaluated an optimized anti-tumor protocol comprising 5-f...
PAK6-Associated Support Vector Machine Classifier: A New Way to Evaluate Response and Survival of Gastric Cancer Treated by 5-FU/Oxaliplatin Chemotherapy.
EBioMedicine
Jul 5, 2017
Application of artificial neural network to investigate the effects of 5-fluorouracil on ribonucleotides and deoxyribonucleotides in HepG2 cells.
Scientific reports
Nov 18, 2015
Endogenous ribonucleotides and deoxyribonucleotides are essential metabolites that play important roles in a broad range of key cellular functions. Their intracellular levels could also reflect the action of nucleoside analogues. We investigated the ...
Hep G2 Cells
Cell Survival
Chromatography, Liquid
Metabolic Networks and Pathways
Models, Biological
Humans
Neural Networks, Computer
Deoxyribonucleotides
Fluorouracil
Guanine Nucleotides
Tandem Mass Spectrometry
Ribonucleotides
Inhibitory Concentration 50
Thymine Nucleotides
Adenine Nucleotides
Uracil Nucleotides
Cytosine Nucleotides
Use of Deep Learning to Evaluate Tumor Microenvironmental Features for Prediction of Colon Cancer Recurrence.
Cancer research communications
May 23, 2024
UNLABELLED: Deep learning may detect biologically important signals embedded in tumor morphologic features that confer distinct prognoses. Tumor morphologic features were quantified to enhance patient risk stratification within DNA mismatch repair (M...
[The Use of Platinum-Based Chemotherapy for Esophageal Cancer Patients with Impaired Renal Function].
Gan to kagaku ryoho. Cancer & chemotherapy
Dec 1, 2023
INTRODUCTION: The key drugs of first-line chemotherapy for metastatic esophageal cancer are 5-FU and cisplatin(CF). However, the treatment strategy for unfit patients of CF regimen remains controversial.
[A Case of Locally Advanced Sigmoid Colon Cancer Invading the Urinary Bladder Treated with Neoadjuvant Chemotherapy and Robot Assisted Urinary Bladder-Conserving Surgery].
Gan to kagaku ryoho. Cancer & chemotherapy
Feb 1, 2023
We report a case of 72s male with locally advanced sigmoid colon cancer. Colonoscopy revealed an advanced sigmoid colon cancer(AV 15 cm, type 2, semi-peripheral, deeper than T3). He was diagnosed as cT4bN2M0, cStage Ⅲc(Japanese Classification of Colo...
Stay Ahead of Medical AI
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.
Subscribe NowPopular Topics
- Machine Learning 30978
- Neural Networks, Computer 29696
- Algorithms 26813
- Deep Learning 26324
- Artificial Intelligence 24267
- Robotics 13307
- Image Processing, Computer-Assisted 9512
- Retrospective Studies 9097
- Magnetic Resonance Imaging 6173
- Reproducibility of Results 5589
- Tomography, X-Ray Computed 4765
- Support Vector Machine 4678
- Computational Biology 4229
- Brain 4045
- Computer Simulation 3877
Recent Journals
- Scientific reports 5865
- Sensors (Basel, Switzerland) 4794
- PloS one 4011
- Neural networks : the official journal of the International Neural Network Society 2928
- Computational intelligence and neuroscience 1931
- Computers in biology and medicine 1839
- Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 1686
- Studies in health technology and informatics 1278
- IEEE journal of biomedical and health informatics 1129
- Journal of chemical information and modeling 994
- Nature communications 938
- Computer methods and programs in biomedicine 883
- Bioinformatics (Oxford, England) 861
- Briefings in bioinformatics 850
- IEEE transactions on neural networks and learning systems 823