AIMC Topic: Gene Expression Profiling
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Exploring the mechanism of metabolic cell death-related genes AKR1C2 and MAP1LC3A as biomarkers in Parkinson's disease.
Scientific reports
Jul 15, 2025
There is a strong relationship between metabolic cell death (MCD) and neurodegenerative diseases. However, the involvement of metabolic cell death (MCD)-related genes (MCDRGs) in Parkinson's disease (PD) pathogenesis remains poorly analyzed. Integrat...
Exploring novel molecular mechanisms underlying recurrent pregnancy loss in decidual tissues.
Scientific reports
Jul 15, 2025
Recurrent pregnancy loss (RPL), which affects approximately 2.5% of reproductive-aged women, remains idiopathic in more than 50% of cases, necessitating mechanistic insights and biomarkers. Three RPL decidual tissue transcriptomic datasets (GSE113790...
Identification and experimental validation of BMX as a crucial PANoptosis‑related gene for immune response in Spinal Cord Injury.
PloS one
Jul 15, 2025
Spinal cord injury (SCI) is a debilitating neurological condition that severely impacts motor, sensory, and autonomic functions, leading to significant challenges in patient quality of life and imposing substantial economic burdens on society. PANopt...
Identification and analysis of pyroptosis-related key genes in heart failure.
Journal of cardiothoracic surgery
Jul 14, 2025
BACKGROUND: Pyroptosis plays a pivotal role in the pathogenesis of Heart Failure (HF). However, the current understanding of how pyroptosis-related genes (PRGs) influence HF is scarce. This study aimed to explore the link between PRGs and HF based on...
Integrated bioinformatics and machine learning reveal key genes and immune mechanisms associated with uremia.
Scientific reports
Jul 14, 2025
Uremia is a serious complication of end-stage chronic kidney disease, closely associated with immune imbalance and chronic inflammation. However, its molecular mechanisms remain largely unclear. In this study, we analyzed transcriptomic data from the...
A comprehensive analysis of transcription factors identified TCF3 as a prognostic target for glioma.
Scientific reports
Jul 13, 2025
Transcription factors (TFs) are pivotal in tumor initiation and progression, regulating downstream gene expression and modulating cellular processes. In this study, we conducted a comprehensive analysis of TF gene sets to define the molecular subtype...
Transcription Factors
Glioma
Basic Helix-Loop-Helix Transcription Factors
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Mutation
Protein Interaction Maps
Gene Regulatory Networks
Gene Expression Regulation, Neoplastic
Biomarkers, Tumor
Brain Neoplasms
Gene Expression Profiling
Humans
Prognosis
Identification and validation of epithelial‑mesenchymal transition‑related genes for diabetic nephropathy by WGCNA and machine learning.
Molecular medicine reports
Jul 11, 2025
Diabetic nephropathy (DN) is the main cause of end‑stage renal disease, with epithelial‑mesenchymal transition (EMT) serving a key role in its initiation and progression. Nevertheless, the precise mechanisms involved remain unidentified. The present ...
Diagnostic immune-related markers for diabetic kidney disease: a bioinformatics and machine learning approach.
Renal failure
Jul 10, 2025
OBJECTIVE: Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease, with chronic inflammation driving its progression. This study aimed to identify immune-related diagnostic biomarkers for DKD and explore their association with imm...
Single-cell spatial transcriptomics reveals immunotherapy-driven bone marrow niche remodeling in AML.
Science advances
Jul 9, 2025
Given the graft-versus-leukemia effect observed with allogeneic hematopoietic stem cell transplantation in refractory or relapsed acute myeloid leukemia (AML), immunotherapies have been explored in nontransplant settings. We applied a multiomic appro...
Anoikis-related biomarkers PARP1 and SDCBP as diagnostic and therapeutic targets for asthma.
Scientific reports
Jul 9, 2025
This study aims to explore the association between anoikis-related genes (ARGs) and asthma. The dataset GSE143303 for asthma were sourced from the GEO database, while ARGs were retrieved from the Harmonizome web portal and the GeneCards database. Dif...
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