Humans
Showing 69611 to 69620 of 95995 articles
Regional arterial stiffness in central and peripheral arteries is differentially related to endothelial dysfunction assessed by brachial flow-mediated dilation in metabolic syndrome.
Diabetes & vascular disease research
Dec 28, 2017
The interrelationship between endothelial function and arterial stiffness may be different for central and peripheral arteries due to their structural and functional differences. The study aims to assess the interrelationship between central and peri...
(1)
Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis.
European journal of medicinal chemistry
Dec 28, 2017
Bruton's tyrosine kinase (Btk) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) and Fcγ receptor (FcR) signaling pathways, which makes it a uniquely attractive target for the treatment of autoimmune diseases, such as rheum...
Haplorhini
Pyrroles
Rats, Sprague-Dawley
Microsomes, Liver
Dose-Response Relationship, Drug
Mice
Protein Kinase Inhibitors
Humans
Structure-Activity Relationship
Cell Line
Pyrimidines
Arthritis, Rheumatoid
Animals
Models, Molecular
Protein-Tyrosine Kinases
Rats
Agammaglobulinaemia Tyrosine Kinase
Drug Design
Molecular Structure
Cell Proliferation
Dogs
Physical Compatibility of Meropenem and Vaborbactam With Select Intravenous Drugs During Simulated Y-site Administration.
Clinical therapeutics
Dec 28, 2017
PURPOSE: Meropenem/vaborbactam is a novel intravenous antibiotic combining the carbapenem, meropenem, with a novel β-lactamase inhibitor, vaborbactam. Meropenem/vaborbactam is administered as a 3-hour infusion given every 8 hours, thereby potentially...
(1)
Magnetically Coated Bioabsorbable Stents for Renormalization of Arterial Vessel Walls after Stent Implantation.
Nano letters
Dec 28, 2017
The insertion of a stent in diseased arteries is a common endovascular procedure that can be compromised by the development of short- and long-term inflammatory responses leading to restenosis and thrombosis, respectively. While treatment with drugs,...
Deep Convolutional Neural Networks Enable Discrimination of Heterogeneous Digital Pathology Images.
EBioMedicine
Dec 28, 2017
Pathological evaluation of tumor tissue is pivotal for diagnosis in cancer patients and automated image analysis approaches have great potential to increase precision of diagnosis and help reduce human error. In this study, we utilize several computa...
Laparoscopic Approach for Shull Repair of Pelvic Floor Defects.
Journal of minimally invasive gynecology
Dec 28, 2017
STUDY OBJECTIVE: To prove the feasibility of the Shull technique by a laparoscopic approach in a patient affected by pelvic organ prolapse (POP) with apical loss of support.
The effect of fasting status on lipids, lipoproteins, and inflammatory biomarkers assessed after hospitalization for an acute coronary syndrome: Insights from PROVE IT-TIMI 22.
Clinical cardiology
Dec 28, 2017
BACKGROUND: For decades, fasting for 8 to 12 hours has been recommended for measurement of lipid profiles. The effect of fasting on low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) has been described in healthy cohorts and those wit...
A novel method for the rapid detection of post-translationally modified visinin-like protein 1 in rat models of brain injury.
Brain injury
Dec 28, 2017
BACKGROUND: Although elevated serum levels of visinin-like protein 1 (VILIP-1), a neuron-specific calcium sensor protein, are associated with ischaemic stroke, only a single study has evaluated VILIP-1 as a biomarker of traumatic brain injury (TBI). ...
Regional physiology of ARDS.
Critical care (London, England)
Dec 28, 2017
The acute respiratory distress (ARDS) lung is usually characterized by a high degree of inhomogeneity. Indeed, the same lung may show a wide spectrum of aeration alterations, ranging from completely gasless regions, up to hyperinflated areas. This in...
Stable solution to l -based robust inductive matrix completion and its application in linking long noncoding RNAs to human diseases.
BMC medical genomics
Dec 28, 2017
BACKGROUNDS: A large number of long intergenic non-coding RNAs (lincRNAs) are linked to a broad spectrum of human diseases. The disease association with many other lincRNAs still remain as puzzle. Validation of such links between the two entities thr...
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