AIMC Topic: Inflammation

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Identification of inflammation-related biomarkers and therapeutic targets for neurogenic bladder fibrosis via multi-omics analysis.

Computers in biology and medicine
Inflammatory responses play a crucial role in the progression of pediatric neurogenic bladder (NB)-associated fibrosis; however, their specific contributions remain poorly understood. This study aimed to identify inflammation-related biomarkers for d...

Interpretable machine learning models based on body composition and inflammatory nutritional index (BCINI) to predict early postoperative recurrence of colorectal cancer: Multi-center study.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: Colorectal cancer (CRC) ranks among the most prevalent cancers worldwide, with early postoperative recurrence remaining a major cause of mortality. Body composition and inflammatory-nutritional indices (BCINI) have demonstra...

Tribulus terrestris L. Extract Alleviates Atherosclerosis by Suppressing TNF-α-Mediated Macrophage Inflammation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Atherosclerosis (AS) is a major contributor to cardiovascular disease. In traditional Chinese medicine, Tribulus terrestris L., or Baijili (BJL), has shown therapeutic effects on inflammation and cardiovascular issues. Our prior research indicated th...

Developing an Explainable Prognostic Model for Acute Ischemic Stroke: Combining Clinical and Inflammatory Biomarkers With Machine Learning.

Brain and behavior
BACKGROUND: Predicting the prognosis of patients with acute cerebral infarction (ACI) is crucial for clinical decision-making and personalized treatment. However, existing models often lack the comprehensive integration of clinical and biological ind...

Blood immuno-metabolic biomarker signatures of depression and affective symptoms in young adults.

Brain, behavior, and immunity
BACKGROUND: Depression is associated with alterations in immuno-metabolic biomarkers, but it remains unclear whether these alterations are limited to specific markers, and whether there are subtypes of depression and depressive symptoms which are ass...

Automatic transformer-based grading of multiple retinal inflammatory signs in uveitis on fluorescein angiography.

Computers in biology and medicine
BACKGROUND: Grading fluorescein angiography (FA) for uveitis is complex, often leading to the oversight of retinal inflammation in clinical studies. This study aims to develop an automated method for grading retinal inflammation.

Mesenchymal stem cell transplantation ameliorates inflammation in spinal cord injury by inhibiting lactylation-related genes.

Cytokine
BACKGROUND: The immune microenvironment significantly influences neural regeneration in spinal cord injury (SCI). Lactate activates central nervous system (CNS) glial cells, prompting the secretion of proinflammatory cytokines and triggering an infla...

Systemic coagulation-inflammation index in the prediction of ISR in patients undergoing drug-eluting stents implant: A retrospective study based on multiple machine learning methods.

International journal of cardiology
BACKGROUND: The Systemic Coagulation-Inflammation index (SCI) is an innovative hematological metric that accurately reflects both coagulopathic and inflammatory dynamics. In this paper, the objective of this paper is to explain the prognostic impact ...

Cost-effectiveness of a novel AI technology to quantify coronary inflammation and cardiovascular risk in patients undergoing routine coronary computed tomography angiography.

European heart journal. Quality of care & clinical outcomes
AIMS: Coronary computed tomography angiography (CCTA) is a first-line investigation for chest pain in patients with suspected obstructive coronary artery disease (CAD). However, many acute cardiac events occur in the absence of obstructive CAD. We as...

Identification and validation of inflammatory response genes linking chronic kidney disease with coronary artery disease based on bioinformatics and machine learning.

Scientific reports
Coronary artery disease (CAD) commonly occurs and elevates the risk of cardiovascular events and mortality in chronic kidney disease (CKD) patients. The underlying pathogenesis of CKD-related CAD is believed to be closely linked to inflammatory respo...