AIMC Topic: Interleukin-1beta
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A morphology and secretome map of pyroptosis.
Molecular biology of the cell
Apr 9, 2025
Pyroptosis represents one type of programmed cell death. It is a form of inflammatory cell death that is canonically defined by caspase-1 cleavage and Gasdermin-mediated membrane pore formation. Caspase-1 initiates the inflammatory response (through ...
Multimodal feature fusion machine learning for predicting chronic injury induced by engineered nanomaterials.
Nature communications
Mar 20, 2025
Concerns regarding chronic injuries (e.g., fibrosis and carcinogenesis) induced by nanoparticles raised public health concerns and need to be rapidly assessed in hazard identification. Although in silico analysis is commonly used for risk assessment ...
Identification of biomarkers associated with phagocytosis regulatory factors in coronary artery disease using machine learning and network analysis.
Mammalian genome : official journal of the International Mammalian Genome Society
Feb 14, 2025
BACKGROUND: Coronary artery disease (CAD) is the leading cause of death worldwide, and aberrant phagocytosis may be involved in its development. Understanding this aspect may provide new avenues for prompt CAD diagnosis.
Receptors, IgG
Toll-Like Receptor 2
Syk Kinase
MicroRNAs
Interleukin-1beta
Coronary Artery Disease
Phagocytosis
Machine Learning
Biomarkers
Gene Expression Profiling
Protein Interaction Maps
Computational Biology
Gene Regulatory Networks
Humans
Transcription Factors
Polymorphism, Single Nucleotide
Databases, Genetic
Effects of aqueous and ethanolic extracts of Chinese propolis on dental pulp stem cell viability, migration and cytokine expression.
PeerJ
Dec 18, 2024
BACKGROUND: Propolis is a natural substance produced by honeybees that has various biological properties including, anti-inflammatory, antioxidant and antimicrobial properties. Although previous studies have evaluated the antimicrobial effects of pro...
Small molecule inhibitors of IL-1R1/IL-1β interaction identified via transfer machine learning QSAR modelling.
International journal of biological macromolecules
Nov 7, 2024
The human interleukin-1 receptor I (IL-1R1) is a cytokine receptor recognized by interleukin 1β (IL-1β), among other cytokines. Over activation of IL-1R1 has been implicated in various inflammatory conditions. This research aims to identify small-mol...
Exploring liquid-liquid phase separation-related diagnostic biomarkers in osteoarthritis based on machine learning algorithms and experiment.
Immunobiology
Jun 9, 2024
BACKGROUND: Osteoarthritis (OA) is a prevalent joint disorder characterized by cartilage degeneration and joint inflammation. Liquid-liquid phase separation (LLPS), a biophysical process involved in cellular organization, has recently gained attentio...
CKLF and IL1B transcript levels at diagnosis are predictive of relapse in children with pre-B-cell acute lymphoblastic leukaemia.
British journal of haematology
Feb 23, 2021
Disease relapse is the greatest cause of treatment failure in paediatric B-cell acute lymphoblastic leukaemia (B-ALL). Current risk stratifications fail to capture all patients at risk of relapse. Herein, we used a machine-learning approach to identi...
Chemokines
Transcriptome
Recurrence
Adolescent
Female
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Child, Preschool
Humans
Male
MARVEL Domain-Containing Proteins
Acute Disease
Child
Risk Assessment
Machine Learning
Predictive Value of Tests
Survival Analysis
Infant
Interleukin-1beta
Treatment Failure
Decreased gremlin 1 expression in women with BMI ≥35 kg/m is mediated by interleukin 10 and interleukin 1β in the follicular fluid.
F&S science
Jun 29, 2020
OBJECTIVE: To determine how body mass index (BMI) affects the follicular fluid cytokine milieu and investigate how this inflammatory environment impacts cumulus signaling.
The Effect of the Prethanol Extract of Trifolium pratense Leaves on Interleukin-1β-Induced Cartilage Matrix Degradation in Primary Rat Chondrocytes.
Cells, tissues, organs
Jan 31, 2019
BACKGROUND: Osteoarthritis (OA) is a degenerative joint disease, characterized by cartilage degradation and inflammation. The proinflammatory cytokine, interleukin (IL)-1β, plays a crucial role in the pathogenesis of OA by inducing the release of oth...
Evaluation of Effect of Glucosamine-Chondroitin Sulfate, Tramadol, and Sodium Hyaluronic Acid on Expression of Cytokine Levels in Internal Derangement of Temporomandibular Joint.
The journal of contemporary dental practice
Dec 1, 2018
AIM: Evaluation of the effect of glucosamine-chondroitin combination, tramadol, and sodium hyaluronic acid in temporomandibular joint (TMJ) disorders and its impact on the expression of various cytokines such as IL-6, IL-1β, TNF-α, and PGE2.
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