AIMC Topic: Leukocytes

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The viral expression and immune status in human cancers and insights into novel biomarkers of immunotherapy.

BMC cancer Nov 5, 2021
BACKGROUND: Viral infections are prevalent in human cancers and they have great diagnostic and theranostic values in clinical practice. Recently, their potential of shaping the tumor immune microenvironment (TIME) has been related to the immunotherap...
Support Vector Machine DNA, Viral Epstein-Barr Virus Infections Herpesvirus 4, Human Immunotherapy Papillomavirus Infections Squamous Cell Carcinoma of Head and Neck Head and Neck Neoplasms Genome, Viral Tumor Virus Infections Kaplan-Meier Estimate Papillomaviridae Oncogenic Viruses Mutation Leukocytes Genetic Variation High-Throughput Nucleotide Sequencing Humans Machine Learning Stomach Neoplasms Tumor Microenvironment Biomarkers, Tumor Neoplasms Transcriptome RNA-Seq
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New segmentation and feature extraction algorithm for classification of white blood cells in peripheral smear images.

Scientific reports Sep 30, 2021
This article addresses a new method for the classification of white blood cells (WBCs) using image processing techniques and machine learning methods. The proposed method consists of three steps: detecting the nucleus and cytoplasm, extracting featur...
Leukocyte Count Humans Machine Learning Image Processing, Computer-Assisted Leukocytes
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Swarm Learning for decentralized and confidential clinical machine learning.

Nature May 26, 2021
Fast and reliable detection of patients with severe and heterogeneous illnesses is a major goal of precision medicine. Patients with leukaemia can be identified using machine learning on the basis of their blood transcriptomes. However, there is an i...
Humans Machine Learning Software Male Disease Outbreaks Leukocytes Confidentiality Lung Diseases COVID-19 Precision Medicine Clinical Decision-Making Female Tuberculosis Datasets as Topic Leukemia Blockchain
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Tens of images can suffice to train neural networks for malignant leukocyte detection.

Scientific reports Apr 12, 2021
Convolutional neural networks (CNNs) excel as powerful tools for biomedical image classification. It is commonly assumed that training CNNs requires large amounts of annotated data. This is a bottleneck in many medical applications where annotation r...
Databases as Topic Neural Networks, Computer Image Processing, Computer-Assisted Leukocytes Lymphocytes Humans
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Artificial intelligence and leukocyte epigenomics: Evaluation and prediction of late-onset Alzheimer's disease.

PloS one Mar 31, 2021
We evaluated the utility of leucocyte epigenomic-biomarkers for Alzheimer's Disease (AD) detection and elucidates its molecular pathogeneses. Genome-wide DNA methylation analysis was performed using the Infinium MethylationEPIC BeadChip array in 24 l...
Alzheimer Disease Humans CpG Islands Biomarkers Late Onset Disorders Prognosis Epigenomics Signal Transduction DNA Methylation Leukocytes Male Female Case-Control Studies Deep Learning Aged Genome-Wide Association Study Aged, 80 and over Epigenesis, Genetic Sensitivity and Specificity
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Deep learning-based enhancement of epigenomics data with AtacWorks.

Nature communications Mar 8, 2021
ATAC-seq is a widely-applied assay used to measure genome-wide chromatin accessibility; however, its ability to detect active regulatory regions can depend on the depth of sequencing coverage and the signal-to-noise ratio. Here we introduce AtacWorks...
Deep Learning Mice Epigenomics Leukocytes Regulatory Sequences, Nucleic Acid Chromatin Chromatin Immunoprecipitation Sequencing Humans Brain Animals
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Machine Learning Identifies Complicated Sepsis Course and Subsequent Mortality Based on 20 Genes in Peripheral Blood Immune Cells at 24 H Post-ICU Admission.

Frontiers in immunology Feb 22, 2021
A complicated clinical course for critically ill patients admitted to the intensive care unit (ICU) usually includes multiorgan dysfunction and subsequent death. Owing to the heterogeneity, complexity, and unpredictability of the disease progression,...
Machine Learning Biomarkers Intensive Care Units Reproducibility of Results Gene Expression Profiling Transcriptome Sepsis Time Factors Leukocytes Humans Hospital Mortality Critical Care ROC Curve Disease Susceptibility Computational Biology Chromosome Mapping Databases, Genetic
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Improving blood cells classification in peripheral blood smears using enhanced incremental training.

Computers in biology and medicine Feb 18, 2021
Peripheral Blood Smear (PBS) analysis is a vital routine test carried out by medical specialists to assess some health aspects of individuals. The automation of blood analysis has attracted the attention of researchers in recent years, as it will not...
Humans Neural Networks, Computer Deep Learning Image Processing, Computer-Assisted Leukocytes Blood Cells
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Antibody Supervised Training of a Deep Learning Based Algorithm for Leukocyte Segmentation in Papillary Thyroid Carcinoma.

IEEE journal of biomedical and health informatics Feb 5, 2021
The quantity of leukocytes in papillary thyroid carcinoma (PTC) potentially have prognostic and treatment predictive value. Here, we propose a novel method for training a convolutional neural network (CNN) algorithm for segmenting leukocytes in PTCs....
Thyroid Cancer, Papillary Deep Learning Thyroid Neoplasms Image Processing, Computer-Assisted Humans Leukocytes Algorithms Retrospective Studies
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Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis.

Proceedings of the National Academy of Sciences of the United States of America Dec 14, 2020
Contact dermatitis tremendously impacts the quality of life of suffering patients. Currently, diagnostic regimes rely on allergy testing, exposure specification, and follow-up visits; however, distinguishing the clinical phenotype of irritant and all...
Dermatitis, Irritant Severity of Illness Index Female Transcriptome Diagnosis, Differential Gene Expression Regulation Reproducibility of Results Gene Regulatory Networks Skin Irritants Databases, Genetic Leukocytes Adult Humans Dermatitis, Allergic Contact Allergens Male Machine Learning Patch Tests Algorithms Biomarkers
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