AIMC Topic: Limit of Detection

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Highly Sensitive and Interference-Free Detection of Multiple Drug Molecules in Serum Using Dual-Modified SERS Substrates Combined with AI Algorithm Analysis.

Analytical chemistry
Surface-enhanced Raman spectroscopy (SERS) technology has shown broad potential in drug concentration detection, but its application in blood drug monitoring faces significant challenges. The primary difficulty lies in overcoming the interference cau...

Deep Learning-Assisted Fluorescence Single-Particle Detection of Fumonisin B Powered by Entropy-Driven Catalysis and Argonaute.

Analytical chemistry
Timely and accurate detection of trace mycotoxins in agricultural products and food is significant for ensuring food safety and public health. Herein, a deep learning-assisted and entropy-driven catalysis (EDC)-Argonaute powered fluorescence single-p...

Deep-Learning-Assisted Digital Fluorescence Immunoassay on Magnetic Beads for Ultrasensitive Determination of Protein Biomarkers.

Analytical chemistry
Digital fluorescence immunoassay (DFI) based on random dispersion magnetic beads (MBs) is one of the powerful methods for ultrasensitive determination of protein biomarkers. However, in the DFI, improving the limit of detection (LOD) is challenging s...

Quantification of L-lactic acid in human plasma samples using Ni-based electrodes and machine learning approach.

Talanta
This work presents a robust strategy for quantifying overlapping electrochemical signatures originating from complex mixtures and real human plasma samples using nickel-based electrochemical sensors and machine learning (ML). This strategy enables th...

Bioinspired Iron Porphyrin Covalent Organic Frameworks-Based Nanozymes Sensor Array: Machine Learning-Assisted Identification and Detection of Thiols.

ACS applied materials & interfaces
Given the crucial role of thiols in maintaining normal physiological functions, it is essential to establish a high-throughput and sensitive analytical method to identify and quantify various thiols accurately. Inspired by the iron porphyrin active c...

Graphene FET biochip on PCB reinforced by machine learning for ultrasensitive parallel detection of multiple antibiotics in water.

Biosensors & bioelectronics
Antibiotics like Ciprofloxacin (Cfx), tetracycline (Tet) and Tobramycin (Tob) are commonly used against a broad-spectrum of bacterial infection. Recent surge in their uptake through the presence of their residues in environmental water has been linke...

Machine learning-driven fluorescent sensor array using aqueous CsPbBr perovskite quantum dots for rapid detection and sterilization of foodborne pathogens.

Journal of hazardous materials
With the growing global concern over food safety, the rapid detection and disinfection of foodborne pathogens have become critical in public health. This study presents a novel machine learning-driven fluorescent sensor array utilizing aqueous CsPbBr...

Unsupervised Learning-Assisted Acoustic-Driven Nano-Lens Holography for the Ultrasensitive and Amplification-Free Detection of Viable Bacteria.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Bacterial infection is a crucial factor resulting in public health issues worldwide, often triggering epidemics and even fatalities. The accurate, rapid, and convenient detection of viable bacteria is an effective method for reducing infections and i...

Machine learning-assisted SERS sensor for fast and ultrasensitive analysis of multiplex hazardous dyes in natural products.

Journal of hazardous materials
The adulteration of natural products with multiple azo dyes has become a serious public health concern. Thus, on-site trace additive detection is demanded. Herein, we developed a gold-nanorod-based surface-enhanced Raman scattering (SERS) sensor to d...

Plasma treated bimetallic nanofibers as sensitive SERS platform and deep learning model for detection and classification of antibiotics.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Design of a sensitive, cost-effective SERS substrate is critical for probing analyte in trace concentration in real field environment. Present work reports the fabrication of an oxygen (O) plasma treated bimetallic nanofibers as a sensitive SERS plat...