The maintenance of physical activity over time is a challenge for public health. Predictors of different physical activity intensities have not been sufficiently analyzed. This study aimed to identify clusters of trajectories of physical activity int...
BACKGROUND: Cognitive impairment, indicative of Alzheimer disease and other forms of dementia, significantly deteriorates the quality of life of older adult populations and imposes considerable burdens on families and health care systems worldwide. T...
OBJECTIVES: This study aims to develop and validate an artificial intelligence (AI) - driven model to assist periodontal therapy decision-making and minimize tooth loss.
BACKGROUND: Understanding the complex interplay between life course exposures, such as adverse childhood experiences and environmental factors, and disease risk is essential for developing effective public health interventions. Traditional epidemiolo...
NPJ primary care respiratory medicine
Apr 23, 2025
Primary care consultations provide an opportunity for patients and clinicians to assess asthma attack risk. Using a data-driven risk prediction tool with routinely collected health records may be an efficient way to aid promotion of effective self-ma...
Biological age (BA) and frailty represent two distinct health measures that offer valuable insights into the aging process. Comparing and analyzing blood-based biomarkers from the machine learning (ML) predictors of BA and frailty helps deepen our un...
International journal of molecular sciences
Apr 18, 2025
Hepatocellular carcinoma (HCC) is a major complication of tyrosinemia type 1 (HT-1), an inborn error of metabolism affecting tyrosine catabolism. The risk of HCC is higher in late diagnoses despite treatment. Alpha-fetoprotein (AFP) is widely used to...
BACKGROUND: Aging has become a global trend, and depression, as an accompanying issue, poses a significant threat to the health of middle-aged and older adults. Existing studies primarily rely on statistical methods such as logistic regression for sm...
BACKGROUND: The American Heart Association recently introduced the concept of cardiovascular-kidney-metabolic (CKM) syndrome, highlighting the increasing importance of the complex interplay between metabolic, renal, and cardiovascular diseases (CVD)....
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Apr 13, 2025
It is unclear if lithium and quetiapine have neuroprotective effects, especially in early stages of bipolar and schizoaffective disorders. Here, an age-related multivariate brain structural measure (i.e., brain-PAD) at baseline and changes in respons...
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