AIMC Topic: Mice, Inbred BALB C

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Vocal Fold Augmentation with Beta Glucan Hydrogel Cross-Linked by γ Irradiation for Enhanced Duration of Effect: In Vivo Animal Study.

BioMed research international Dec 13, 2015
This study explored a novel strategy to restore the vocal gap by using cross-linked β-glucan hydrogel by γ-irradiation. An aqueous solution of 5 wt% β-glucan was prepared and cross-linked using (60)Co γ irradiation. Ten nude mice were injected with 0...
Mice Mice, Nude Mice, Inbred BALB C beta-Glucans Rabbits Materials Testing Hydrogels Gamma Rays Vocal Cord Paralysis Vocal Cords Animals
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The antiviral activity of arctigenin in traditional Chinese medicine on porcine circovirus type 2.

Research in veterinary science Oct 26, 2015
Arctigenin (ACT) is a phenylpropanoid dibenzylbutyrolactone lignan extracted from the traditional herb Arctium lappa L. (Compositae) with anti-viral and anti-inflammatory effects. Here, we investigated the antiviral activity of ACT found in tradition...
Lignans Arctium Circoviridae Infections Circovirus Animals Medicine, Chinese Traditional Swine Swine Diseases Female Antiviral Agents Mice, Inbred BALB C Mice Injections, Intraperitoneal Furans Random Allocation
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Automated measurement of mouse social behaviors using depth sensing, video tracking, and machine learning.

Proceedings of the National Academy of Sciences of the United States of America Sep 9, 2015
A lack of automated, quantitative, and accurate assessment of social behaviors in mammalian animal models has limited progress toward understanding mechanisms underlying social interactions and their disorders such as autism. Here we present a new in...
Observer Variation Pattern Recognition, Automated Models, Animal Behavior, Animal Image Processing, Computer-Assisted Social Behavior Mice Machine Learning Mice, Inbred BALB C Software Computers Mice, Inbred C57BL Algorithms Female Video Recording Reproducibility of Results Animals Male
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Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery.

PLoS neglected tropical diseases Jun 26, 2015
BACKGROUND: Chagas disease is a neglected tropical disease (NTD) caused by the eukaryotic parasite Trypanosoma cruzi. The current clinical and preclinical pipeline for T. cruzi is extremely sparse and lacks drug target diversity.
Metabolic Networks and Pathways Mice Humans Genome, Protozoan Computational Biology Machine Learning Bayes Theorem Chagas Disease Disease Models, Animal Female High-Throughput Screening Assays Mice, Inbred BALB C Trypanocidal Agents Animals Trypanosoma cruzi Cell Line Drug Discovery
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Broadly active intranasal influenza vaccine with a nanocomplex particulate adjuvant targeting mast cells and toll-like receptor 9.

Journal of controlled release : official journal of the Controlled Release Society Aug 10, 2025
Flumist is the only FDA-approved intranasal influenza vaccine. Although it has recently been approved for at-home use, it has significant limitations. These include reduced effectiveness in generating a protective immune response in patients with ext...
Humans Female Animals Influenza Vaccines Mice Oligodeoxyribonucleotides Orthomyxoviridae Infections Nanoparticles Hemagglutinin Glycoproteins, Influenza Virus Administration, Intranasal Mice, Inbred BALB C Toll-Like Receptor 9 Mast Cells Adjuvants, Immunologic
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Deep learning for in vivo near-infrared imaging.

Proceedings of the National Academy of Sciences of the United States of America Jan 5, 2021
Detecting fluorescence in the second near-infrared window (NIR-II) up to ∼1,700 nm has emerged as a novel in vivo imaging modality with high spatial and temporal resolution through millimeter tissue depths. Imaging in the NIR-IIb window (1,500-1,700 ...
Intravital Microscopy Animals Cetuximab Microscopy, Fluorescence Neoplasms Indoles Spectroscopy, Near-Infrared Indocyanine Green Deep Learning Molecular Imaging Humans Cell Line, Tumor Mice Signal-To-Noise Ratio Neural Networks, Computer Lymph Nodes Mice, Nude Mice, Inbred BALB C Fluorescent Dyes
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Anti-inflammatory and antibacterial activities of P. petiolosa (Christ) Ching ethyl acetate extract against S. aureus in mice.

Pakistan journal of pharmaceutical sciences Sep 1, 2020
P. petiolosa as a typical Chinese herbal medicine has been generally utilized as Chinese native medicine formulation for treatment of chronic bronchitis, bronchial asthma and pneumoconiosis. The objective of this study was to evaluate the anti-inflam...
Anti-Inflammatory Agents Membrane Proteins Acetates Staphylococcus aureus Solvents Anti-Bacterial Agents Disease Models, Animal Bacterial Load Tumor Necrosis Factor-alpha Mice, Inbred BALB C Heme Oxygenase-1 Inflammation Mediators Animals Nitric Oxide Synthase Type II Plant Leaves Lung Pneumonia, Staphylococcal Plant Extracts Polypodiaceae
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Machine Learning Uncovers Food- and Excipient-Drug Interactions.

Cell reports Mar 17, 2020
Inactive ingredients and generally recognized as safe compounds are regarded by the US Food and Drug Administration (FDA) as benign for human consumption within specified dose ranges, but a growing body of research has revealed that many inactive ing...
Humans Hep G2 Cells Mice, Inbred BALB C Pharmaceutical Preparations ATP Binding Cassette Transporter, Subfamily B, Member 1 Drug Interactions Machine Learning Female Animals Swine United States Abietanes Biological Assay Excipients United States Food and Drug Administration Retinyl Esters Food Diterpenes Glucuronosyltransferase
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A Deep Learning Approach to Antibiotic Discovery.

Cell Feb 20, 2020
Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting molecules with antibacterial activity. We performed pr...
Clostridioides difficile Small Molecule Libraries Cheminformatics Thiadiazoles Mice, Inbred BALB C Mice, Inbred C57BL Mycobacterium tuberculosis Acinetobacter baumannii Databases, Chemical Machine Learning Anti-Bacterial Agents Animals Drug Discovery Mice
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Polysaccharides extracted from the roots of Bupleurum chinense DC modulates macrophage functions.

Chinese journal of natural medicines Dec 1, 2017
The present study aimed to investigate the effects of polysaccharides extracted from Bupleurum chinense DC (BCPs) on macrophage functions. In the in vivo experiment, 1 mL of 5% sodium thioglycollate was injected into the abdomen of the mice on Day 0 ...
Mice, Inbred BALB C Plant Roots Phagocytosis Immunologic Factors Polysaccharides Cytokines Macrophages Plants, Medicinal Animals Immunomodulation Mice Bupleurum Plant Extracts Chemotaxis Nitric Oxide
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