AIMC Topic: Mice, Inbred BALB C

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Vocal Fold Augmentation with Beta Glucan Hydrogel Cross-Linked by γ Irradiation for Enhanced Duration of Effect: In Vivo Animal Study.

BioMed research international Dec 13, 2015
This study explored a novel strategy to restore the vocal gap by using cross-linked β-glucan hydrogel by γ-irradiation. An aqueous solution of 5 wt% β-glucan was prepared and cross-linked using (60)Co γ irradiation. Ten nude mice were injected with 0...
Mice Mice, Nude Mice, Inbred BALB C beta-Glucans Rabbits Materials Testing Hydrogels Gamma Rays Vocal Cord Paralysis Animals Vocal Cords
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The antiviral activity of arctigenin in traditional Chinese medicine on porcine circovirus type 2.

Research in veterinary science Oct 26, 2015
Arctigenin (ACT) is a phenylpropanoid dibenzylbutyrolactone lignan extracted from the traditional herb Arctium lappa L. (Compositae) with anti-viral and anti-inflammatory effects. Here, we investigated the antiviral activity of ACT found in tradition...
Animals Lignans Swine Arctium Swine Diseases Circoviridae Infections Antiviral Agents Circovirus Mice Medicine, Chinese Traditional Female Mice, Inbred BALB C Injections, Intraperitoneal Furans Random Allocation
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Automated measurement of mouse social behaviors using depth sensing, video tracking, and machine learning.

Proceedings of the National Academy of Sciences of the United States of America Sep 9, 2015
A lack of automated, quantitative, and accurate assessment of social behaviors in mammalian animal models has limited progress toward understanding mechanisms underlying social interactions and their disorders such as autism. Here we present a new in...
Machine Learning Software Algorithms Observer Variation Pattern Recognition, Automated Models, Animal Behavior, Animal Social Behavior Image Processing, Computer-Assisted Mice Mice, Inbred BALB C Mice, Inbred C57BL Video Recording Computers Female Reproducibility of Results Animals Male
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Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery.

PLoS neglected tropical diseases Jun 26, 2015
BACKGROUND: Chagas disease is a neglected tropical disease (NTD) caused by the eukaryotic parasite Trypanosoma cruzi. The current clinical and preclinical pipeline for T. cruzi is extremely sparse and lacks drug target diversity.
Metabolic Networks and Pathways Mice Chagas Disease Genome, Protozoan Computational Biology Trypanocidal Agents Bayes Theorem Humans Disease Models, Animal High-Throughput Screening Assays Mice, Inbred BALB C Machine Learning Trypanosoma cruzi Cell Line Female Animals Drug Discovery
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Broadly active intranasal influenza vaccine with a nanocomplex particulate adjuvant targeting mast cells and toll-like receptor 9.

Journal of controlled release : official journal of the Controlled Release Society Aug 10, 2025
Flumist is the only FDA-approved intranasal influenza vaccine. Although it has recently been approved for at-home use, it has significant limitations. These include reduced effectiveness in generating a protective immune response in patients with ext...
Humans Female Animals Influenza Vaccines Orthomyxoviridae Infections Administration, Intranasal Oligodeoxyribonucleotides Hemagglutinin Glycoproteins, Influenza Virus Toll-Like Receptor 9 Mice Nanoparticles Mice, Inbred BALB C Mast Cells Adjuvants, Immunologic
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Deep learning for in vivo near-infrared imaging.

Proceedings of the National Academy of Sciences of the United States of America Jan 5, 2021
Detecting fluorescence in the second near-infrared window (NIR-II) up to ∼1,700 nm has emerged as a novel in vivo imaging modality with high spatial and temporal resolution through millimeter tissue depths. Imaging in the NIR-IIb window (1,500-1,700 ...
Intravital Microscopy Cetuximab Animals Neoplasms Microscopy, Fluorescence Spectroscopy, Near-Infrared Indoles Deep Learning Indocyanine Green Cell Line, Tumor Molecular Imaging Signal-To-Noise Ratio Mice Lymph Nodes Mice, Nude Mice, Inbred BALB C Humans Fluorescent Dyes Neural Networks, Computer
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Anti-inflammatory and antibacterial activities of P. petiolosa (Christ) Ching ethyl acetate extract against S. aureus in mice.

Pakistan journal of pharmaceutical sciences Sep 1, 2020
P. petiolosa as a typical Chinese herbal medicine has been generally utilized as Chinese native medicine formulation for treatment of chronic bronchitis, bronchial asthma and pneumoconiosis. The objective of this study was to evaluate the anti-inflam...
Anti-Inflammatory Agents Inflammation Mediators Acetates Membrane Proteins Anti-Bacterial Agents Nitric Oxide Synthase Type II Solvents Staphylococcus aureus Bacterial Load Pneumonia, Staphylococcal Disease Models, Animal Tumor Necrosis Factor-alpha Heme Oxygenase-1 Polypodiaceae Animals Mice, Inbred BALB C Lung Plant Leaves Plant Extracts
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Machine Learning Uncovers Food- and Excipient-Drug Interactions.

Cell reports Mar 17, 2020
Inactive ingredients and generally recognized as safe compounds are regarded by the US Food and Drug Administration (FDA) as benign for human consumption within specified dose ranges, but a growing body of research has revealed that many inactive ing...
Humans Hep G2 Cells Mice, Inbred BALB C Pharmaceutical Preparations ATP Binding Cassette Transporter, Subfamily B, Member 1 Drug Interactions Machine Learning Female Animals Swine United States Abietanes Biological Assay Excipients United States Food and Drug Administration Retinyl Esters Food Diterpenes Glucuronosyltransferase
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A Deep Learning Approach to Antibiotic Discovery.

Cell Feb 20, 2020
Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting molecules with antibacterial activity. We performed pr...
Clostridioides difficile Small Molecule Libraries Cheminformatics Thiadiazoles Mice, Inbred BALB C Mice, Inbred C57BL Mycobacterium tuberculosis Acinetobacter baumannii Databases, Chemical Machine Learning Anti-Bacterial Agents Animals Drug Discovery Mice
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Polysaccharides extracted from the roots of Bupleurum chinense DC modulates macrophage functions.

Chinese journal of natural medicines Dec 1, 2017
The present study aimed to investigate the effects of polysaccharides extracted from Bupleurum chinense DC (BCPs) on macrophage functions. In the in vivo experiment, 1 mL of 5% sodium thioglycollate was injected into the abdomen of the mice on Day 0 ...
Mice, Inbred BALB C Plant Roots Phagocytosis Immunologic Factors Polysaccharides Macrophages Cytokines Animals Mice Plants, Medicinal Plant Extracts Immunomodulation Nitric Oxide Bupleurum Chemotaxis
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