AIMC Topic: Mice, Knockout
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Cold receptor TRPM8 as a target for migraine-associated pain and affective comorbidities.
The journal of headache and pain
Jun 23, 2025
BACKGROUND: Genetic variations in the Trpm8 gene that encodes the cold receptor TRPM8 have been linked to protection against polygenic migraine, a disabling condition primarily affecting women. Noteworthy, TRPM8 has been recently found in brain areas...
Gasdermin D drives the systemic storm and mortality after trauma with hemorrhage to a greater degree in biological females than males.
Science translational medicine
May 28, 2025
Severe injury accompanied by hemorrhagic shock triggers an early release of cell constituents into the circulation, referred to as the systemic storm. The systemic storm drives the systemic inflammatory response and is associated with increased morta...
Machine learning-based prediction reveals kinase MAP4K4 regulates neutrophil differentiation through phosphorylating apoptosis-related proteins.
PLoS computational biology
Mar 17, 2025
Neutrophils, an essential innate immune cell type with a short lifespan, rely on continuous replenishment from bone marrow (BM) precursors. Although it is established that neutrophils are derived from the granulocyte-macrophage progenitor (GMP), the ...
Computational staining of CD3/CD20 positive lymphocytes in human tissues with experimental confirmation in a genetically engineered mouse model.
Frontiers in immunology
Oct 28, 2024
INTRODUCTION: Immune dysregulation plays a major role in cancer progression. The quantification of lymphocytic spatial inflammation may enable spatial system biology, improve understanding of therapeutic resistance, and contribute to prognostic imagi...
Salivary detection of Chikungunya virus infection using a portable and sustainable biophotonic platform coupled with artificial intelligence algorithms.
Scientific reports
Sep 16, 2024
The current detection method for Chikungunya Virus (CHIKV) involves an invasive and costly molecular biology procedure as the gold standard diagnostic method. Consequently, the search for a non-invasive, more cost-effective, reagent-free, and sustain...
Non-Invasive Detection of Early-Stage Fatty Liver Disease via an On-Skin Impedance Sensor and Attention-Based Deep Learning.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jun 17, 2024
Early-stage nonalcoholic fatty liver disease (NAFLD) is a silent condition, with most cases going undiagnosed, potentially progressing to liver cirrhosis and cancer. A non-invasive and cost-effective detection method for early-stage NAFLD detection i...
MASP-2 deficiency does not prevent the progression of diabetic kidney disease in a mouse model of type 1 diabetes.
Scandinavian journal of immunology
Dec 25, 2023
Mannan-binding lectin (MBL) initiates the lectin pathway of complement and has been linked to albuminuria and mortality in diabetes. We hypothesize that MBL-associated serine protease 2 (MASP-2) deficiency will protect against diabetes-induced kidney...
Structural, functional and molecular pathogenesis of pelvic organ prolapse in patient and deficient mice.
Aging
Dec 19, 2021
Pelvic organ prolapse is a worldwide health problem to elderly women. Understanding its pathogenesis and an ideal animal model are crucial to developing promising treatments. The present study aimed to investigate new clinical significance and detail...
Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease.
Nature communications
Jul 12, 2021
Modeling human diseases as networks simplify complex multi-cellular processes, helps understand patterns in noisy data that humans cannot find, and thereby improves precision in prediction. Using Inflammatory Bowel Disease (IBD) as an example, here w...
Likelihood Functions
Dextran Sulfate
Colitis
Organoids
Artificial Intelligence
AMP-Activated Protein Kinases
Machine Learning
Multigene Family
Inflammatory Bowel Diseases
Gene Expression Regulation
Reproducibility of Results
Molecular Targeted Therapy
Disease Models, Animal
Humans
Animals
Mice, Inbred C57BL
Cohort Studies
Intestinal Mucosa
Mice
Mice, Knockout
Treatment Outcome
Enhanced Integrated Gradients: improving interpretability of deep learning models using splicing codes as a case study.
Genome biology
Jun 19, 2020
Despite the success and fast adaptation of deep learning models in biomedical domains, their lack of interpretability remains an issue. Here, we introduce Enhanced Integrated Gradients (EIG), a method to identify significant features associated with ...
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